Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and the ventral diencephalon)...
Peer reviewed: True / Inflammation and immune dysregulation have been linked to the pathogenesis and progression of Parkinson's disease (PD), and represent an attractive target for therapeutic intervention, given the potential for repurposing of existing anti-inflammatory and immunomodulatory agents. Despite the fact that initial studies of drugs ...
ObjectifLes données de santé, et en particulier d’imagerie, sont au cœur du système de santé comme des projets de recherche sur cohorte. Leur réutilisation secondaire bien que source d’innovation, est sujette à une règlementation spécifique. Avec le développement d’outils d’intelligence artificielle, et d’espaces spécifiques d’accès à ces données s...
Peer reviewed: True / In 2011, the UK medical research charity Cure Parkinson's set up the international Linked Clinical Trials (iLCT) committee to help expedite the clinical testing of potentially disease modifying therapies for Parkinson's disease (PD). The first committee meeting was held at the Van Andel Institute in Grand Rapids, Michigan in 2...
Peer reviewed: True / BACKGROUND: Exercise promotion interventions for people with Parkinson's disease (PD) are often offered on a face-to-face basis, follow a generic "one-size-fit-all" approach, and are not typically delivered at diagnosis. Considering PD's heterogenous nature, the existing evidence on the merits of exercise on symptom management...
Peer reviewed: True / Parkinson's disease (PD) is an increasingly prevalent neurological disorder, affecting more than 8.5 million individuals worldwide. α-Synucleinopathy in PD is considered to cause dopaminergic neuronal loss in the substantia nigra, resulting in characteristic motor dysfunction that is the target for current medical and surgical...
BACKGROUND: A simple prognostic model was previously developed to predict the probability of recently-diagnosed patients reaching negative outcomes (postural instability, dementia or death) in a 5-year period. OBJECTIVES: To validate this model in an independent cohort and establish utility at later time points. METHODS: Validation was performed us...
BACKGROUND AND OBJECTIVES: It is widely cited that dementia occurs in up to 80% of patients with Parkinson disease (PD), but studies reporting such high rates were published over two decades ago, had relatively small samples, and had other limitations. We aimed to determine long-term dementia risk in PD using data from two large, ongoing, prospecti...
Parkinsonova choroba (PD) je celosvětově druhým nejčastějším neurodegenerativním onemocněním. Především viditelné motorické příznaky jsou doprovázeny postupným úpadkem kognitivních funkcí, což dohromady přináší pacientům problémy, které jim mění život. I když je stále nevyléčitelná, je zásadní odhalit probíhající neurodegeneraci co nejdříve. Během ...
Estimates of the spectrum and frequency of pathogenic variants in Parkinson's disease (PD) in different populations are currently limited and biased. Furthermore, although therapeutic modification of several genetic targets has reached the clinical trial stage, a major obstacle in conducting these trials is that PD patients are largely unaware of t...
