Published in Nature Communications
Deriving functional pancreatic cell types from human stem cells may have important clinical applications. Building on previous work, here the authors generate stem cell-derived alpha cells via a polyhormonal intermediate, which have a gene expression pattern similar to human islet alpha cells and behave as such when transplanted into mice.
Published in World Journal of Clinical Cases
BACKGROUND Pancreatic arteriovenous malformation (AVM) is a rare disease with a number of different reported treatment methods, but there are as yet no established or definite treatments for the disease. CASE SUMMARY A 43-year-old man visited the hospital due to periumbilical pain. The patient underwent imaging study and laboratory testing for eval...
Published in BMC Gastroenterology
BackgroundOne of the most feared complications of endoscopic retrograde cholangiopancreatography (ERCP), with an incidence of 3.5 to 15%, is post ERCP pancreatitis (PEP). Given the role of statins in the reduction of systemic and pancreatic intraluminal inflammation, we hypothesized that the use of statins may lower the risk of PEP.MethodsA retrosp...
Published in Nature Communications
Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.
Published in BMC Surgery
BackgroundPapillary thyroid cancer (PTC) is the most common form of well-differentiated endocrine malignancy. Distant metastases of PTC are rare and usually occur in the bones, lungs, and thoracic lymph nodes despite the common locoregional metastases to the lymph nodes of the neck. The metastasis of PTC to the pancreas is extremely rare. Here, we ...
Published in Archivum Immunologiae et Therapiae Experimentalis
Interactions between the immune system and the pancreas are pivotal in understanding how and why β cells’ damage causes problems with pancreas functioning. Pancreatic islets are crucial in maintaining glucose homeostasis in organs, tissue and cells. Autoimmune aggression towards pancreatic islets, mainly β cells, leads to type 1 diabetes—one of the...
Published in Current Diabetes Reports
Purpose of ReviewFibrocalculous pancreatic diabetes (FCPD) is an uncommon form of diabetes occurring in underprivileged developing countries of the world. We attempt to review the latest evidence on epidemiology, secular trends, etiopathogenic mechanisms, and treatment modalities of FCPD with particular reference to studies from the past decade.Rec...
Published in Molecular Metabolism
• Distal gut Gcg expression is dispensable for GLP-1 response to olive oil and arginine. • GLP-1 response to GPR119 and MCR4 agonism requires distal gut Gcg expression. • The maximal GLP-1 response to lipopolysaccharide requires distal gut Gcg expression. • The distal gut is a substantial source of GLP-1 release in response to metformin.
Published in World Journal of Clinical Cases
BACKGROUND Pancreatic acinar cell carcinoma (PACC) is a rare type of malignant pancreatic cancer that represents approximately 1% of all pancreatic neoplasms. Due to its very low incidence, only a few retrospective studies are available. Although surgery is the first choice for treatment, most patients experience recurrence (mainly in the liver) an...
We studied the effects of pancreatic enzyme replacement therapy (PERT) on body weight, nutritional status, and quality of life (QoL) in patients with pancreatic exocrine insufficiency after pancreatoduodenectomy. We performed a randomized, double-blind trial of 304 patients who underwent pancreatoduodenectomy at 7 tertiary referral hospitals in Sou...
