Surface compositions play a predominant role in the efficiency and lifetime of membranes and catalysts. The surface composition can change during operation due to segregation, thus controlling and predicting the surface composition is essential. Computational modelling can aid in predicting alloy stability, along with designing surface alloys and n...
Pure (TiO2) and 0.1 nominal atomic percent of palladium-modified TiO2 (Pd-TiO2) films were synthesized via a sol-gel method and compared through their physicochemical properties and photocatalytic activity in the degradation of an emerging contaminant, 17-α-ethinylestradiol (EE2). The activity of the films was studied using a continuous flow, plana...
Published in Journal of inorganic biochemistry
A significant fraction of patients are affected by persistent fear and anxiety. Currently, there are several anxiolytic drug options, however their clinical outcomes do not fully manage the symptoms. Here, we evaluated the effects of a bromazepam‑palladium derivative [2-{(7-bromo-2-oxo-1,3-dihydro-2H-1,4-benzodiazepin-5-il)pyridinyl-κ2-N,N}chloropa...
Published in Angewandte Chemie (International ed. in English)
N-N Atropisomers are a common motif in natural products and represent a significant dimension for exploration in modern pharmaceutical and medicinal chemistry. However, the catalytic atroposelective synthesis of such molecules remains challenging, hampering meaningful development. In particular, an enantioselective synthesis of N-N bisindole atropi...
peer reviewed / The alkylation of caffeine with methyl iodide afforded 1,3,7,9-tetramethylxanthinium iodide, which was further reacted with PdCl2, KI, and K2CO3 in neat pyridine to afford the [PdI2(NHC)(Py)] complex 1 in two steps and 73% overall yield. An intermediate anion exchange afforded the corresponding dichlorido complex 2 in 70% overall yi...
Published in Angewandte Chemie (International ed. in English)
Chiral perhydroindoles are found in a number of natural products and biologically active compounds. Therefore, the development of new asymmetric methodology for rapid access to this core is of high importance. Herein, we reported a highly regio- and diastereo-selective palladium/PC-Phos-catalyzed asymmetric Heck/Tsuji-Trost reactions of readily ava...
Published in Angewandte Chemie (International ed. in English)
The transition-metal-catalyzed carbonylation reaction is a useful approach for ketone synthesis. However, it is often problematic to use exogenous carbonyl reagents, such as gaseous carbon monoxide. In this manuscript, we report a novel palladium-catalyzed coupling reaction of gem-difluoroalkenes and aryl boronic acids that yields bioactive indane-...
Published in Angewandte Chemie (International ed. in English)
A novel and expedient cascade strategy has been demonstrated for the synthesis of fused benzo-aza-oxa-[5-6-5] tetracycles in high yields and diastereoselectivities (up to 20 : 1 dr). The strategy was fulfilled through palladium-catalyzed oxidative convergent assembly of functionally divergent anilines and 3-butenoic acid with five chemical bonds co...
Published in Angewandte Chemie (International ed. in English)
Catalytic systems for direct C-H activation of arenes commonly show preference for electronically activated and sterically exposed C-H sites. Here we show that a range of functionally rich and pharmaceutically relevant arene classes can undergo site-selective C-H arylation ortho to small alkyl substituents, preferably endocyclic methylene groups. T...
Published in Angewandte Chemie (International ed. in English)
Self-assembly makes metallo-interlocked architectures attractive targets, but being in equilibrium with smaller species means that they can suffer from dilution effects. We show that a junctioned system gives rise to a [Pd4 (L)2 ]8+ trefoil entangled tetrahedron irrespective of concentration. Heating the sample reversibly shifts the equilibrium fro...
