Published in Scientific Reports
Oxytocin possesses several physiological and social functions, among which an important analgesic effect. For this purpose, oxytocin binds mainly to its unique receptor, both in the central nervous system and in the peripheral nociceptive terminal axon in the skin. However, despite its interesting analgesic properties and its current use in clinics...
Published in Acta neurologica Belgica
The pain modulatory role of the paragigantocellularis lateralis nucleus (LPGi) and the 17β-estradiol has thoroughly been probed. This study investigates the contribution of ionotropic glutamate receptors in pain modulatory effect of intra-LPGi injection of 17β-estradiol. For this purpose, the LPGi nucleus cannulation was performed and drugs were in...
Published in Orphanet Journal of Rare Diseases
BackgroundSymptomatic spinal stenosis (SSS) is a well-known medical complication in achondroplasia. The reported prevalence of SSS is 10 to 30%, an estimate based on small studies or selected populations. No population-based studies exist currently. Furthermore, the relationship between SSS and physical functioning has not been investigated in deta...
Published in BMC Veterinary Research
BackgroundBuprenorphine is used for canine postoperative pain management. This study aimed to describe the pharmacokinetics and evaluate the analgesic efficacy of buprenorphine (Simbadol, 1.8 mg/mL) administered by different routes in dogs undergoing ovariohysterectomy. Twenty-four dogs were included in a randomized, prospective, masked, clinical t...
Published in Journal of Neuroinflammation
BackgroundComplex regional pain syndrome type-I (CRPS-I) is a progressive and devastating pain condition. The mechanisms of CRPS-I still remain poorly understood. We aim to explore expression profiles of genes relevant to pain and neuroinflammation mechanisms involved in CRPS-I.MethodsThe rat chronic post-ischemic pain (CPIP) model that mimics huma...
Prism files containing all the raw data that support the 4 figures in the main manuscript and the supplementary data. This includes, the raw Ca2+-imaging and electrophysiology records for example traces, densitometry raw data for electrophoresis image and analysis and full overview of all statistical analysis present.
Published in Health and Quality of Life Outcomes
BackgroundThe EQ-5D domain pain/discomfort (PD) uses one item to capture pain and other aspects of discomfort, like itching. This study explored how pain, itching and the EQ-5D-5L PD domain relate to each other in a sample of burn patients.MethodsAdult burn patients completed the EQ-5D-5L and the Patient and Observer Scar Assessment Scale (POSAS) 5...
Published in Journal of NeuroEngineering and Rehabilitation
BackgroundApart from biomechanical alterations in movement patterns, it is known that movement limitations in persons with knee osteoarthritis (PwKOA) are related to an individual’s perception and belief regarding pain and disability. To gain more insights into the functional movement behaviour of PwKOA in a clinical setting, inertial sensor techno...
Published in Clinical oral investigations
The aim of this study was to compare the effects of AFG and i-PRF on palatal wound healing and postoperative discomfort. Thirty-six patients in need of FGG were divided into three groups. AFG (n = 12) or i-PRF (n = 12) was applied and compared with control group (n = 12). Wound healing with H2O2 test, VAS, MSS, and LTH index were evaluated on the 3...
Published in Pflugers Archiv : European journal of physiology
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed as four different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems. In the voltage range of activation, HCN channels carry an inward current mediated by Na+ and K+, termed If in the heart and Ih in neurons. Altered function of HCN channe...
