Komal, Nanda, Bibhu Prasad Singh, Lovekesh Bhatia, Rohit Singh, Amandeep
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Paclitaxel, a potent chemotherapeutic agent derived from the bark of the Pacific yew tree, has demonstrated significant efficacy in the treatment of various cancers, including colon cancer. This comprehensive review delves into the conventional treatments for colon cancer, emphasizing the crucial role of paclitaxel in contemporary management strate...
Borazanci, Erkut Bahary, Nathan Chung, Vincent Huyck, Timothy Kio, Ebenezer Chiorean, Elena Skeel, Roland Alese, Olatunji Cardin, Dana Fountzilas, Christos
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BACKGROUND: Modulation of glucocorticoid receptor (GR) activity in tumor cells enhances chemotherapy efficacy. We evaluated the selective GR modulator relacorilant plus nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) who had received at least 2 prior therapy lines. PATIENTS AND METHODS: In this open-label, single...
Tarantino, Paolo Tayob, Nabihah Villacampa, Guillermo Dang, Chau Yardley, Denise Isakoff, Steven Valero, Vicente Faggen, Meredith Mulvey, Therese Bose, Ron
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PURPOSE: Long-term outcomes of patients with stage I human epidermal growth factor receptor 2 (HER2)-positive breast cancer receiving adjuvant trastuzumab emtansine (T-DM1) remain undefined, and prognostic predictors represent an unmet need. METHODS: In the ATEMPT phase II trial, patients with stage I centrally confirmed HER2-positive breast cancer...
Putra, Andika Gerwindrawan, Amadisto Budiono, Eko Purwanto Utomo, Bambang Afifah, Naela Himayati Sumpono, Auliya Suluk Brilliant Pradjatmo, Heru Purwanto, Ibnu
Published in
Case Reports in Oncology
Introduction: Cancers of unknown primary (CUPs) present a diagnostic challenge as their origin is unidentified at diagnosis. Massive pleural effusion (MPE), indicative of lung metastasis in CUP, categorizes the condition into an unfavorable subset with a poor prognosis. Patients in this subset may exhibit a lower response to specific therapies. Cas...
Gupta, Anuradha Niveria, Karishma Chandpa, Hitesh Harsukhbhai Singh, Mamta Kumar, Vikas Panda, Amulya Kumar Meena, Jairam
Published in
Drug delivery and translational research
Chemotherapy and immunotherapy are two important modalities in cancer management. However, due to multiple reasons, a monotherapy is only partially effective. Hence, if used concurrently in targeted and stimuli-responsive manner, it could have been superior therapeutically. To facilitate co-delivery of chemotherapeutic and immunotherapeutic agent t...
Scheck, Magdalena K. Goetze, Thorsten O. Ettrich, Thomas J. Schmalenberg, Harald Clemens, Michael Mahlberg, Rolf Heeg, Steffen Kanzler, Stephan Hapke, Gunnar Thuss-Patience, Peter
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Published in
Oncology Research and Treatment
Metastatic and unresectable ESCCs still show poor prognosis. After failure or intolerance to first-line therapy, treatment options are limited and checkpoint inhibitors are the only approved therapeutic option. Our study adds further evidence to the use of antiangiogenic drugs in second-line treatment of advanced ESCC. Ramucirumab in combination wi...
Riazi-Tabrizi, Negin Khalaj-Kondori, Mohammad Safaei, Sahar Amini, Mohammad Hassanian, Hamidreza Maghsoudi, Mohadeseh Hasani, Shima Baradaran, Behzad
Published in
Molecular biotechnology
Pancreatic cancer is one of the most deadly diseases, with a very high metastasis and low survival rate. High levels of NRF2 have been detected in numerous malignancies, including head, neck, lung, and colon cancers, promoting the expansion and survival of cancer cells and chemical resistance to stressful conditions and affecting the response to tr...
Wang, Xuedong Li, Ping Zhang, Ziyun Wang, Xinping Jian, Qiwei Wang, Yueping
Published in
Experimental cell research
Chemoresistance is a significant obstacle in the treatment of breast cancer (BC). Due to its diverse composition, the causes of chemoresistance in BC are complex and have not been completely understood. In this article, we explored the mechanism of N6-methyladenosine (m6A)-modified long intervening noncoding RNA (linc)-OIP5 in BC chemoresistance. W...
Stockwell, Simon R Scott, Duncan E Fischer, Gerhard Guarino, Estrella Rooney, Timothy PC Feng, Tzu-Shean Moschetti, Tommaso Srinivasan, Rajavel Alza, Esther Asteian, Alice
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Aurora A kinase, a cell division regulator, is frequently overexpressed in various cancers, provoking genome instability and resistance to antimitotic chemotherapy. Localization and enzymatic activity of Aurora A are regulated by its interaction with the spindle assembly factor TPX2. We have used fragment-based, structure-guided lead discovery to d...
Wang, Lei Zhao, Gang Fang, Hong Deng, Pengcheng
Published in
Asian journal of surgery
