Goldfarb, David G Putman, Barbara Lahousse, Lies Zeig-Owens, Rachel Vaeth, Brandon M Schwartz, Theresa Hall, Charles B Prezant, David J Weiden, Michael D
Published in
American journal of industrial medicine
Greater than average loss of one-second forced expiratory volume (FEV1 ) is a risk factor for asthma, chronic obstructive pulmonary disease (COPD), and asthma/COPD overlap syndrome in World Trade Center (WTC)-exposed firefighters. Inhaled corticosteroids and long-acting beta agonists (ICS/LABA) are used to treat obstructive airways disease but thei...
Vanoverschelde, Anna van der Wel, Paulien Putman, Barbara Lahousse, Lies
Background: Correct inhaler use can be challenging in real life, with incorrect use resulting in poor symptom control. The aim of this study was to examine factors associated with poor inhaler technique and poor therapy adherence among patients with obstructive lung disease in community pharmacies. Methods: A cross-sectional study was conducted in ...
Probst-Hensch, N Jeong, A Stolz, D Pons, M Soccal, PM Bettschart, R Jarvis, D Holloway, JW Kronenberg, F Imboden, M
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Obesity has complex links to respiratory health. Mendelian randomization (MR) enables assessment of causality of body mass index (BMI) effects on airflow obstruction and mid-expiratory flow. In the adult SAPALDIA cohort, recruiting 9,651 population-representative samples aged 18–60 years at baseline (female 51%), BMI and the ratio of forced expirat...
Finney, L Glanville, N Farne, H Aniscenko, J Fenwick, P Kemp, S Trujillo Torralbo, M Loo, SL Calderazzo, M Wedzicha, J
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Background: The mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled corticosteroids (ICS) are widely used in COPD but the extent to which these therapies protect or expose ...
Ikram, M. Arfan Brusselle, Guy Ghanbari, Mohsen Goedegebure, Andre Ikram, M. Kamran Kavousi, Maryam Kieboom, Brenda C. T. Klaver, Caroline C. W. de Knegt, Robert J. Luik, Annemarie I.
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The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurologica...
Rodrigues, Fernanda Machado Demeyer, Heleen Loeckx, Matthias Hornikx, Miek Van Remoortel, Hans Janssens, Wim Troosters, Thierry
Published in
Respiratory Research
BackgroundPatients with COPD need to cope with a disabling disease, which leads to health status impairment.AimTo investigate the long term change of health status in subjects with mild to moderate airflow obstruction and to compare this to subjects without airflow obstruction, with and without a smoking history. Second, to investigate the factors ...
Doyle, LW Andersson, S Bush, A Cheong, JLY Clemm, H Evensen, KAI Gough, A Halvorsen, T Hovi, P Kajantie, E
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Background Maximal expiratory airflow peaks early in the third decade of life, then gradually declines with age. The pattern of airflow through adulthood for individuals born very preterm (at 2499 g) or at term. Methods We did a meta-analysis of individual participant data from cohort studies, mostly from the pre-surfactant era. Studies were identi...
van der Plaat, Diana A. Vonk, Judith M. Lahousse, Lies de Jong, Kim Faiz, Alen Nedeljkovic, Ivana Amin, Najaf van Diemen, Cleo C. Brusselle, Guy G. Bossé, Yohan
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Published in
BMC Pulmonary Medicine
BackgroundAirflow obstruction is a hallmark of chronic obstructive pulmonary disease (COPD), and is defined as either the ratio between forced expiratory volume in one second and forced vital capacity (FEV1/FVC)
Singh, D Agusti, A Anzueto, A Barnes, PJ Bourbeau, J Celli, BR Criner, GJ Frith, P Halpin, DMG Han, M
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Precision medicine is a patient specific approach that integrates all relevant clinical, genetic and biological information in order to optimise the therapeutic benefit relative to the possibility of side effects for each individual. Recent clinical trials have shown that higher blood eosinophil counts are associated with a greater efficacy of inha...
Svanes, Øistein Bertelsen, Randi J Lygre, Stein H L Carsin, Anne E Antó, Josep M Forsberg, Bertil García-García, José M Gullón, José A Heinrich, Joachim Holm, Mathias
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Published in
American journal of respiratory and critical care medicine
Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional cleaners and in persons cleaning at home has been reported. Long-term consequences of cleaning agents on respiratory health are, however, not well described. This stu...
