Van Dingenen, Jonas Pieters, Leen Van Nuffel, Elien Lefebvre, Romain A
Published in
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Postoperative ileus (POI), the impairment of gastrointestinal motility after abdominal surgery, is mainly due to intestinal muscular inflammation. Carbon monoxide (CO)-releasing compounds were shown to exert an anti-inflammatory effect in murine POI partially through induction of heme oxygenase-1 (HO-1). The influence of hemin and dimethyl fumarate...
Tran, Thi Ngoc Phuong Kumar, Vikash Bossier, Peter
Gram-negative marine bacterium Vibrio parahaemolyticus is an important aquatic pathogen and has been demonstrated to be the causative agent of acute hepatopancreatic necrotic disease (AHPND) in shrimp aquaculture. The AHPND-causing V. parahaemolyticus strains contain a pVA1 plasmid encoding the binary PirAVP and PirBVP toxins, are the primary virul...
Iryani, Mat Taib Mimi MacRae, Thomas H Sorgeloos, Patrick Muhammad, Tengku Sifzizul Tengku Danish-Daniel, Muhd Tan, Min Pau Satyantini, Woro Hastuti Wahid, Mohd Effendy Abd Sun, Jingfeng Lv, Aijun
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Brine shrimp Artemia franciscana release either encysted embryos via oviparous reproduction or motile nauplii via ovoviviparous reproduction. Artemia cysts contain an abundant amount of ArHsp21, ArHsp22, artemin, and p26, small heat shock proteins which regulate diapause and stress tolerance of this branchiopod crustacean. However, not much is know...
Kumar, Vikash Bels, Lobke De Couck, Liesbeth Baruah, Kartik Bossier, Peter den Broeck, Wim Van
Published in
Toxins
Acute hepatopancreatic necrosis disease (AHPND), a newly emergent farmed penaeid shrimp bacterial disease originally known as early mortality syndrome (EMS), is causing havoc in the shrimp industry. The causative agent of AHPND was found to be a specific strain of bacteria, e.g., Vibrio and Shewanella sps., that contains pVA1 plasmid (63–70 kb) enc...
Van Dingenen, Jonas Pieters, Leen Vral, Anne Lefebvre, Romain
Objective: Intestinal inflammation triggers postoperative ileus (POI), commonly seen after abdominal surgery and characterized by impaired gastrointestinal transit; when prolonged, this leads to increased morbidity. Hydrogen sulfide (H2S) is recognized as an important mediator of many (patho) physiological processes, including inflammation, and is ...
Alfama Lopes Dos Santos, Ruy Miguel Groot, Ruben Sui, Liying Bossier, Peter Van Stappen, Gilbert
Artemia cysts are highly demanded by the aquaculture industry to be hatched into nauplii and used as live food for larvae of most farmed fish and shellfish species. In recent years, pond production of Artemia cysts has been proposed as an effective measure to reduce the high dependence of the industry on cysts harvested from wild populations. Nonet...
Staels, Willem; Verdonck, Yannick; Heremans, Yves; Leuckx, Gunter; De Groef, Sofie; 119191; Heirman, Carlo; de Koning, Eelco; Gysemans, Conny; 24364; Thielemans, Kris; Baeyens, Luc;
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AIMS/HYPOTHESIS: The initial avascular period following islet transplantation seriously compromises graft function and survival. Enhancing graft revascularisation to improve engraftment has been attempted through virus-based delivery of angiogenic triggers, but risks associated with viral vectors have hampered clinical translation. In vitro transcr...
Staels, Willem Verdonck, Yannick Heremans, Yves Leuckx, Gunter De Groef, Sofie Heirman, Carlo de Koning, Eelco Gysemans, Conny Thielemans, Kris Baeyens, Luc
...
Published in
Diabetologia
Aims/hypothesisThe initial avascular period following islet transplantation seriously compromises graft function and survival. Enhancing graft revascularisation to improve engraftment has been attempted through virus-based delivery of angiogenic triggers, but risks associated with viral vectors have hampered clinical translation. In vitro transcrib...
Canli, Özge Alankuş, Yasemin B Grootjans, Sasker Vegi, Naidu Hültner, Lothar Hoppe, Philipp S Schroeder, Timm Vandenabeele, Peter Bornkamm, Georg W Greten, Florian R
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Maintaining cellular redox balance is vital for cell survival and tissue homoeostasis because imbalanced production of reactive oxygen species (ROS) may lead to oxidative stress and cell death. The antioxidant enzyme glutathione peroxidase 4 (Gpx4) is a key regulator of oxidative stress-induced cell death. We show that mice with deletion of Gpx4 in...
Carrette, Lieselot Madder, Annemieke
We have previously developed a crosslinking methodology for oligonucleotides based on the incorporation of furan moieties, which can be selectively oxidised to reactive intermediates that will quickly react with the opposite bases in DNA, forming toxic interstrand crosslinks (ICLs). Furan moieties also occur in natural DNA, as a result of oxidative...
