He, Dan Wang, Hui Dong, Ying Zhang, Yan Zhao, Jian Lv, Conghui Zheng, Xianjing Li, Dong Li, Ting
Published in
Gynecologic oncology
POLE mutation is a prognostic marker associated with excellent outcome in endometrial carcinoma (EC). However, these EC tumors frequently have aggressive histology. The aim of this study was to determine how to integrate the implications of POLE mutations into existing risk assessment strategies and further stratify patients. We detected POLE mutat...
Maksymowych, Walter P FitzGerald, Oliver Østergaard, Mikkel Homik, Joanne van der Heijde, Désirée Lambert, Robert G Elkayam, Ori Ramiro, Sofia Thorne, J Carter Larché, Maggie J
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Published in
The Journal of rheumatology
The Outcome Measures in Rheumatology Soluble Biomarker Working Group initiated an international, multicenter, prospective study, the Rheumatoid Arthritis (RA) BIODAM cohort, to generate resources for the clinical validation of candidate biomarkers predictive of radiographic progression. This first report describes the cohort, clinical outcomes, and...
De Canniere, Helene; Smeets, Christophe JP; Schoutteten, Melanie; Varon, Carolina; 73785; Van Hoof, Chris; 12734; Van Huffel, Sabine; 13262; Groenendaal, Willemijn; Vandervoort, Pieter;
BACKGROUND: Cardiac rehabilitation (CR) is known for its beneficial effects on functional capacity and is a key component within current cardiovascular disease management strategies. In addition, a larger increase in functional capacity is accompanied by better clinical outcomes. However, not all patients respond in a similar way to CR. Therefore, ...
Marcelis, Lukas; 109931; Antoranz, Asier; Delsupehe, Anne-Marie; Biesemans, Pauline; Ferreiro, Julio Finalet; Debackere, Koen; 62120; Vandenberghe, Peter; 5254; Verhoef, Gregor; Gheysens, Olivier; Cattoretti, Giorgio;
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Primary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin lymphoma with an aggressive clinical course. To investigate the potential of immune-checkpoint therapy, we retrospectively studied the tumor microenvironment (TME) using high-plex immunohistochemistry in 22 PCNSL and compared to 7 secondary CNS lymphomas (SCNSL) and 7 "ot...
Gatselis, Nikolaos K Goet, Jorn C Zachou, Kalliopi Lammers, Willem J Janssen, Harry L A Hirschfield, Gideon Corpechot, Christophe Lindor, Keith D Invernizzi, Pietro Mayo, Marlyn J
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Published in
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Patients usually receive a diagnosis of primary biliary cholangitis (PBC) at an early stage, based on biochemical analyses. We investigated the proportion of patients who progress to moderate or advanced PBC and factors associated with progression and patient survival. We obtained data from 1615 patients (mean age, 55.4 y) with early stage PBC (bas...
He, Yanru Lv, Naqiang Dang, Aimin Cheng, Nan
Published in
The Journal of rheumatology
This study was performed to explore the clinical manifestations and longterm prognosis in patients with Takayasu arteritis (TA) with pulmonary artery involvement (PAI). The medical records of 194 patients with TA who underwent traditional catheter angiography or computed tomography of pulmonary artery from 2009 to 2016 were retrospectively reviewed...
Ungar, Andrea Rivasi, Giulia Petrovic, Mirko Schönenberger, Andreas Martínez-Sellés, Manuel Gasowski, Jerzy Bahat-Ozturk, Gülistan Bo, Mario Dallmaier, Dhayana Fumagalli, Stefano
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Cardiovascular diseases (CVD) are highly prevalent in older adults and represent a major geriatric health-care concern. Management of CVD in older patients may be challenging due to specific geriatric issues, such as frailty and multi-morbidity, which may influence patients’ outcomes. In this clinical context, diagnostic and therapeutic strategies ...
Dullaert, Matthias Oerlemans, Joyce De Paepe, Peter Kalala Okito, Jean-Pierre Hallaert, Giorgio
OBJECTIVE: The aim of this retrospective study was to externally validate the CRASH (Corticosteroid Randomisation After Significant Head Injury) clinical calculator as a prognostic tool. Mortality at 14 days and an unfavorable outcome (i.e., Glasgow Outcome Scale score = 4 at 6 months. Receiver operating characteristic analysis showed an area under...
Lateb, Maël Ouahmi, Hajar Payré, Christine Brglez, Vesna Zorzi, Kevin Dolla, Guillaume Zaidan, Mohamad Boyer-Suavet, Sonia Knebelmann, Bertrand Crépin, Thomas
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Published in
Journal of Immunology Research
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic membranous nephropathy (MN). However, the pathogenic role of anti-PLA2R1 autoantibodies is unclear. Our aim was to evaluate the in vitro cytotoxicity of anti-PLA2R1 antibodies mediated by complement. Forty-eight patients with PLA2R1-related MN from the prospective cohort ...
Casabonne, D Benavente, Y Seifert, J Costas, L Armesto, M Arestin, M Besson, C Hosnijeh, FS Duell, EJ Weiderpass, E
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Chronic lymphocytic leukemia (CLL) is an incurable disease accounting for almost one-third of leukemias in the Western world. Aberrant expression of microRNAs (miRNAs) is a well-established characteristic of CLL, and the robust nature of miRNAs makes them eminently suitable liquid biopsy biomarkers. Using a nested case-control study within the Euro...
