19F-MRI and numerical modeling as a combined method for the measurement and prediction of fluorinated substances (e.g. P...
EGU General Assembly 2022, VIENNE, AUTRICHE, 23-/05/2022 - 27/05/2022
Recent biomonitoring reports on phosphate ester flame retardants: a short review
Published in Archives of Toxicology
Organophosphate triesters (PEFRs) are used increasingly as flame retardants and plasticizers in a variety of applications, such as building materials, textiles, and electric and electronic equipment. They have been proposed as alternatives to brominated flame retardants. This updated review shows that biomonitoring has gained incrementally greater ...
Bladder cancer and occupational exposure to metalworking fluid mist: a counter-matched case–control study in French stee...
Objectives: To assess the relationship between occupational exposure to metalworking fluids (MWFs) in the steel-producing industry and bladder cancer incidence. Methods: A nested case–control study on bladder cancer was set up in a cohort of workers from six French steel-producing factories. Three controls were randomly selected for each incident b...
Use of the kurtosis statistic in an evaluation of the effects of noise and solvent exposures on the hearing thresholds o...
Published in The Journal of the Acoustical Society of America
The aim of this exploratory study was to examine whether the kurtosis metric can contribute to investigations of the effects of combined exposure to noise and solvents on human hearing thresholds. Twenty factory workers exposed to noise and solvents along with 20 workers of similar age exposed only to noise in eastern China were investigated using ...
Study of potential transfer of aluminum to the brain via the olfactory pathway
Many employees in the aluminum industry are exposed to a range of aluminum compounds by inhalation, and the presence of ultrafine particles in the workplace has become a concern to occupational health professionals. Some metal salts and metal oxides have been shown to enter the brain through the olfactory route, bypassing the blood-brain barrier, b...
In vitro cell transformation induced by synthetic amorphous silica nanoparticles.
Published in Mutation research. Genetic toxicology and environmental mutagenesis
Synthetic amorphous silica nanoparticles (SAS) are among the most widely produced and used nanomaterials, but little is known about their carcinogenic potential. This study aims to evaluate the ability of four different SAS, two precipitated, NM-200 and NM-201, and two pyrogenic, NM-202 and NM-203, to induce the transformation process. For this, we...
Epigenetic changes in the early stage of silica-induced cell transformation.
Published in Nanotoxicology
The increasing use of nanomaterials in numerous domains has led to growing concern about their potential toxicological properties, and the potential risk to human health posed by silica nanoparticles remains under debate. Recent studies proposed that these particles could alter gene expression through the modulation of epigenetic marks, and the pos...
Brain Inflammation, Blood Brain Barrier dysfunction and Neuronal Synaptophysin Decrease after Inhalation Exposure to Tit...
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Published in Scientific Reports
Notwithstanding potential neurotoxicity of inhaled titanium dioxide nanoparticles (TiO2 NPs), the toxicokinetics and consequences on blood-brain barrier (BBB) function remain poorly characterized. To improve risk assessment, we need to evaluate the impact on BBB under realistic environmental conditions and take into account vulnerability status suc...
Médicaments anticancéreux et médecine vétérinaire. Retour d'expérience du Centre hospitalier universitaire vétérinaire d...
Le développement des chimiothérapies en médecine vétérinaire expose le personnel à des risques de contamination par les médicaments cytotoxiques. Après une campagne de prélèvements surfaciques montrant une contamination de l'environnement et une exposition des personnels, en particulier au niveau des gants, le Centre hospitalier universitaire vétér...
Toluene and methylethylketone: effect of combined exposure on their metabolism in rat.
...Published in Xenobiotica; the fate of foreign compounds in biological systems
1. Multiple exposures are ubiquitous in industrial environments. In this article, we highlight the risks faced by workers and complete the data available on the metabolic impact of a common mixture: toluene (TOL) and methylethylketone (MEK). 2. Rats were exposed by inhalation under controlled conditions either to each solvent individually, or to mi...
