Stouten, Veerle Westhovens, René Pazmino, Sofia De Cock, Diederik Van der Elst, Kristien Joly, Johan Verschueren, Patrick
Published in
Rheumatology (Oxford, England)
To investigate whether MTX should be combined with an additional DMARD and bridging glucocorticoids as initial treatment for patients with early RA to induce an effective long-term response. The Care in early RA study is a two-year investigator-initiated pragmatic multicentre randomized trial. Early RA patients, naïve to DMARDs and glucocorticoids,...
Stouten, Veerle; 106536; Westhovens, Rene; 8450; Pazmino, Sofia; 112172; De Cock, Diederik; 71992; Van der Elst, Kristien; 83686; Joly, Johan; Verschueren, Patrick; 4770; Maeyaert, B; De Brabanter, G; Devinck, M;
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OBJECTIVES: To investigate whether MTX should be combined with an additional DMARD and bridging glucocorticoids as initial treatment for patients with early RA to induce an effective long-term response. METHODS: The Care in early RA study is a two-year investigator-initiated pragmatic multicentre randomized trial. Early RA patients, naïve to DMARDs...
Choudhury, Sirazum Lightman, Stafford Meeran, Karim
Published in
Clinical endocrinology
There is an increased mortality associated with adrenal insufficiency despite glucocorticoid replacement therapy with a standardized mortality ratio greater than two. The cause of the increased mortality is yet to be definitively elucidated, but may be due to excess steroid exposure, or replacement regimens that are uncoupled from the normal physio...
Vergis, N Thursz, M Atkinson, S
Severe alcoholic hepatitis (SAH) is a condition characterized by jaundice and liver failure that develops after heavy and prolonged alcohol consumption. Infection frequently complicates the natural history of the disease and is independently associated with mortality. Objective recognition and recording of infection are therefore essential in the e...
Webb, Nicholas Ja Woolley, Rebecca L Lambe, Tosin Frew, Emma Brettell, Elizabeth A Barsoum, Emma N Trompeter, Richard S Cummins, Carole Wheatley, Keith Ives, Natalie J
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Published in
Health technology assessment (Winchester, England)
Steroid-sensitive nephrotic syndrome (SSNS) is one of the most common childhood kidney diseases. The kidney filters leak protein into the urine, resulting in low levels of protein in the blood and generalised swelling. If untreated, this can lead to serious complications, including infection and blood clots. The disease responds well to prednisolon...
Hofmans, Mattias Suciu, Stefan Ferster, Alina Van Vlierberghe, Pieter Mazingue, Françoise Sirvent, Nicolas Costa, Vitor Yakouben, Karima Paillard, Catherine Uyttebroeck, Anne
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Outcomes in childhood T‐cell acute lymphoblastic leukaemia (T‐ALL) are steadily improving due to intensive therapy. Between 1989 and 2008, 599 children with newly diagnosed T‐ALL were enrolled in two successive European Organization for Research and Treatment of Cancer ‐ Children's Leukaemia Group trials (58881 and 58951), both based on the Berlin‐...
Potts, Jonathan R Farahi, Neda Howard, Mark R Taylor, Mark R Heard, Sarah Shankar, Arun N Alexander, Graeme J Chilvers, Edwin R Verma, Sumita Peters, A Michael
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Published in
Bioscience reports
The study's aim was to image severe alcoholic hepatitis (SAH) using 111In-labelled leucocytes with two objectives in mind: firstly for non-invasive diagnosis and secondly to provide a platform for experimental therapies aiming to inhibit intrahepatic neutrophil migration. 111In-leucocyte scintigraphy was performed 30 min and 24 h post-injection in ...
Saglani, Sejal Rosenthal, Mark Bush, Andrew
Published in
The Lancet. Respiratory medicine
Louvet, A Thursz, MR Kim, DJ Labreuche, J Atkinson, S Sidhu, SS O'Grady, JG Akriviadis, E Sinakos, E Carithers, RL
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BACKGROUND & AIMS: We performed a meta-analysis of individual patient data from 11 randomized controlled trials comparing corticosteroids, pentoxifylline, or their combination in patients with severe alcoholic hepatitis. We compared the effects of the treatments on survival for 28 days or 6 months, and response to treatment based on the Lille model...
Cornelis, I Volk, H A Van Ham, L De Decker, S
Published in
Veterinary journal (London, England : 1997)
Although long-term outcomes of meningoencephalitis of unknown aetiology (MUA) in dogs have been evaluated, little is known about short-term survival and initial response to therapy. The aim of this study was to evaluate possible prognostic factors for 7-day survival after diagnosis of MUA in dogs. Medical records were reviewed for dogs diagnosed wi...
