Sakudo, Akikazu Imanishi, Yuichiro Hirata, Azumi Koga, Yuichi Shintani, Hideharu
Published in
Pathogens
Previous studies show that nitrogen gas plasma generated by a fast-pulsed power supply using a static induction thyristor has both virucidal and bactericidal effects. In this study, nitrogen gas plasma was further evaluated for its potential effects on prions, which are well known to be the most resistant pathogen to both chemical and physical inac...
O’Day, Danton H.
Published in
International Journal of Molecular Sciences
The integral role of calmodulin in the amyloid pathway and neurofibrillary tangle formation in Alzheimer’s disease was first established leading to the “Calmodulin Hypothesis”. Continued research has extended our insight into the central function of the small calcium sensor and effector calmodulin and its target proteins in a multitude of other eve...
Bruce, Jason I. E. James, Andrew D.
Published in
Cancers
Cancer is caused by excessive cell proliferation and a propensity to avoid cell death, while the spread of cancer is facilitated by enhanced cellular migration, invasion, and vascularization. Cytosolic Ca2+ is central to each of these important processes, yet to date, there are no cancer drugs currently being used clinically, and very few undergoin...
Zhou, Dong-Hua Wang, Jing Xiao, Kang Wu, Yue-Zhang Maimaitiming, Adalaiti Hu, Chao Gao, Li-Ping Chen, Jia Gao, Chen Chen, Cao
...
Published in
ACS chemical neuroscience
Resveratrol shows the ability to block prion replication in a scrapie-infected cell line, SMB-S15, and remove the infectivity of the treated cell lysates in an experimental bioassay. In this study, we compared the effectiveness of three stilbene compounds, resveratrol (Res), pterostilbene (Pte), and piceatannol (Pic), on inhibiting prion propagatio...
Richardson, D. A. Sritangos, P. James, A. D. Sultan, A. Bruce, J. I. E.
Published in
Cancer & Metabolism
BackgroundHigh glycolytic rate is a hallmark of cancer (Warburg effect). Glycolytic ATP is required for fuelling plasma membrane calcium ATPases (PMCAs), responsible for extrusion of cytosolic calcium, in pancreatic ductal adenocarcinoma (PDAC). Phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3) is a glycolytic driver that activates key rate-li...
Eraña, Hasier Charco, Jorge M. González-Miranda, Ezequiel García-Martínez, Sandra López-Moreno, Rafael Pérez-Castro, Miguel A. Díaz-Domínguez, Carlos M. García-Salvador, Adrián Castilla, Joaquín
Published in
Biomolecules
Transmissible spongiform encephalopathies or prion diseases are rapidly progressive neurodegenerative diseases, the clinical manifestation of which can resemble other promptly evolving neurological maladies. Therefore, the unequivocal ante-mortem diagnosis is highly challenging and was only possible by histopathological and immunohistochemical anal...
Giaccone, Giorgio Moda, Fabio
Published in
Biomolecules
Prion diseases are neurodegenerative and invariably fatal conditions that affect humans and animals. In particular, Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy (BSE) are paradigmatic forms of human and animal prion diseases, respectively. Human exposure to BSE through contaminated food caused the appearance of the new varia...
Angenendt, Adrian Steiner, Romy Knörck, Arne Schwär, Gertrud Konrad, Maik Krause, Elmar Lis, Annette
Published in
Aging (Albany NY)
Ca2+ is a crucial second messenger for proper T cell function. Considering the relevance of Ca2+ signals for T cell functionality it is surprising that no mechanistic insights into T cell Ca2+ signals from elderly individuals are reported. The main Ca2+ entry mechanism in T cells are STIM-activated Orai channels. Their role during lymphocyte aging ...
Ugalde, Cathryn L Annesley, Sarah J Gordon, Shane E Mroczek, Katelyn Perugini, Matthew A Lawson, Victoria A Fisher, Paul R Finkelstein, David I Hill, Andrew F
Published in
Disease models & mechanisms
The misfolding and aggregation of the largely disordered protein, α-synuclein, is a central pathogenic event that occurs in the synucleinopathies, a group of neurodegenerative disorders that includes Parkinson's disease. While there is a clear link between protein misfolding and neuronal vulnerability, the precise pathogenic mechanisms employed by ...
Cazzaniga, Federico Angelo De Luca, Chiara Maria Giulia Bistaffa, Edoardo Consonni, Alessandra Legname, Giuseppe Giaccone, Giorgio Moda, Fabio
Published in
Progress in molecular biology and translational science
Neurodegenerative diseases (NDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), atypical parkinsonisms, frontotemporal dementia (FTLD) and prion diseases are characterized by the accumulation of misfolded proteins in the central nervous system (CNS). Although the cause for the initiation of protein aggregation is not well understood, t...
