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Volik, Pavel I Kopeina, Gelina S Zhivotovsky, Boris Zamaraev, Alexey V
Published in
Trends in molecular medicine
The PIDDosome is a multiprotein complex that includes p53-induced protein with a death domain 1 (PIDD1), receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD), and caspase-2, the activation of which is driven by PIDDosome assembly. In addition to the key role of the PIDDosome in the regulation of cell di...
Huang, Yilin Liu, Huisheng Hu, Jiaqi Han, Chongyin Zhong, Zhenggang Luo, Wei Zhang, Yuhu Ling, Fei
Published in
Frontiers in Aging Neuroscience
Parkinson’s disease (PD) is the second most neurodegenerative disease in the world. T cell infiltration in the central nervous system (CNS) has provided insights that the peripheral immune cells participate in the pathogenesis of PD. However, the association between the peripheral immune system and CNS remains to be elucidated. In this study, we an...
Shah, Richa B Kernan, Jennifer L van Hoogstraten, Anya Ando, Kiyohiro Li, Yuanyuan Belcher, Alicia L Mininger, Ivy Bussenault, Andrei M Raman, Renuka Ramanagoudr-Bhojappa, Ramanagouda
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Published in
Developmental cell
Cells counter DNA damage through repair or apoptosis, yet a direct mechanism for this choice has remained elusive. When facing interstrand crosslinks (ICLs), the ICL-repair protein FANCI heterodimerizes with FANCD2 to initiate ICL excision. We found that FANCI alternatively interacts with a pro-apoptotic factor, PIDD1, to enable PIDDosome (PIDD1-RA...
Chai, Wei-Na Wu, Yi-Fan Wu, Zhi-Min Xie, Yan-Feng Shi, Quan-Hong Dan, Wei Zhan, Yan Zhong, Jian-Jun Tang, Wei Sun, Xiao-Chuan
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Published in
Neural Regeneration Research
Studies have shown that downregulation of nuclear-enriched autosomal transcript 1 (Neat1) may adversely affect the recovery of nerve function and the increased loss of hippocampal neurons in mice. Whether Neat1 has protective or inhibitory effects on neuronal cell apoptosis after secondary brain injury remains unclear. Therefore, the effects of Nea...
Sladky, Valentina Schuler, Fabian Fava, Luca L Villunger, Andreas
Published in
Journal of cell science
The PIDDosome is often used as the alias for a multi-protein complex that includes the p53-induced death domain protein 1 (PIDD1), the bipartite linker protein CRADD (also known as RAIDD) and the pro-form of an endopeptidase belonging to the caspase family, i.e. caspase-2. Yet, PIDD1 variants can also interact with a number of other proteins that i...
