Published in European journal of nuclear medicine and molecular imaging
In the context of the worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some patients report functional complaints after apparent recovery from COVID-19. This clinical presentation has been referred as "long COVID." We here present a retrospective analysis of 18F-FDG brain PET of long COVID patients from the same c...
Published in EJNMMI Research
BackgroundThe role of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in children is still expanding. Dedicated paediatric dosage regimens are needed to keep the radiation dose as low as reasonably achievable and reduce the risk of radiation-induced carcinogenesis. The aim of this study is to inv...
In 2018, the ‘Deltaplan Ruimtelijke Adaptatie’, has been set up by the National Institute of Health and Environment (RIVM) for the purpose of facilitating the transformation to a climate adaptive living environment. As part of the Deltaplan, municipalities have been asked to perform a heat risk assessment through standardised outdoor thermal comfor...
Published in Insights into Imaging
Lung cancer has the highest mortality rate of any tumour type. The main driver of lung tumour growth and development is uncontrolled cellular proliferation. Poor patient outcomes are partly the result of the limited range of effective anti-cancer therapies available and partly due to the limited accuracy of biomarkers to report on cell proliferatio...
Published in Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The mechanism of chronotropic incompetence (CTI), which has been associated with autonomic dysfunction, has not been elucidated in patients without heart failure (HF). Methods: Cardiac PET using 11C-CGP12177 was performed to investigate the cardiac β-adrenergic receptor density (β-ARD) in 13 patients with CTI without HF and 6 healthy controls. The ...
Published in European journal of nuclear medicine and molecular imaging
To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer's Disease (AD) Research Framework derived from [18F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181). We included 351 subjects with varying clinical diagnoses from three cohorts with available FT...
Published in Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Although cancer has been known for decades to harbor an insatiable appetite for iron, only recently has the chemistry emerged to exploit this altered state therapeutically, by targeting the expanded cytosolic labile iron pool (LIP) of the cancer cell. The state of the art includes therapies that react with the LIP to produce cytotoxic radical speci...
Published in Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The aim of this work was to explore 132La as a PET imaging surrogate for 225Ac using a DOTA-based, tumor-targeting alkylphosphocholine (NM600). Methods: 132La was produced on a biomedical cyclotron. For in vivo experiments, mice bearing 4T1 tumors were administered 132La-NM600, and PET/CT scans were acquired up to 24 h after injection. After the la...
Published in Current Cardiology Reports
Purpose of ReviewTo examine the use of positron emission tomography (PET) for imaging post-infarct myocardial inflammation and repair.Recent FindingsDysregulated immune responses after myocardial infarction are associated with adverse cardiac remodelling and an increased likelihood of ischaemic heart failure. PET imaging utilising novel tracers can...
Published in Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The objective of this retrospective study was to assess the detection rate (DR), positive predictive value (PPV), and correct detection rate (CDR) of 18F-rhPSMA-7 PET/CT in biochemical recurrence (BCR) of prostate cancer (PCa) after radical prostatectomy (RP) using composite validation. Methods: 18F-rhPSMA-7 PET/CT scans of patients with BCR betwee...
