Development of fluorescent materials with high photostability and biocompatibility is of great importance in biolabeling and bio-imaging. Herein, we employ amphiphilic amino acids as basic building blocks to fabricate stable biology self-luminous nanoparticles with a uniform size distribution of 300 nm. The endogenous property of amino acids endows...
Development of fluorescent materials with high photostability and biocompatibility is of great importance in biolabeling and bio-imaging. Herein, we employ amphiphilic amino acids as basic building blocks to fabricate stable biology self-luminous nanoparticles with a uniform size distribution of 300 nm. The endogenous property of amino acids endows...
The functional activity and differentiation potential of cells are determined by their interactions with surrounding cells. Approaches that allow unbiased characterization of cell states while at the same time providing spatial information are of major value to assess this environmental influence. However, most current techniques are hampered by a ...
A series of multitarget-directed ligands (MTDLs) was designed by functionalizing a pseudo-irreversible butyrylcholinesterase (BChE) inhibitor. The obtained hybrids were investigated in vitro regarding their hBChE and hAChE inhibition, their enzyme kinetics, and their antioxidant physicochemical properties (DPPH, ORAC, metal chelating). In addition,...
Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility, multi-functionality, and physiochemical properties similar to those of body tissues. However, the preparation of such hydrogels featuring high conductivity and transparency ...
Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility, multi-functionality, and physiochemical properties similar to those of body tissues. However, the preparation of such hydrogels featuring high conductivity and transparency ...
Cells have evolved a complex molecular network, collectively called the protein homeostasis (proteostasis) network, to produce and maintain proteins in the appropriate conformation, concentration and subcellular localization. Loss of proteostasis leads to a reduction in cell viability, which occurs to some degree during healthy ageing, but is also ...
The combination of phage display technology with high-throughput sequencing enables in-depth analysis of library diversity and selection-driven dynamics. We applied short-read sequencing of the mutagenized region on focused display libraries of two homologous nucleic acid modification eraser proteins-AlkB and FTO-biopanned against methylated DNA. T...
Cyclic dipeptides (CDPs) are the smallest cyclic peptides containing 2,5-diketopiperazine rings. CDPs have advantages of structures and properties, including excellent hydrogen-bonding-forming ability (two hydrogen bonding acceptors and two hydrogen bonding donors), structural rigidity, and enzymatic stability, which make CDPs potential candidates ...
Insulin, a peptide hormone, is one of the most common and effective antidiabetic drugs. Although oral administration is considered to be the most convenient and safe choice for patients, the oral bioavailability of insulin is very low due to the poor oral absorption into blood circulation. Intestinal epithelium is a major barrier for the oral absor...
