Suay-Garcia, Beatriz Falcó, Antonio Bueso-Bordils, J Ignacio Anton-Fos, Gerardo M Pérez-Gracia, M Teresa Alemán-López, Pedro A
Published in
Pharmaceuticals (Basel, Switzerland)
Drug repurposing appears as an increasing popular tool in the search of new treatment options against bacteria. In this paper, a tree-based classification method using Linear Discriminant Analysis (LDA) and discrete indexes was used to create a QSAR (Quantitative Structure-Activity Relationship) model to predict antibacterial activity against Esche...
Wei, Jiangxue Li, Zhengjun Yang, Yanli Ma, Xiaowei An, Wenqi Ma, Guanghui Su, Zhiguo Zhang, Songping
Here we present a biomimetic strategy towards an influenza vaccine design based on hepatitis B virus core virus-like particles (HBc VLP). To this end, a temperature-shift based encapsulation process based on analysis of the unique thermal-associated structural flexibility of HBc VLP nanocages was proposed and proved efficient for encapsulation of a...
Yuan, Chengqian Yang, Mengyao Ren, Xiaokang Zou, Qianli Yan, Xuehai
Understanding and controlling multicomponent co-assembly is of primary importance in different fields, such as materials fabrication, pharmaceutical polymorphism, and supramolecular polymerization, but these aspects have been a long-standing challenge. Herein, we discover that liquid-liquid phase separation (LLPS) into ion-cluster-rich and ion-clus...
Yuan, Chengqian Yang, Mengyao Ren, Xiaokang Zou, Qianli Yan, Xuehai
Understanding and controlling multicomponent co-assembly is of primary importance in different fields, such as materials fabrication, pharmaceutical polymorphism, and supramolecular polymerization, but these aspects have been a long-standing challenge. Herein, we discover that liquid-liquid phase separation (LLPS) into ion-cluster-rich and ion-clus...
Ji, Mei Zhu, Jie Xie, Xi-xiu Liu, Dong-qun Wang, Bin Yu, Zhuo Liu, Rui-tian
Personalized cancer vaccine which targets neoepitopes shows great promise for cancer treatment. However, rapid preparation is a critical challenge for clinical application of personalized cancer vaccine. Genetic recombination and chemical modification are a time-consuming "trial and error" pattern for making vaccines. Here we first constructed a pl...
Driver, T Cooper, B Ayers, R Pipkorn, R Patchkovskii, S Averbukh, V Klug, D Marangos, J Frasinski, L Edelson-Averbukh, M
...
Covariance mapping [L. J. Frasinski, K. Codling, and P. A. Hatherly, Science 246, 1029 (1989)] is a well-established technique used for the study of mechanisms of laser-induced molecular ionization and decomposition. It measures statistical correlations between fluctuating signals of pairs of detected species (ions, fragments, electrons). A positiv...
An, Dongchen; 133863; Peigneur, Steve; 56122; Hendrickx, Louise Antonia; 126402; Tytgat, Jan; 18354;
Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying affinities relevant for the tr...
Fadda, Melissa; 105843; De Fruyt, Nathan; 116075; Borghgraef, Charline; Watteyne, Jan; 92882; Peymen, Katleen; Vandewyer, Elke; Naranjo Galindo, Francisco J; Kieswetter, Amanda; Mirabeau, Olivier; Chew, Yee Lian;
...
Aversive learning is fundamental for animals to increase chances of survival. In addition to classical neurotransmitters, neuropeptides have emerged to modulate such complex behaviors. Among them, neuropeptide Y (NPY) is well known to promote aversive memory acquisition in mammals. Here we identify an NPY/neuropeptide F (NPF)-related neuropeptide s...
Eggermont, Mieke Cornillie, Pieter Dierick, Manuel Adriaens, Dominique Nevejan, Nancy Bossier, Peter Van den Broeck, Wim Sorgeloos, Patrick Defoirdt, Tom Declercq, Annelies Maria
...
Published in
Scientific Reports
The blue mussel Mytilus edulis is an intensely studied bivalve in biomonitoring programs worldwide. The lack of detailed descriptions of hemolymph-withdrawal protocols, particularly with regard to the place from where hemolymph could be perfused from, raises questions regarding the exact composition of aspirated hemolymph and does not exclude the p...
Li, Hong Zhao, Jie Wang, Anhe Li, Qi Cui, Wei
Molecular self-assembly of functional proteins has garnered intense interest for the development of nanomaterials. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as one of the most promising agents for cancer therapy, could selectively induce the apoptotic cell death in tumor cells while not on normal cells. In this study, protein...
