Cox, Kristin E Turner, Michael A Lwin, Thinzar M Amirfakhri, Siamak Kelly, Kaitlyn J Hosseini, Mojgan Ghosh, Pradipta Obonyo, Marygorret Hoffman, Robert M Yazaki, Paul J
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BackgroundGastric cancer poses a major diagnostic and therapeutic challenge as surgical resection provides the only opportunity for a cure. Specific labeling of gastric cancer could distinguish resectable and nonresectable disease and facilitate an R0 resection, which could improve survival.MethodsTwo patient-derived gastric cancer lines, KG8 and K...
Doyle, Kathleen Hassan, Abd-Elrahman Sutter, Maria Rodriguez, Monica Kumar, Priyadarsini Brown, Erin
Background/aimNeuroblastoma is a common childhood cancer with poor survival for children with high-risk disease, and ongoing research to improve outcomes is needed. Patient-derived xenografts (PDX) and genetically engineered mouse models (GEMM) are reliable models for oncologic research; however, they are resource-intensive, expensive, and require ...
Devis-Jauregui, Laura Vidal, August Plata-Peña, Laura Santacana, Maria García-Mulero, Sandra Bonifaci, Nuria Noguera-Delgado, Eulàlia Ruiz, Nuria Gil, Marta Dorca, Eduard
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Published in
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Clinical management of endometrial cancer (EC) is handicapped by the limited availability of second line treatments and bona fide molecular biomarkers to predict recurrence. These limitations have hampered the treatment of these patients, whose survival rates have not improved over the last four decades. The advent of coordinated studies such as Th...
MASAKI, NORIYUKI HAN, QINGHONG WU, NATHANIEL F. SAMONTE, CARISSA WU, JUSTIN HOZUMI, CHIHIRO OBARA, KOYA KUBOTA, YUTARO AOKI, YUSUKE MIYAZAKI, JUN
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Published in
In Vivo
Background/Aim: Primary osteosarcoma of the mammary gland is a very rare disease, accounting for under 1% of all mammary gland malignancies. There is no established first-line treatment, and prognosis is poor compared to conventional breast cancer. We previously demonstrated the efficacy of cisplatinum and eribulin in a patient-derived orthotopic x...
MASAKI, NORIYUKI AOKI, YUSUKE KUBOTA, YUTARO OBARA, KOYA MIYAZAKI, JUN HOFFMAN, ROBERT M.
Published in
In Vivo
Background/Aim: Dedifferentiated liposarcoma (DDLS) is a type of soft-tissue sarcoma with a poor prognosis due to distant metastasis and resistance to chemotherapy. The antimalarial drug chloroquine (CQ) can induce apoptosis in cancer cells. CQ in combination with rapamycin (RAPA), an mTOR inhibitor, has shown efficacy on osteosarcoma and other typ...
Masaki, Noriyuki Han, Qinghong Samonte, Carissa Wu, Nathaniel F Hozumi, Chihiro Wu, Justin Obara, Koya Kubota, Yutaro Aoki, Yusuke Bouvet, Michael
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Published in
Anticancer research
Primary osteosarcoma of the breast is a very rare malignancy that shares histological features with osteosarcoma. It is also highly sensitive to methionine restriction due to methionine addiction. We previously established a patient-derived orthotopic xenograft (PDOX) nude-mouse model derived from tumor tissue of a patient with primary mammary oste...
chevaleyre;, céline
Diffuse intrinsic pontine gliomas (DIPG), the first cause of cerebral pediatric cancer death, will greatly benefit from specific and non-invasive biomarkers for patient follow-up and monitoring of drug efficacy. Since biopsies are challenging for brain tumors, molecular imaging may be a technique of choice to target and follow tumor evolution. So f...
Fernández-Rodríguez, Juana Creus-Bachiller, Edgar Zhang, Xiaohu Martínez-Iniesta, Maria Ortega-Bertran, Sara Guha, Rajarshi Thomas, Craig J. Wallace, Margaret R. Romagosa, Cleofe Salazar-Huayna, Lourdes
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Published in
Molecular cancer therapeutics
Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that are the leading cause of mortality in Neurofibromatosis type 1 (NF1) patients. Single chemotherapeutic agents have shown response rates ranging from 18–44% in clinical trials, so there is still a high medical need to identify chemotherapeutic combination treatments that...
Magouliotis, Dimitrios E Lafazanis, Kostas Koutsougianni, Fani Sakellaridis, Nikos Ioannou, Maria Zacharoulis, Dimitris Dimas, Konstantinos
Published in
In vivo (Athens, Greece)
Pancreatic cancer (PC) is one of the leading causes of cancer-related death. The purpose of the present study was to establish a patient-derived orthotopic xenograft model (PDOX) for pancreatic ductal adenocarcinoma (PDAC), thus providing a tumor microenvironment resembling that of the human pancreas to identify novel potential biomarkers and treat...
Ai, Xiaolin Ye, Zengpanpan Xiao, Chaoxin Zhong, Jian Lancman, Joseph J. Chen, Xuelan Pan, Xiangyu Yang, Yu Zhou, Lin Wang, Xiang
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Published in
Disease Models & Mechanisms
Editor's choice: We established zebrafish glioblastoma (GBM) xenograft models that can be used to perform genetic and biological analysis of GBMs, identify blood–brain barrier-penetrating drugs and predict clinical sensitivity to temozolomide in GBM patients.