Guo, Yanan Yan, Binjie Gui, Yu Tang, Zhihan Tai, Shi Zhou, Shenghua Zheng, Xi-Long
Published in
Journal of cellular physiology
Proprotein convertase subtilisin/kexin type-9 (PCSK9), a member of the proprotein convertase family, is an important drug target because of its crucial role in lipid metabolism. Emerging evidence suggests a direct role of localized PCSK9 in the pathogenesis of vascular diseases. With this in our consideration, we reviewed PCSK9 physiology with resp...
Zhang, Shi-Zhe Zhu, Xiao-Dong Feng, Long-Hai Li, Xiao-Long Liu, Xue-Feng Sun, Hui-Chuan Tang, Zhao-You
Published in
Experimental Hematology & Oncology
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9), one of the key enzymes in the process of lipid transport, is involved in the disease progression of various types of tumors. This article is to study the role of PCSK9 in the progression of hepatocellular carcinoma (HCC).MethodsImmunohistochemistry was used to assess the expression of...
Hwang, Jin-Taek Choi, Eunji Choi, Hyo-Kyoung Park, Jae-Ho Chung, Min-Yu
Published in
Foods (Basel, Switzerland)
The objective of the present study was to investigate the mechanism by which capsella bursa-pastoris ethanol extract (CBE), containing 17.5 milligrams of icaritin per kilogram of the extract, and icaritin, mediate hypocholesterolemic activity via the low-density lipoprotein receptor (LDLR) and pro-protein convertase subtilisin/kexin type 9 (PCSK9) ...
Rohrbach, Susanne Li, Ling Novoyatleva, Tatyana Niemann, Bernd Knapp, Fabienne Molenda, Nicole Schulz, Rainer
Published in
Frontiers in Physiology
The adipocytokine adiponectin and its structural homologs, the C1q/TNF-related proteins (CTRPs), increase insulin sensitivity, fatty acid oxidation and mitochondrial biogenesis. Adiponectin- and CTRP-induced signal transduction has been described to involve the adiponectin receptors and a number of co-receptors including the Low density lipoprotein...
Ying, Qidi Chan, Dick C. Watts, Gerald F.
Published in
Frontiers in Physiology
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a convertase enzyme mostly produced by the liver. It is a key regulator of LDL metabolism because of its ability to enhance degradation of the LDL receptor. PCSK9 also regulates the metabolism of lipoprotein(a) [Lp(a)] and triglyceride-rich lipoproteins (TRLs). Its key role in modulating athe...
Daou, Anis
Published in
Vaccines
The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this revie...
Kamar, Amina Khalil, Athar Nemer, Georges
Published in
Frontiers in Genetics
Genetically inherited defects in lipoprotein metabolism affect more than 10 million individuals around the globe with preponderance in some parts where consanguinity played a major role in establishing founder mutations. Mutations in four genes have been so far linked to the dominant and recessive form of the disease. Those players encode major pro...
Ibdah, Rasheed K AL-Eitan, Laith N Alrabadi, Nasr N Almasri, Ayah Y Alnaamneh, Adan H Khasawneh, Rame H Alghamdi, Mansour A
Published in
International Journal of General Medicine
Background The main objective of this study is sought to determine the impacts of PCSK9, WDR12, CDKN2A, and CXCL12 polymorphisms on warfarin sensitivity and responsiveness in Jordanian cardiovascular patients during the initiation and stabilization phases of therapy. Methods This study took place at the anticoagulation clinic at Queen Alia Heart In...
Lee, Ga Eun Kim, Jinjoo Lee, Jihei Sara Ko, JaeSang Lee, Eun Jig Yoon, Jin Sook
Published in
Frontiers in Endocrinology
Background The proprotein convertase subtilisin/kexin type 9 (PCSK9) has been implicated in the pathogenesis of inflammatory diseases. We sought to investigate the role of PCSK9 in the pathogenesis of Graves’ orbitopathy (GO) and whether it may be a legitimate target for treatment. Methods The PCSK9 was compared between GO (n=11) and normal subject...
Meshkov, Alexey Ershova, Alexandra Kiseleva, Anna Zotova, Evgenia Sotnikova, Evgeniia Petukhova, Anna Zharikova, Anastasia Malyshev, Pavel Rozhkova, Tatyana Blokhina, Anastasia
...
Published in
Genes
Familial hypercholesterolemia (FH) is a common autosomal codominant disorder, characterized by elevated low-density lipoprotein cholesterol levels causing premature atherosclerotic cardiovascular disease. About 2900 variants of LDLR , APOB , and PCSK9 genes potentially associated with FH have been described earlier. Nevertheless, the genetics of FH...
