Lee, Seo Yun Kim, Jae Jin Miller, Kyle M
Published in
Methods in molecular biology (Clifton, N.J.)
Genome integrity is constantly challenged by various processes including DNA damage, structured DNA, transcription, and DNA-protein crosslinks. During DNA replication, active replication forks that encounter these obstacles can result in their stalling and collapse. Accurate DNA replication requires the ability of forks to navigate these threats, w...
Peng, Xinyue Yu, Susu Lin, Hui Wu, Fan Yang, Jiani Zhou, Cheng Zhang, Luyun Yang, Jianping Zhang, Wenjuan
Published in
International journal of environmental health research
Trichloroacetic acid (TCA) is a common non-volatile by-product of chlorination disinfection for drinking water. It is necessary to know the epigenetic toxicity and mechanisms for establishing safe exposure limit for environmental TCA exposure. This study explored the histone modification variations of TCA-treated human hepatocytes L-02 at different...
Jaiswal, Bharti Agarwal, Akanksha Gupta, Ashish
Published in
Frontiers in Endocrinology
The development and growth of a normal prostate gland, as well as its physiological functions, are regulated by the actions of androgens through androgen receptor (AR) signaling which drives multiple cellular processes including transcription, cellular proliferation, and apoptosis in prostate cells. Post-translational regulation of AR plays a vital...
kim;, ha jung
Neurogenin 1 (Ngn1) belongs to the basic helix–loop–helix (bHLH) transcription factor family and plays important roles in specifying neuronal differentiation. The present study aimed to determine whether forced Ngn1 expression contributes to bone homeostasis. Ngn1 inhibited the p300/CREB-binding protein-associated factor (PCAF)-induced acetylation ...
Carrillo-Sepulveda, Maria Alicia Maddie, Nicole Johnson, Christina Mary Burke, Cameron Lutz, Osina Yakoub, Bamwa Kramer, Benjamin Persand, Dhandevi
Published in
Molecular Medicine
Background Advanced type 2 diabetes mellitus (T2DM) accelerates vascular smooth muscle cell (VSMC) dysfunction which contributes to the development of vasculopathy, associated with the highest degree of morbidity of T2DM. Lysine acetylation, a post-translational modification (PTM), has been associated with metabolic diseases and its complications. ...
Xia, Lu Liu, Yu Zhang, Zhiwei Gong, Yajuan Yu, Tianyi Zhao, Dan Qiu, Wen Wang, Yingwei Zhang, Jing
Published in
Frontiers in Immunology
Interleukin-6 (IL-6) overproduction has been considered to contribute to inflammatory damage of glomerular mesangial cells (GMCs) in human mesangial proliferative glomerulonephritis (MsPGN) and its rat model called Thy-1 nephritis (Thy-1N). However, the regulatory mechanisms of IL-6 expression in GMCs upon sublytic C5b-9 timulation remain poorly un...
Abbas, Minaam
[Restricted] / CRUK, Wellcome Trust, Gates Cambridge, Frank and Elmore Fund
El-Shershaby, Mohamed H Ghiaty, Adel Bayoumi, Ashraf H Al-Karmalawy, Ahmed A Husseiny, Ebtehal M El-Zoghbi, Mona S Abulkhair, Hamada S
Published in
Bioorganic & medicinal chemistry
Inhibition of PCAF bromodomain has been validated as a promising strategy for the treatment of cancer. In this study, we report the bioisosteric modification of the first reported potent PCAF bromodomain inhibitor, L-45 to its triazoloquinazoline bioisosteres. Accordingly, three new series of triazoloquinazoline derivatives were designed, synthesiz...
Wang, Tongxin Chen, Kai Yao, Weilei Zheng, Ruilong He, Qiongyu Xia, Jun Li, Juan Shao, Yafei Zhang, Li Huang, Lu
...
Published in
Journal of hepatology
Lactate has recently been reported to accumulate in the livers of patients progressing from simple steatosis to non-alcoholic steatohepatitis (NASH). However, the underlying mechanism(s) of lactate accumulation and the role of lactate in the progression of non-alcoholic fatty liver disease (NAFLD) are essentially unknown. We compared the acetylome ...
de Jong, Alwin de Jong, Rob C. M. Peters, Erna A. Arens, Ramon Jukema, J. Wouter de Vries, Margreet R. Quax, Paul H. A.
Published in
Frontiers in Cardiovascular Medicine
Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficiency affects atherosclerosis via regulation of regula...
