De Meester, Barbara Madariaga Calderón, Barbara de Vries, Lisanne Pollier, Jacob Goeminne, Geert Van Doorsselaere, Jan Chen, Mingjie Ralph, John Vanholme, Ruben Boerjan, Wout
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Published in
Nature Communications
Plants with reduced amounts of lignin typically suffer from dwarfed growth, which offsets their gain in fermentable sugar yield. Here, the authors show that genome-edited poplar lines with a null and a haploinsufficient allele of CINNAMOYL-COA REDUCTASE2 (CCR2) can be obtained that have a reduced lignin level and normal growth.
Cleeren, E; 73304; Popivanov, ID; Van Paesschen, W; 15539; Janssen, Peter; 14679;
Visual information reaches the amygdala through the various stages of the ventral visual stream. There is, however, evidence that a fast subcortical pathway for the processing of emotional visual input exists. To explore the presence of this pathway in primates, we recorded local field potentials in the amygdala of four rhesus monkeys during a pass...
Carmichael, Catherine L. Wang, Jueqiong Nguyen, Thao Kolawole, Oluseyi Benyoucef, Aissa De Mazière, Charlotte Milne, Anna Samuel, Sona Gillinder, Kevin Robert Hediyeh-zadeh, Soroor
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Modulators of epithelial-to-mesenchymal transition (EMT) have recently emerged as novel players in the field of leukemia biology. The mechanisms by which EMT modulators contribute to leukemia pathogenesis, however, remain to be elucidated. Here we show that overexpression of SNAI1, a key modulator of EMT, is a pathologically relevant event in human...
Pan, Lixia De Smet, Ive
Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs). However, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASEs (MAP4Ks) are hardly explored. Here, we will give a compre...
Kawashima, Masahiro Bensaad, Karim Zois, Christos E. Barberis, Alessandro Bridges, Esther Wigfield, Simon Lagerholm, Christoffer Dmitriev, Ruslan I. Tokiwa, Mariko Toi, Masakazu
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Published in
Cancer & Metabolism
BackgroundHumans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitochondrial inner membrane and converts that energy into heat. It is unclear whether cancer cells can exhibit autonomous thermogenesis. ...
Hillen, Lisa M; Geybels, Milan S; Spassova, Ivelina; Becker, Juergen C; Gambichler, Thilo; Garmyn, Marjan; 3474; zur Hausen, Axel; van den Oord, Joost; 6854; Winnepenninckx, Veronique;
Spitzoid neoplasms are a challenging group of cutaneous melanocytic proliferations. They are characterized by epithelioid and/or spindle-shaped melanocytes and classified as benign Spitz nevi (SN), atypical Spitz tumors (AST), or malignant Spitz tumors (MST). The intermediate AST category represents a diagnostically challenging group since on purel...
Lawlor, Katerina Pérez-Montero, Salvador Lima, Ana Rodríguez, Tristan A
Published in
Seminars in cancer biology
The maintenance of tissue homeostasis and health relies on the efficient removal of damaged or otherwise suboptimal cells. One way this is achieved is through cell competition, a fitness quality control mechanism that eliminates cells that are less fit than their neighbours. Through this process, cell competition has been shown to play diverse role...
Koundouros, N Karali, E Tripp, A Valle, A Inglese, P Perry, NJS Magee, DJ Virmouni, SA Elder, GA Tyson, AL
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Oncogenic transformation is associated with profound changes in cellular metabolism, but whether tracking these can improve disease stratification or influence therapy decision-making is largely unknown. Using the iKnife to sample the aerosol of cauterized specimens, we demonstrate a new mode of real-time diagnosis, coupling metabolic phenotype to ...
Martin-Arroyo, Miguel; del Prado, Anselmo; Chamorro, Raquel; Bilbao, Nerea; 112176; Gonzalez-Rodriguez, David;
In analogy to covalent reactions, the understanding of noncovalent association pathways is fundamental to influence and control any supramolecular process. Following an approach that is reminiscent of covalent methodologies, we study here, for the first time, the mechanism of G-quadruplex formation in organic solvents. Our results support a reactio...
Ploeger, Marten L; Daru, Andrea; 109167; Harvey, Jeremy N; 96198; Hu, Xile;
status: published