Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study.
...Published in Gut
This study provides supportive evidence that oral microbiota may play a role in the aetiology of pancreatic cancer.
Metal or plastic stents for preoperative biliary drainage in resectable pancreatic cancer.
...Published in Gut
Dutch Trial Registry (NTR3142).
Metal or plastic stents for preoperative biliary drainage in resectable pancreatic cancer.
...Published in Gut
Dutch Trial Registry (NTR3142).
Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue.
...Published in Gut
PC-secreted exosomes induce lipolysis in subcutaneous adipose tissue; exosomal AM is a candidate mediator of this effect.
Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue.
...Published in Gut
PC-secreted exosomes induce lipolysis in subcutaneous adipose tissue; exosomal AM is a candidate mediator of this effect.
The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, incl...
Published in Journal of clinical pathology
Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, particularly in other gastrointestinal organs such as ...
MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse mo...
...Published in Gut
Metabolic imaging with hyperpolarised [1-(13)C]pyruvate enables detection and monitoring of the progression of PCa precursor lesions. Translation of this MRI technique to the clinic has the potential to improve the management of patients at high risk of developing PCa.
Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis.
...Published in Gut
According to Nupr1 status, KIC mice develop tumours that phenocopy human classical or QM-PDAC, respectively, and present differential drug sensitivity, thus becoming attractive models for preclinical drug trials.
Exonic variants affecting pre-mRNA splicing add to genetic burden in chronic pancreatitis.
Published in Gut
Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.
Published in Gut
Rare PRSS1 variants found in sporadic chronic pancreatitis do not stimulate autoactivation but may cause increased degradation, impaired secretion or no functional change. Variants with reduced secretion are likely pathogenic due to mutation-induced misfolding and consequent endoplasmic reticulum stress.
