Toward an interdisciplinary approach to assess the adverse health effects of dust-containing polycyclic aromatic hydroca...
Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut–lung microbiome and reduced endoprotectiv...
Published in Frontiers in Immunology
Schistosomiasis-associated Pulmonary Arterial Hypertension (Sch-PAH) is a life-threatening complication of chronic S. mansoni infection that can lead to heart failure and death. During PAH, the expansion of apoptosis-resistant endothelial cells (ECs) has been extensively reported; however, therapeutic approaches to prevent the progression or revers...
Controls on the spatial distribution and temporal variations of PAH in the sediments of the Paris sewerage system.
The urban environment is made up of a complex and changing mosaic of spatial patterns. To what extent the spatial heterogeneities of this mosaic determine the quality of life or social, economic or health inequalities? Within the framework of the ANR EGOUT project (egout.cnrs.fr), we assume that the spatial distribution and temporal evolution of mi...
PAHs remediation from hazardous waste landfill leachate using fenton, photo - fenton and electro - fenton oxidation proc...
Published in Environmental research
Polycyclic aromatic hydrocharbons (PAHs) are a class of highly toxic pollutants that are highly detrimental to the ecosystem. Landfill leechate emanated from municipal solid waste are reported to constitute significant PAHs. In the present investigation, three Fenton proceses, namely conventional Fenton, photo-fenton and electro-fenton methods have...
Contribution of TRPC channels in human and experimental pulmonary arterial hypertension / Contribution of TRPC channels ...
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TRPC3 is increased in human and experimental pulmonary arterial hypertension (PAH). In PAH pulmonary arterial smooth muscle cells, TRPC3 participates in the aberrant store-operated Ca 2+ entry contributing to their pathological cell phenotypes (exacerbated proliferation, enhanced migration, apoptosis resistance, and vasoconstriction). Pharmacologic...
Aryl hydrocarbon receptor-kynurenine axis promotes oncogenic activity in BCP-ALL.
Published in Cell biology and toxicology
B-cell precursor acute lymphoblastic leukemia (BCP-ALL), the most common childhood cancer, originates from lymphoid precursor cells in bone marrow committed to the B-cell lineage. Environmental factors and genetic abnormalities disturb the normal maturation of these precursor cells, promoting the formation of leukemia cells and suppressing normal h...
Chemical compounds associated with increased risk for cancer incidence found in environmental samples obtained from two ...
Published in Frontiers in Materials
Firefighters are exposed to many different biological and chemical contaminants while conducting their work duties, including polyaromatic hydrocarbons or PAHs. PAH compounds are of particular interest in investigations of firefighter health as they have been linked to detrimental health outcomes, including respiratory illnesses and cancers, and ar...
Controls on the spatial distribution and temporal variation of anthropogenic tracers in the sediments of the Paris sewer...
The urban environment is made up of a complex and changing mosaic of spatial patterns. To what extent the spatial heterogeneities of this mosaic determine the quality of life or social, economic or health inequalities? Within the framework of the ANR EGOUT project, we assume that the spatial distribution and temporal evolution of mineral and organi...
Pulmonary hypertension inhaled therapies: An updated review.
Published in The American journal of the medical sciences
Treatments of pulmonary hypertension (PH) continue to evolve with approval of new therapies. The currently FDA approved inhaled PH therapies include inhaled iloprost for group 1 pulmonary arterial hypertension (PAH), inhaled treprostinil solution and treprostinil dry powder inhaler for both group 1 PAH and group 3 PH associated with interstitial lu...
The soluble receptor for advanced glycation end products is potentially predictive of pulmonary arterial hypertension in...
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Published in Frontiers in Immunology
Introduction Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are the leading causes of death in systemic sclerosis (SSc). Until now, no prospective biomarker to predict new onset of SSc-ILD or SSc-PAH in patients with SSc has reached clinical application. In homeostasis, the receptor for advanced glycation end products (RA...
