Published in Cerebellum (London, England)
The classical motor center cerebellum is one of the most consistent structures of abnormality in autism spectrum disorders (ASD), and neuropeptide oxytocin is increasingly explored as a potential pharmacotherapy for ASD. However, whether oxytocin targets the cerebellum for therapeutic effects remains unclear. Here, we report a localization of oxyto...
Arginine-vasopressin (AVP) and oxytocin (OT) are neurohypophysial hormones which share a high sequence and structure homology. These are two cyclic C-terminally amidated nonapeptides with different residues at position 3 and 8. In mammals, AVP and OT exert their multiple biological functions through a specific G protein-coupled receptor family: fou...
The purpose of this narrative review is to use a personal perspective to describe unanticipated and pivotal findings that drew the author into the study oxytocin. Oxytocin was originally described as a female reproductive hormone. However, supporting reproduction is only one of a myriad of functions now attributed to oxytocin. Oxytocin promotes sur...
Published in Biological psychiatry
There is high comorbidity of posttraumatic stress disorder (PTSD) and alcohol use disorder with few effective treatment options. Animal models of PTSD have shown increases in alcohol drinking, but effects of stress history on subsequent vulnerability to alcohol relapse have not been examined. Here we present a mouse model of PTSD involving chronic ...
付記する学位プログラム名: 霊長類学・ワイルドライフサイエンス・リーディング大学院 / 京都大学 / 新制・課程博士 / 博士(理学) / 甲第24828号 / 理博第4977号 / 新制||理||1710(附属図書館) / 京都大学大学院理学研究科生物科学専攻 / (主査)准教授 山本, 真也, 教授 平田, 聡, 教授 村山, 美穂 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM
Published in Reproductive sciences (Thousand Oaks, Calif.)
During pregnancy, the uterus undergoes several modifications under the influence of hormonal and mechanical stimuli. We hypothesize that while most of these modifications are reverted during involution, some of the physiological properties of the uterus are permanently altered. To investigate this hypothesis, we conducted motility experiments to ev...
Alterations in the brain's oxytocinergic system have been suggested to play an important role in the pathophysiology of autism spectrum disorder (ASD), but insights from pediatric populations are sparse. Here, salivary oxytocin was examined in the morning (AM) and afternoon (PM) in school-aged children with (n = 80) and without (n = 40) ASD (boys/g...
L’ocytocine est un neuropeptide hypothalamique impliqué dans le contrôle des émotions. Pour cette raison, je me suis intéressée à l’effet de ce peptide sur l’activité des astrocytes et des neurones de l’amygdale, une structure impliquée dans l’attribution de la valeur émotionnelle. Dans un premier temps, j’ai évalué l’effet à court terme de l’ocyto...
A major issue in neuroscience is the poor translatability of research results from preclinical studies in animals to clinical outcomes. Comparative neuroscience can overcome this barrier by studying multiple species to differentiate between species-specific and general mechanisms of neural circuit functioning. Targeted manipulation of neural circui...
Published in Verhaltenstherapie
Background: Oxytocin might promote favorable psychotherapy outcomes by strengthening the therapeutic alliance. Its involvement in psychotherapeutic processes, especially regarding the therapeutic alliance, needs further investigation. Patients and Methods: Blood oxytocin of 35 male German Armed Forces service members who were seeking treatment for ...
