Jahn, Tabea Clark, Christopher Kerksiek, Anja Lewczuk, Piotr Lütjohann, Dieter Popp, Julius
Published in
The Journal of steroid biochemistry and molecular biology
Altered cholesterol metabolism is associated with increased risk of neurodegeneration and in particular with the development of Alzheimer's disease (AD). Here, we investigate whether non-cholesterol sterols and oxysterols in the central nervous system are associated with (i) the presence of cerebral AD pathology, (ii) distinct aspects of AD patholo...
Koh, Sally Shuxian Ooi, Samantha Chia-Yi Lui, Natalie Man-Yin Qiong, Cao Ho, Leona Ting-Yuke Cheah, Irwin Kee-Mun Halliwell, Barry Herr, Deron R. Ong, Wei-Yi
Published in
Neuromolecular Medicine
Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current study, we elucidated the effect of ET on the hCMEC/D3 human brain endothelial cell line. Endothelial ...
Lepionka, Tomasz Białek, Małgorzata Czauderna, Marian Białek, Agnieszka
Published in
Prostaglandins & other lipid mediators
Despite promising health effects of pomegranate seed oil (PSO) and bitter melon extract (BM) used for centuries as food and traditional medicine, neither mechanism of action nor safety has been fully recognized. This study aimed to evaluate the influence of diet supplementation with PSO and BM on fatty acid, conjugated fatty acid and cholesterol co...
Fidalgo Rodríguez, J L Dynarowicz-Latka, P Miñones Conde, J
Published in
Chemistry and physics of lipids
The Langmuir monolayer technique has long been known for its usefulness to study the interaction between molecules and mimic cellular membranes to understand the mechanism of action of biologically relevant molecules. In this review we summarize the results that provided insight into the potential mechanism for lowering the plasma level of choleste...
Chachaj-Brekiesz, Anna Wnętrzak, Anita Włodarska, Sara Lipiec, Ewelina Dynarowicz-Latka, Patrycja
Published in
The Journal of steroid biochemistry and molecular biology
Systematic studies on the influence of selected ring-oxidized (7α-hydroxycholesterol, 7α-OH; 7β-hydroxycholesterol, 7β-OH; 7-ketocholesterol, 7-K) and chain-oxidized (25-OH) sterols on lipid layer of myelin were performed. Myelin sheath was modeled as five-component Langmuir monolayer (Chol:PE:SM:PS:PC 50:20:12:9:9). Particular oxysterols have been...
Marcello, Alessandro Civra, Andrea Milan Bonotto, Rafaela Nascimento Alves, Lais Rajasekharan, Sreejith Giacobone, Chiara Caccia, Claudio Cavalli, Roberta Adami, Marco Brambilla, Paolo
...
Published in
Redox biology
There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on. Specific side-chain cholesterol oxidation products of the oxysterols family have been shown to inhibit a large variety of both enveloped and non-enveloped human viral pathogens. Here ...
Civra, Andrea Colzani, Mara Cagno, Valeria Francese, Rachele Leoni, Valerio Aldini, Giancarlo Lembo, David Poli, Giuseppe
Published in
Free radical biology & medicine
Physiological cholesterol metabolism implies the generation of a series of oxidized derivatives, whose oxysterols are by far the most investigated ones for their potential multifaceted involvement in human pathophysiology. In this regard, noteworthy is the broad antiviral activity displayed by defined side chain oxysterols, in particular 25-hydroxy...
Ursan, Roman Odnoshivkina, Ulia G Petrov, Alexey M
Published in
Cellular signalling
Oxidation of membrane cholesterol is a hallmark of many pathological conditions, including cardiovascular diseases. Cholesterol could be oxidized in a result of free radical and enzymatic reactions. Here, we studied the effect of cholesterol oxidation by cholesterol oxidase (ChO) on responses to β-AR stimulation in isolated mouse atria. Acute expos...
Targosz-Korecka, Marta Wnętrzak, Anita Chachaj-Brekiesz, Anna Gonet-Surówka, Agnieszka Kubisiak, Agata Filiczkowska, Anna Szymoński, Marek Dynarowicz-Latka, Patrycja
Published in
Biochimica et biophysica acta. Biomembranes
In this paper, systematic studies concerning the influence of selected oxysterols on the structure and fluidity of human erythrocyte membrane modeled as Langmuir monolayers have been performed. Three oxidized cholesterol derivatives, namely 7α-hydroxycholesterol (7α-OH) 7β-hydroxycholesterol (7β-OH) and 7-ketocholesterol (7-K) have been incorporate...
Sottero, Barbara Rossin, Daniela Staurenghi, Erica Gamba, Paola Poli, Giuseppe Testa, Gabriella
Published in
Free radical biology & medicine
High amounts of cholesterol have been definitely associated with the pathogenesis of several diseases, including metabolic and neurodegenerative disorders, cardiovascular diseases, and cancer. In all these pathologies the exacerbation of pro-oxidant and inflammatory responses is a consistent feature. In this scenario, species derived from enzymatic...
