Matalon, Noam; Vergaelen, Elfi; 95675; Shani, Shachar; Dar, Shira; Mekori-Domachevsky, Ehud; Segal-Gavish, Hadar; Hochberg, Yehonatan; Gothelf, Doron; Swillen, Ann; 40725; Taler, Michal;
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BACKGROUND: 22q11.2 Deletion syndrome (22q11.2DS) is the most common microdeletion syndrome in humans. This condition is associated with a wide range of symptoms including immune and neuropsychiatric disorders. Notably, psychotic disorders including schizophrenia have a prevalence of ∼ 30%. A growing body of evidence indicates that neuroinflammatio...
Meng, Qi Liu, Jonathan Shen, Jiaqi Del Rosario, Irish Lakey, Pascale Ritz, Beate Su, Jason Weichenthal, Scott Zhu, Yifang Oroumiyeh, Farzan
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BACKGROUND: Although many studies have linked prenatal exposure to PM2.5 to adverse birth outcomes, little is known about the effects of exposure to specific constituents of PM2.5 or mechanisms that contribute to these outcomes. OBJECTIVES: Our objective was to investigate effects of oxidative potential and PM2.5 metal components from non-exhaust t...
Powell, Jason Powell, Steven Mather, Michael W Beck, Lauren Nelson, Andrew Palmowski, Pawel Porter, Andrew Coxhead, Jonathan Hedley, Ann Scott, Jonathan
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Published in
Thorax
Tracheostomies in children are associated with significant morbidity, poor quality of life, excess healthcare costs and excess mortality. The underlying mechanisms facilitating adverse respiratory outcomes in tracheostomised children are poorly understood. We aimed to characterise airway host defence in tracheostomised children using serial molecul...
Denoncin, Katleen Vertommen, Didier Arts, Isabelle S Goemans, Camille V Rahuel-Clermont, Sophie Messens, Joris Collet, Jean-François
Published in
The Journal of biological chemistry
We report a new function for Escherichia coli DsbC, a protein best known for disulfide bond isomerization in the periplasm. We found that DsbC regulates the redox state of the single cysteine of the L-arabinose-binding protein AraF. This cysteine, which can be oxidized to a sulfenic acid, mediates the formation of a disulfide-linked homodimer under...
Campbell, Steven Utinger, Battist Barth, Alexandre Kalberer, Markus Paulson, Suzanne
The oxidative potential (OP) of particulate matter has been widely suggested as a key metric for describing atmospheric particle toxicity. Secondary organic aerosol (SOA) and redox-active transition metals, such as iron and copper, are key drivers of particle OP. However, their relative contributions to OP, as well as the influence of metal-organic...
Polloni, Lorena Costa, Tássia Rafaella Morais, Lorena Pinheiro Borges, Bruna Cristina Teixeira, Samuel Cota de Melo Fernandes, Thales Alves Correia, Lucas Ian Veloso Bastos, Luciana Machado Gobbi Amorim, Fernanda Quinton, Loïc
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peer reviewed / Cancer cells produce abnormal levels of reactive oxygen species (ROS) that contribute to promote their malignant phenotype. In this framework, we hypothesized that the change in ROS concentration above threshold could impair key events of prostate cancer cells (PC-3) progression. Our results demonstrated that Pollonein-LAAO, a new L...
Sadeghi, Abbas Ghahari, Laya Yousefpour, Mitra Khazaeel, Kaveh Zareian, Parvin
Published in
Journal of chemical neuroanatomy
Inhalation exposure to crude oil vapor (COV) and petroleum products is considered responsible for neurobehavioral toxicity in human and animal models. The antioxidant activity of quercetin (Que) and its derivatives are promising for protecting the hippocampus. This study aimed to evaluate the neuroprotective role of Que against COV-induced behavior...
Salaramoli, Sanaz Amiri, Hamed Joshaghani, Hamid Reza Hosseini, Mahmoud Hashemy, Seyed Isaac
Published in
Metabolic brain disease
Parkinson disease (PD) is a prevalent central nervous system degenerative condition that impacts elderly people. Recent clinical and experimental study findings have established oxidative stress as one of the main pathogeneses of PD. Selenium, a trace metals with antioxidant effects, might reverse the neurobehavioral impairments and oxidative stres...
Salim, Safa Ahmad, Fatima Banu, Ayesha Mohammad, Farhan
Published in
Journal of advanced research
Parkinson's disease (PD) is a disease of ⍺-synuclein aggregation-mediated dopaminergic neuronal loss in the substantia nigra pars compacta, which leads to motor and non-motor symptoms. Through the last two decades of research, there has been growing consensus that inflammation-mediated oxidative stress, mitochondrial dysfunction, and cytokine-induc...
Ghasemi, Parvin Shafiee, Gholamreza Ziamajidi, Nasrin Abbasalipourkabir, Roghayeh
Published in
Biological trace element research
Cu nanoparticles (CuNPs) have various applications in biomedicine, owing to their unique properties. As the effect of CuNPs on the induction of oxidative stress and apoptosis in the human colorectal cancer cell line SW480 has not yet been studied, we investigated the toxicity and mechanism of action of these NPs in SW480 cells. MTT assay was perfor...