Wang, Zhi-shun Zhou, Hai-hong Han, Qi Guo, Yong-lian Li, Zhong-yuan
Published in
Acta Cirúrgica Brasileira
Purpose To investigate the effects of grape seed proanthocyanidin B2 (GSPB2) preconditioning on oxidative stress and apoptosis of renal tubular epithelial cells in mice after renal ischemia-reperfusion (RIR). Methods Forty male ICR mice were randomly divided into 4 groups: Group A: mice were treated with right nephrectomy. Group B: right kidney was...
Islam, Md Aminul Noguchi, Yoko Taniguchi, Shin Yonekura, Shinichi
Published in
Asian-Australasian journal of animal sciences
Cells have increased susceptibility to activation of apoptosis when suffering heat stress (HS). An effective supplementation strategy to mimic heat-induced apoptosis of bovine mammary epithelial cells (MECs) is necessary to maintain optimal milk production. This study aimed to investigate possible protective effects of the anti-apoptotic activity o...
Kim, Kyoung Hwan Park, Jeong-Woong Yang, Young Mok Song, Ki-Duk Cho, Byung-Wook
Published in
Asian-Australasian journal of animal sciences
Stress-induced cytotoxicity caused by xenobiotics and endogenous metabolites induces the production of reactive oxygen species and often results in damage to cellular components such as DNA, proteins, and lipids. The cytochrome P450 (CYP) family of enzymes are most abundant in hepatocytes, where they play key roles in regulating cellular stress res...
Hemşinli, Doğuş Ergene, Saban Karakişi, Sedat Ozan Mercantepe, Tolga Tumkaya, Levent Yilmaz, Adnan Akyilzdiz, Kerimali
Abstract Introduction: Ischemia-associated mortality caused by aortic cross-clamps, as in ruptured abdominal aorta aneurysm surgeries, and reperfusion following their removal represent some of the main emergency conditions in cardiovascular surgery. The purpose of our study was to examine the potential protective effect of tea grape against aortic ...
Ergene, Şaban Hemşinli, Doğuş Karakişi, Sedat Ozan Mercantepe, Tolga Tumkaya, Levent Yilmaz, Adnan
Abstract Objective: To examine the biochemical and histopathological renal effects of ischemia/reperfusion (I/R) injury using a ruptured abdominal aortic aneurysm (RAAA) model in rats and to investigate the potential protective effects of whortleberry (Vaccinium myrtillus). Methods: Thirty-two male Sprague-Dawley rats were randomly assigned into fo...
Parmar, Prashant Perry, Rachel Cesarz, Greta Roberts, Alex Hardman, Houston Caruso, John F.
Published in
Gravitational and Space Research
The deleterious effects of spaceflight encompass numerous physiological effects that undermine long-term goals of manned round-trip missions to Mars. Among the greater losses are to the human musculoskeletal system due to limited mechanical/load-bearing activity. In-flight exercise and nutritional countermeasures seek to reduce physiological losses...
Sun, Yunfeng Pan, Honghua Shen, Shenghui Xia, Zhongni Yu, Zhongmin Li, ChengLe Sun, Pingping Xin, Chuanwei
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Liver fibrosis, defined as the aberrant accumulation of extracellular matrix (ECM) proteins such as collagen in the liver, is a common feature of chronic liver disease, and often culminates in portal hypertension, liver cirrhosis, and hepatic failure. Though therapeutically manageable, fibrosis is not always successfully treated by conve...
Jiang, Tao Yang, Weiwei Zhang, Hongli Song, Zhiqiang Liu, Tianhua Lv, Xiangqi
Published in
Frontiers in Physiology
Lung ischemia-reperfusion (IR) injury remains a significant factor for the early mortality of lung transplantations. Diabetes mellitus (DM) is an independent risk factor for 5-year mortality following lung transplantation. Our previous study showed that DM aggravated lung IR injury and that oxidative stress played a key role in this process. Previo...
Zhang, Min Zhang, Jiangzhao Xiong, Yan Peng, Jiaqing Wu, Xiaoyan
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Diabetic nephropathy (DN) is one of the chronic microvascular complications of diabetes. This study focused on the protective effects of pyrroloquinoline quinone (PQQ) on oxidative stress (OS) in DN. Material/Methods Thirty Sprague Dawley rats were randomly selected for this study; 10 rats were randomly selected as the control group. The...
Zhang, Wenfeng Li, Meng Li, Nana Liu, Zonghua
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background The potential mechanisms underlying premature rupture of membrane (PROM) is still unknown. The aim of this study was to determine the role of Keap-1/Nrf2 signaling pathway activation by oxidative stress in patients with preterm premature rupture of membranes. Material/Methods Placental tissues from preterm premature rupture of membranes ...
