Costa, Bruno Maia Mengal, Vinícius Brasil, Girlandia Alexandre Peluso, Antônio Augusto Treebak, Jonas T Endlich, Patrick Wander de Almeida, Simone Alves de Abreu, Gláucia Rodrigues
Published in
The Journal of nutritional biochemistry
Estrogen deficiency is associated with increased oxidative stress, which can contribute to left ventricular diastolic dysfunction (LVDD). We hypothesized that oral treatment with ellagic acid (EA), a potent and natural antioxidant compound, can improve MI-induced LVDD in ovariectomized rats, by reducing the formation of reactive oxygen species. Ova...
Fakhri, Sajad Sabouri, Shahryar Kiani, Amir Farzaei, Mohammad Hosein Rashidi, Khodabakhsh Mohammadi-Farani, Ahmad Mohammadi-Noori, Ehsan Abbaszadeh, Fatemeh
Published in
The Korean journal of pain
Spinal cord injury (SCI) is one of the most debilitating disorders throughout the world, causing persistent sensory-motor dysfunction, with no effective treatment. Oxidative stress and inflammatory responses play key roles in the secondary phase of SCI. Naringenin (NAR) is a natural flavonoid with known anti-inflammatory and antioxidative propertie...
Hur, Jung Rhee, Chin Kook Jo, Yong Suk
Published in
Tuberculosis and respiratory diseases
We evaluated the effect of particulate matter (PM) and cigarette smoke extract (CSE) on bronchial epithelial cell survival, as well as oxidative stress and autophagy levels. Moreover, we aimed to assess the effect of the antioxidant N-acetylcysteine (NAC) on the adverse effects of PM and CSE exposure. Normal human bronchial epithelial cells (BEAS-2...
Zhang, Amy L Balmes, John R Lutzker, Liza Mann, Jennifer K Margolis, Helene G Tyner, Tim Holland, Nina Noth, Elizabeth M Lurmann, Fred Hammond, S Katharine
...
Published in
Journal of exposure science & environmental epidemiology
Previous research has revealed links between air pollution exposure and metabolic syndrome in adults; however, these associations are less explored in children. This study aims to investigate the association between traffic-related air pollutants (TRAP) and biomarkers of metabolic dysregulation, oxidative stress, and lung epithelial damage in child...
Wang, Jiyuan Chen, Yu
Published in
Acta Cirúrgica Brasileira
Purpose: To explore the mechanism and investigate the protective effect of hydroxysafflor yellow A (HSYA) on renal oxidative stress, which cyclosporine A (CsA) induces. Methods: HK-2 cells were treated with CsA to get CsA-induced oxidative stress. The effects on oxidative stress and apoptosis of HK-2 cells were detected. The contents of SOD, MDA, G...
Liu, Li-Li Yang, Jing Ye, Zhong-Lv Tian, Chuan Huang, Xiu-Lan Zhang, Hui-Qin Mo, Xiao-Huan
Published in
Frontiers in Environmental Science
Objective: This study aims to explore the toxic effect of PM2.5 on the hematopoietic microenvironment of the bone marrow, and investigate the effect of PM2.5 on oxidative stress injury, the secretion of inflammatory cytokines and the expression of NF-κB p65 and C x 43 in the bone marrow of mice. Methods: A total of 615 mice were treated with normal...
Nunes, Carolina; Singh, Pranika; Mazidi, Zahra; Murphy, Cormac; Bourguignon, Aurore; Wellens, Sara; Chandrasekaran, Vidya; Ghosh, Sreya; 115804; Zana, Melinda; Pamies, David;
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Most OECD guidelines for chemical risk assessment include tests performed on animals, raising financial, ethical and scientific concerns. Thus, the development of human-based models for toxicity testing is highly encouraged. Here, we propose an in vitro multi-organ strategy to assess the toxicity of chemicals. Human induced pluripotent stem cells (...
Sun, Chuang Wang, Tingting Wang, Changying Zhu, Zhenyin Wang, Xiaoni Xu, Jia An, Huixian
Published in
Brazilian journal of cardiovascular surgery
The objective of this study is to investigate the protective effect of kaempferol against ischemia/reperfusion (IR) injury and the underlying molecular mechanisms. H9C2 cells were pretreated with kaempferol for 24 hours and further insulted with IR injury. Cell vitality, reactive oxygen species (ROS) level, glutathione (GSH) level, nicotinamide ade...
Dong, Xiang Li, Jia-Jia Ma, Na Liu, Ai-Zhong Liu, Jiang-Wei
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Isorhamnetin is a natural flavonoid compound with anti-inflammatory and antioxidant properties. However, its roles in alleviating lung injury associated with heatstroke remain unclear. Therefore, this study aimed to evaluate the protective effects of different isorhamnetin doses on lung injury in heatstroke rat models exposed to a dry-he...
Demets, Robbe; 117478; Bonneux, Lore; Dejonghe, Céline; Gheysen, Lore; 92774; Van Loey, Ann; 14117; Foubert, Imogen; 55517;
Several species of microalgae are promising as an alternative source of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA). Photoautotrophic species show the greatest potential, since incorporating them into food products leads to oxidatively stable products; however, the presence of photosensitizers could reduce the shelf-life due to the...
