Stasenko, Marina Smith, Evan Yeku, Oladapo Park, Kay J. Laster, Ian Lee, Kwangkook Walderich, Sven Spriggs, Elizabeth Rueda, Bo Weigelt, Britta
...
Published in
Scientific Reports
The lectin, galectin-3 (Gal3), has been implicated in a variety of inflammatory and oncogenic processes, including tumor growth, invasion, and metastasis. The interactions of Gal3 and MUC16 represent a potential targetable pathway for the treatment of MUC16-expressing malignancies. We found that the silencing of Gal3 in MUC16-expressing breast and ...
Lu, Huan Zheng, Guanlin Gao, Xiang Chen, Chanjuan Zhou, Min Zhang, Longxin
Published in
Journal of Ovarian Research
BackgroundPropofol is a kind of common intravenous anaesthetic agent that plays an anti-tumor role in a variety of cancers, including ovarian cancer. However, the working mechanism of Propofol in ovarian cancer needs further exploration.MethodsThe viability and metastasis of ovarian cancer cells were assessed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-dip...
Zuo, Li Li, Xiaoli Tan, Yue Zhu, Hailong Xiao, Mi
Published in
Journal of Ovarian Research
ObjectiveMicroRNAs (miRNAs) play a vital role in the development of ovarian cancer (OC). The aim of this study to investigate the prognostic value and potential signaling pathways of hsa-miR-9-5p (miR-9) in OC through literature review and bioinformatics methods.MethodsThe expression of miR-9 in OC was assessed using the public datasets from the Ge...
Macciò, Antonio Oppi, Sara Madeddu, Clelia
Published in
Journal of Ovarian Research
Improving early diagnosis along with timely and effective treatment of COVID-19 are urgently needed. However, at present, the mechanisms underlying disease spread and development, defined prognosis, and immune status of patients with COVID-19 remain to be determined. Patients with severe disease state exhibit a hyperinflammatory response associated...
Bishnu, Aniketh Phadte, Pratham Dhadve, Ajit Sakpal, Asmita Rekhi, Bharat Ray, Pritha
Published in
Cell Death & Disease
Alterations in key kinases and signaling pathways can fine-tune autophagic flux to promote the development of chemoresistance. Despite empirical evidences of strong association between enhanced autophagic flux with acquired chemoresistance, it is still not understood whether an ongoing autophagic flux is required for both initiation, as well as mai...
He, Chaofan Huang, Fuxin Zhang, Kejia Wei, Jun Hu, Ke Liang, Meng
Published in
Journal of Ovarian Research
BackgroundOvarian cancer (OC) is one of the most common gynecological malignant tumors worldwide, with high mortality and a poor prognosis. As the early symptoms of malignant ovarian tumors are not obvious, the cause of the disease is still unclear, and the patients’ postoperative quality of life of decreases. Therefore, early diagnosis is a proble...
Gorodnova, Tatiana V. Sokolenko, Anna P. Kotiv, Khristina B. Sokolova, Tatiana N. Ivantsov, Alexandr O. Guseynov, Konstantin D. Nekrasova, Ekaterina A. Smirnova, Olga A. Berlev, Igor V. Imyanitov, Evgeny N.
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Published in
Hereditary Cancer in Clinical Practice
BackgroundCisplatin, mitomycin C and anthracyclines demonstrate high activity in BRCA1-deficient tumors. This study aimed to evaluate the efficacy of the triplet combination of these drugs in BRCA1-driven high-grade serous ovarian carcinomas (HGSOCs).MethodsTen HGSOC patients with germ-line BRCA1 mutation received neoadjuvant chemotherapy (NACT) co...
Mitamura, Takashi Sekine, Masayuki Arai, Masami Shibata, Yuka Kato, Momoko Yokoyama, Shiro Yamashita, Hiroko Watari, Hidemichi Yabe, Ichiro Nomura, Hiroyuki
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Published in
World Journal of Surgical Oncology
Disease sites of female genital tract cancers of BRCA1/2-associated hereditary breast and ovarian cancer (HBOC) are less understood than non-hereditary cancers. We aimed to elucidate the disease site distribution of genital cancers in women with the germline BRCA1 and BRCA2 pathogenic variants (BRCA1+ and BRCA2+) of HBOC. For the primary disease si...
Essel, KG Behbakht, K Lai, T Hand, L Evans, E Dvorak, J Ding, K Konecny, G Moore, KN
The objective of this study was to describe the treatment experience of patients with recurrent epithelial ovarian cancer who are retreated with an inhibitor of poly(ADP-ribose)-polymerase (PARPi). We conducted a multi-institutional, retrospective review of ovarian cancer patients who received ≥2 lines of therapy containing a PARPi. Demographic, cl...
Satyavarapu, Eswara Murali Nath, Shalini Mandal, Chitra
Published in
Cell Death Discovery
Increased sialylation is one of the hallmarks of ovarian cancer (OC) but its relation with programmed cell death is not known. Here we explored the molecular interplay between autophagy, apoptosis/anoikis, and aberrant-expression of the PI3K-Akt/mTOR pathway in the context of sialidase. OC is accompanied by low expression of cytosolic sialidase (Ne...
