Liu, Yang Xu, Yangchun Ding, Lei Yu, Lili Zhang, Butian Wei, Dan
Published in
Cancer Cell International
BackgroundOvarian cancer (OC) is a common female reproductive malignancy with a high mortality rate. Although LAMA4 was observed to be downregulated in OC cells, its mechanism in regulating OC metastasis is still unknown. This study aimed to investigate the effect of LAMA4 and its mechanism on OC.MethodsTo achieve this aim, a microarray analysis wa...
Norouzi-Barough, Leyla Asgari Khosro Shahi, Amir Mohebzadeh, Farnoosh Masoumi, Ladan Haddadi, Mohammad Reza Shirian, Sadegh
Published in
Cancer Cell International
Exosomes (EXs) are small extracellular vesicles, a size range of 40-100 nm in diameter, actively secreted by most eukaryotic cells into surrounding body fluids like blood, saliva, urine, bile, breast milk and etc. These endosomal-derived vesicles mediate cell–cell communication between various cell populations through transmitting different signali...
Henriksen, Jon Røikjær Nederby, Line Donskov, Frede Waldstrøm, Marianne Adimi, Parvin Jakobsen, Anders Steffensen, Karina Dahl
Published in
Journal of Ovarian Research
PurposeBiomarkers are needed to guide treatment decisions in recurrent ovarian cancer, as a high proportion of patients do not benefit from treatments. Data on immune subsets in patients receiving chemotherapy are scarce. We investigated the impact of T cells, B cells, neutrophils and the neutrophil-lymphocyte ratio (NLR) in ovarian cancer patients...
Kowalchuk, Roman O. Waters, Michael R. Richardson, K. Martin Spencer, Kelly Larner, James M. Irvin, William P. Kersh, Charles R.
Published in
Radiation Oncology
BackgroundThis study evaluates the outcomes and toxicity of stereotactic body radiation therapy (SBRT) in ovarian cancer.MethodsThis retrospective analysis considered all patients treated with SBRT from 2009 to 2018 with a primary ovarian tumor. Follow-up included PET-CT and CT scans at 2–3 month intervals. Statistical analysis primarily consisted ...
Wang, Yiru Yan, Ying Yang, Mengying Yang, Zhijun
Published in
3 Biotech
This study aimed to explore the expressions of signal transducer and activator of transcription 3 (STAT3) and a gene associated with retinoid-interferon induced mortality (Grim19) in epithelial ovarian cancer (EOC), and to determine their correlations with tumor progression and metastasis as well as the related mechanism. Ovarian tissue specimens r...
Segura-Sampedro, Juan José Morales-Soriano, Rafael Arjona-Sánchez, Álvaro Cascales-Campos, Pedro
Published in
World Journal of Surgical Oncology
Recent evidence suggested that secondary surgical cytoreduction followed by chemotherapy does not result in longer overall survival in patients with platinum-sensitive recurrent ovarian cancer. This statement is based on a phase III multicenter, randomized clinical trial that lacks a description of the surgical protocol, the surgical technique, and...
Mehta, Ritu Yadav, Rashmi
Published in
Indian Journal of Gynecologic Oncology
AimTo compare the accuracy of Frozen section with CA125, T.Inhibin, and AdenexaIOTA score.DesignCross-sectional study.Materials and MethodsThis study was conducted over a period of 25 months in a tertiary care hospital. Seventy-one patients with diagnosed ovarian mass were enrolled. Presurgical measurement of Ca125 and T.Inhibin serum markers were ...
Lin, Qingqing Liu, Wenchao Xu, Song Li, Juan Tong, Jinyi
Published in
Journal of Ovarian Research
BackgroundThe therapeutic value of systematic lymphadenectomy during debulking surgery for ovarian cancer remains controversial. We conduct this meta-analysis to evaluate the significance of systematic lymphadenectomy in patients treated with optimal cytoreduction for ovarian cancer.MethodThe PubMed, Medline, Embase, Cochrane Library and Web of Sci...
Wang, Jiaying Zhu, Miaohua Zhou, Xiaoming Wang, Tingting Xi, Yanni Jing, Zhang Xi, Wenjin
Published in
Journal of Biosciences
Natural killer (NK) cells have pivotal role in immunotherapy of human ovarian cancer (OC). Although microRNAs (miRNAs) participate in dysfunction of NK cells, how and whether miR-140-3p regulates cytotoxicity of NK cells in OC are uncertain. miR-140-3p and mitogen activated protein kinase 1 (MAPK1) abundances were examined via quantitative real-tim...
Zhang, Qi Yan, Guifang Lei, Juan Chen, Yu Wang, Ting Gong, Juan Zhou, Yong Zhao, Huakan Chen, Hao Zhou, Yu
...
Published in
Molecular Medicine
BackgroundOvarian cancer is the most lethal gynecologic cancer. Chemoresistance, especially platinum-resistance, is closely related to metastasis of ovarian cancer, however, the molecular basis by which links chemoresistance and metastasis remains vague. Disordered arachidonic acid (AA) metabolism has been shown to play an important role in the adv...
