Bommer, Claudine Lupatsch, Judith Bürki, Nicole Schwenkglenks, Matthias
Published in
The European journal of health economics : HEPAC : health economics in prevention and care
We aimed to identify the most cost-effective of all prophylactic measures available in Switzerland for women not yet affected by breast and ovarian cancer who tested positive for a BRCA1/2 mutation. Prophylactic bilateral mastectomy (PBM), salpingo-oophorectomy (PBSO), combined PBM&PBSO and chemoprevention (CP) initiated at age 40 years were compar...
Beg, Anam Parveen, Rafat Fouad, Hassan Yahia, M. E. Hassanein, Azza S.
Published in
Journal of Ovarian Research
Background Among many gynecological malignancies ovarian cancer is the most prominent and leading cause of female mortality worldwide. Despite extensive research, the underlying cause of disease progression and pathology is still unknown. In the progression of ovarian cancer different non-coding RNAs have been recognized as important regulators. Th...
Li, Fangfang Zhao, Chen Diao, Yuchao Wang, Zixiang Peng, Jiali Yang, Ning Qiu, Chunping Kong, Beihua Li, Yingwei
Published in
Cell Death & Disease
The latest research shows that RNA-binding proteins (RBPs) could serve as novel potential targets for cancer therapy. We used bioinformatics analysis to screen and identify the key RBPs in ovarian cancer, from which we found that Mex-3 RNA Binding Family Member A (MEX3A) was intimately associated with the clinical prognosis of ovarian cancer. Never...
Zhu, Songling Bao, Hongxia Zhang, Meng-Chun Liu, Huidi Wang, Yao Lin, Caiji Zhao, Xingjuan Liu, Shu-Lin
Published in
BMC Cancer
Background Ovarian cancer (OC) is among the deadliest malignancies in women and the lack of appropriate markers for early diagnosis leads to poor prognosis in most cases. Previous studies have shown that KAZN is involved in multiple biological processes during development, such as cell proliferation, differentiation, and apoptosis, so defects or ab...
Sánchez-Prieto, Manuel Sánchez-Borrego, Rafael Lubián-López, Daniel Maria Pérez-López, Faustino R.
Published in
Gynecologic Oncology Reports
Ovarian cancer is one of the most common gynecologic cancers and has the highest mortality rate. The risk/protective factors of ovarian cancer suggest that its etiology is multifactorial. Several factors are involved in age-related increases in carcinogenesis, including the accumulation of senescent cells, inflammaging (a chronic inflammatory state...
Rempel, E. Kluck, K. Beck, S. Ourailidis, I. Kazdal, D. Neumann, O. Volckmar, A. L. Kirchner, M. Goldschmid, H. Pfarr, N.
...
Published in
NPJ Precision Oncology
Homologous repair deficiency (HRD) is present in many cancer types at variable prevalence and can indicate response to platinum-based chemotherapy and PARP inhibition. We developed a tumor classification system based on the loss of function of genes in the homologous recombination repair (HRR) pathway. To this end, somatic and germline alterations ...
Zhang, Zaixin Xue, Si-tu Gao, Yan Li, Yingwei Zhou, Ziying Wang, Jing Li, Zhuorong Liu, Zhaojian
Published in
Cell Death Discovery
FOXM1 is a potent oncogenic transcription factor essential for cancer initiation, progression, and drug resistance. FOXM1 regulatory network is a major predictor of adverse outcomes in various human cancers. Inhibition of FOXM1 transcription factor function is a potential strategy in cancer treatment. In this study, we performed structure-based in ...
Lu, Huaiwu Liu, Yunyun Wang, Jingyu Fu, Shaliu Wang, Lingping Huang, Chunxian Li, Jing Xie, Lingling Wang, Dongyan Li, Dan
...
Published in
Clinical Epigenetics
Background Ovarian cancer (OC) is a highly lethal gynecologic cancer, and it is hard to diagnose at an early stage. Clinically, there are no ovarian cancer-specific markers for early detection. Here, we demonstrate the use of cell-free DNA (cfDNA) methylomes to detect ovarian cancer, especially the early-stage OC. Experimental design Plasma from 74...
Song, Yang Qu, Hui
Published in
BMC Cancer
Background Long non-coding RNAs (lncRNAs) play an important role in angiogenesis, immune response, inflammatory response and tumor development and metastasis. m6 A (N6—methyladenosine) is one of the most common RNA modifications in eukaryotes. The aim of our research was to investigate the potential prognostic value of m6A-related lncRNAs in ovaria...
Hassan, Ayon A. Artemenko, Margarita Tang, Maggie K. S. Shi, Zeyu Chen, Lin-Yu Lai, Hung-Cheng Yang, Zhenyu Shum, Ho-Cheung Wong, Alice S. T.
Published in
Cell Death & Disease
Overcoming drug resistance is an inevitable challenge to the success of cancer treatment. Recently, in ovarian cancer, a highly chemoresistant tumor, we demonstrated an important role of shear stress in stem-like phenotype and chemoresistance using a three-dimensional microfluidic device, which most closely mimics tumor behavior. Here, we examined ...
