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Sucur, Alan Jajic, Zrinka Artukovic, Marinko Matijasevic, Marina Ikic Anic, Branimir Flegar, Darja Markotic, Antonio Kelava, Tomislav Ivcevic, Sanja Kovacic, Natasa
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Published in
Arthritis Research & Therapy
BackgroundThe peripheral blood (PB) monocyte pool contains osteoclast progenitors (OCPs), which contribute to osteoresorption in inflammatory arthritides and are influenced by the cytokine and chemokine milieu. We aimed to define the importance of chemokine signals for migration and activation of OCPs in rheumatoid arthritis (RA) and psoriatic arth...
Wang, Chung-Lin Tsai, Mei-Ling Wu, Sheng-Nan
Published in
Cellular Physiology and Biochemistry
Background/Aims: Mitoxanthrone (MX) is an anthracenedione antineoplastic agent. Whether this drug and other related compounds have any effects on ion currents in osteoclasts remains largely unclear. Methods: In this study, the effects of MX and other related compounds on inwardly rectifying K+ current (IK(IR)) were investigated in RAW 264.7 osteocl...