Palada, Vinko Ahmed, Aisha Siddiqah Freyhult, Eva Hugo, Anders Kultima, Kim Svensson, Camilla I Kosek, Eva
Published in
Journal of neuroimmunology
Neuroinflammation and periphery-to-CNS neuroimmune cross-talk in patients with painful knee osteoarthritis (OA) are poorly understood. We utilized proximity extension assay to measure the level of 91 inflammatory proteins in CSF and serum from OA patients and controls. The patients had elevated levels of 48 proteins in CSF indicating neuroinflammat...
Melnik, Svitlana Gabler, Jessica Dreher, Simon I. Hecht, Nicole Hofmann, Nina Großner, Tobias Richter, Wiltrud
Published in
Stem Cell Research & Therapy
BackgroundHuman mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplantation, known as hypertrophic degeneration, remains the major obstacle limiting application of MSC in cartilage tissue regeneration...
Zhao, Guanglei Liu, Changquan Chen, Kangming Chen, Feiyan Lyu, Jinyang Chen, Jie Shi, Jingsheng Huang, Gangyong Wei, Yibing Wang, Siqun
...
Published in
Journal of Orthopaedic Surgery and Research
BackgroundThe current research used a new index—adipose to muscle area ratio (AMR)—to measure fatness compared with body mass index (BMI) in elderly osteoarthritis (OA) patients following total knee arthroplasty. Our study aimed to test the relationship between the two indexes (AMR and BMI) and to examine whether AMR was a predictive factor of pati...
Huang, Cibo Zhang, Zhiyi Chen, Yaolong Zhang, Yue Xing, Dan Zhao, Like Lin, Jianhao Mei, Yifang Lin, Hsiao-Yi Zheng, Yi
...
Published in
Annals of Translational Medicine
Background The classification criteria of osteoarthritis (OA) is lack of the support of relevant research evidence and there is no standardized protocol for detailed steps of the development or clinical verification of classification criteria has yet been established. This study aims to describe the development process of the Categorization of Oste...
Sayre, Eric C. Esdaile, John M. Kopec, Jacek A. Singer, Joel Wong, Hubert Thorne, Anona Guermazi, Ali Nicolaou, Savvas Cibere, Jolanda
Published in
BMC Musculoskeletal Disorders
BackgroundTo evaluate whether knee osteoarthritis (OA) manifestations predict depression and anxiety using cross-sectional and longitudinal prediction models.MethodsA population-based cohort (n = 122) with knee pain, aged 40–79, was evaluated at baseline, 3 and 7 years. Baseline predictors were: age decade; sex; BMI ≥ 25; physical exam knee effusio...
Liu, Li Wang, Sen Wen, Yan Li, Ping Cheng, Shiqiang Ma, Mei Zhang, Lu Cheng, Bolun Qi, Xin Liang, Chujun
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Published in
Annals of Translational Medicine
Background Osteoarthritis (OA) is a multifactorial complex disease. The impact of plasma proteins on OA remains elusive now. Methods The UK Biobank genome-wide association study data of OA was used here. Genome-wide SNP genotyping was performed using the Affymetrix UK BiLEVE Axiom or UK Biobank Axiom array. Equally, the GWAS summary data of 3,622 p...
Guo, Yusong Tian, Lijun Du, Xiqiao Deng, Zhigang
Published in
Journal of bone and mineral metabolism
Estrogen receptor α (ERα) plays important roles in the etiology of osteoarthritis (OA), in which cartilage degradation and cellular inflammation are involved. MiR-203 is reported to direct target ERα, but its roles in chondrocytes remain uncovered. In this study, ELISA showed that the level of estrogen hormone in the serum of postmenopausal OA pati...
Bonnefoy-Mazure, Alice Favre, Thibault Praplan, Guillaume Armand, Stéphane Sagawa Junior, Yoshimasa Hannouche, Didier Turcot, Katia Lübbeke, Anne Miozzari, Hermes H
Published in
Gait & posture
The purpose of this prospective study was to understand the relation between gait outcomes and patient satisfaction one year after total knee arthroplasty (TKA). Seventy-nine patients were evaluated before and one year after TKA using clinical gait analysis. Specific gait outcomes were analyzed: gait speed, stance phase, range of motion (ROM) knee ...
Jiang, Ai Gao, Shan Zhao, Zhenda Tan, Qizhao Sun, Shang Song, Chunli Leng, Huijie
Published in
Annals of Translational Medicine
Background Osteoarthritis (OA) is prevalent in postmenopausal women. Subchondral bone in ovariectomized (OVX) rats might play a more important role in cartilage degeneration compared with other types of OA. How subchondral osteoblast changes in OVX rats is still unclear. Understanding of osteoblast changes obtained from OVX subchondral bone might b...
Zhou, Yu Wang, Zhicong Chen, Xi Zhang, Jianjun Yang, Ling Liu, Shuping Liu, Yuehong
Published in
BMC Medical Genetics
BackgroundOsteoarthritis (OA) is the most common form of arthritis and a leading cause of disability. This study attempted to investigate the key mRNAs and miRNAs related to OA.Patients and methodsFrom April 17th, 2018 to May 17th, 2018, five patients with OA and three normal controls were enrolled in this present study. To identify the differentia...