Rai, Deepak Singh, Jyotsana Somashekharappa, Thimmappa Singh, Ajit
Published in
SICOT-J
Objective: PRP is produced by centrifugation of whole blood containing highly concentrated platelets, associated growth factors, and other bioactive agents which has been shown to provide some symptomatic relief in early knee osteoarthritis (OA). The principal objective of our study was to evaluate the effectiveness and safety of standardized intra...
Lane, Nancy E Ivanova, Jasmina Emir, Birol Mobasheri, Ali Jensen, Morten Georg
PurposeOsteoarthritis (OA) is a frequently occurring, chronic condition; however, few studies describe the clinical characteristics of individuals with OA and the treatments they use to manage their symptoms. We conducted a study to characterize the OA population in the US and describe the nonsurgical management used by this population based on con...
Fernández-Martín, Silvia López-Peña, Mónica Muñoz, Fernando Permuy, María González-Cantalapiedra, Antonio
Published in
Arthritis Research & Therapy
Bisphosphonates have been proposed as possible disease-modifying drugs in osteoarthritis. However, the evidence of their efficacy is poor and their outcomes presented a great heterogeneity. Therefore, the aim of this study is to systematically review the main effects of bisphosphonate use on synovial joint tissues and biochemical markers in preclin...
Wu, Wen-Tien Chen, Yi-Ru Lu, Dai-Hua Senatov, Fedor Svyatoslavovich Yang, Kai-Chiang Wang, Chen-Chie
Published in
Journal of Orthopaedic Surgery and Research
Background Silymarin (SMN), a polyphenolic flavonoid, is involved in multiple bioactive functions including anti-inflammation. Pretreatment with SMN demonstrated chondroprotection against tumour necrosis factor-alpha (TNF-α) stimulation in a chondrocyte cell line. However, pre- and posttreatment with phytochemicals have varying effects on osteoarth...
Liu, Ming Xie, Zikun Sun, Guang Chen, Liujun Qi, Dake Zhang, Hongwei Xiong, Jieying Furey, Andrew Rahman, Proton Lei, Guanghua
...
Published in
Arthritis Research & Therapy
Background Osteoarthritis (OA) is the most prevalent form of arthritis and the major cause of disability and overall diminution of quality of life in the elderly population. Currently there is no cure for OA, partly due to the large gaps in our understanding of its underlying molecular and cellular mechanisms. Macrophage migration inhibitory factor...
Saruga, Tatsuro Sasaki, Eiji Inoue, Ryo Chiba, Daisuke Ota, Seiya Iwasaki, Hiroki Uesato, Ryoko Nakaji, Shigeyuki Ishibashi, Yasuyuki
Published in
Scientific Reports
The factors predicting hand osteoarthritis (HOA) in patients remain unknown. We aimed to investigate the usefulness of serum hyaluronic acid (sHA) levels in predicting HOA progression from a 6-year longitudinal epidemiological study. A total of 417 participants in the Iwaki cohort were followed-up over 6 years. Hand and knee radiographs taken at ba...
Wang, Zhiwei Wen, Liang Zhang, Liang Ma, Desi Dong, Xiang Qu, Tiebing
Published in
BMC Musculoskeletal Disorders
Background A mismatch between the femoral component and trochlear resection surface is observed in kinematically aligned total knee arthroplasty (KA-TKA) when conventional prostheses are employed. This mismatch is mainly manifested in the undercoverage of the lateral trochlear resection surface. The aim of the present study was to assess the relati...
Baghban, Farnaz Hosseinzadeh, Mahdieh Mozaffari-Khosravi, Hassan Dehghan, Ali Fallahzadeh, Hossein
Published in
BMC Musculoskeletal Disorders
Backgrounds L-carnitine decreases oxidation and inflammation by reducing the fatty acid in plasma and using oxygen in ATP synthesis. As such, knee osteoarthritis (KOA) can be improved by reducing apoptotic chondrocytes. This study was designed to compare the effect of L-carnitine supplementation and low-calorie diet on improving KOA among obese wom...
Koo, Hyeon-Kyoung Song, Pamela Lee, Joo-Hyun
Published in
BMC Pulmonary Medicine
Background Asthma and osteoarthritis (OA) are medical conditions that inhibit physical activity and adversely affect quality of life. Despite the high prevalence, there are limited studies focusing on the comorbid condition and association between asthma and OA. The aim of this study was to assess the prevalence of OA co-occurring with asthma and t...
Zhang, Ke Li, Zhuoying Lu, Yunyang Xiang, Linyi Sun, Jiadong Zhang, Hong
Published in
Journal of Orthopaedic Surgery and Research
Background The Wnt planar cell polarity (PCP) pathway is implicated in osteoarthritis (OA) both in animals and in humans. Van Gogh-like 2 (Vangl2) is a key PCP protein that is required for the orientation and alignment of chondrocytes in the growth plate. However, its functional roles in OA still remain undefined. Here, we explored the effects of V...