Kung, Louise H. W. Mullan, Lorna Soul, Jamie Wang, Ping Mori, Kazutoshi Bateman, John F. Briggs, Michael D. Boot-Handford, Raymond P.
Published in
Arthritis Research & Therapy
BackgroundOsteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sensors, one of which is activating transcription factor 6 (ATF6). The purpose of this study is to determine whether increased ER stre...
Zu, Yan Mu, Yue Li, Qiang Zhang, Shu-Ting Yan, Hong-Juan
Published in
Journal of Orthopaedic Surgery and Research
BackgroundOsteoarthritis (OA) is the common chronic degenerative joint bone disease that is mainly featured by joint stiffness and cartilage degradation. Icariin (ICA), an extract from Epimedium, has been preliminarily proven to show anti-osteoporotic and anti-inflammatory effects in OA. However, the underlying mechanisms of ICA on chondrocytes nee...
Orhurhu, Vwaire Schwartz, Ruben Potts, Jacob Peck, Jacqueline Urits, Ivan Orhurhu, Mariam Salisu Odonkor, Charles Viswanath, Omar Kaye, Alan Gill, Jatinder
...
Published in
Current Pain and Headache Reports
Purpose of ReviewChronic knee pain remains a debilitating condition that remains difficult to manage. The purpose of this review, therefore, is to summarize current understanding of alpha-2-microglobulin in the treatment of osteoarthritic knee pain. Furthermore, we investigate its role in the anti-inflammatory properties of platelet-rich plasma (PR...
Nakamura, Suguru Ikebuchi, Mitsuhiko Saeki, Souichi Furukawa, Daisuke Orita, Kumi Niimi, Nobuo Tsukahara, Yoshito Nakamura, Hiroaki
Published in
BMC Musculoskeletal Disorders
BackgroundBiomechanical changes in articular cartilage are associated with the onset of osteoarthritis. We developed an optical coherence tomography-based strain rate tomography method: stress relaxation optical coherence straingraphy (SR-OCSA). The purpose of this study was to establish an approach for measuring mechanical properties of articular ...
Seifeldein, Gehan S. Haseib, Abolhasan Hassan, Hosam A. Ahmed, Ghada
Published in
Egyptian Journal of Radiology and Nuclear Medicine
BackgroundKnee osteoarthritis (KOA) is the most common cause of a painful joint, and it is associated with significant health economic consequences. About literature, KOA is usually diagnosed according to changes seen on conventional radiography, but the radiographic features of OA do not correlate with its symptoms. Nowadays, ultrasonography is be...
Harato, Kengo Yagi, Mitsuru Fujita, Nobuyuki Kobayashi, Shu Ohya, Akihito Kaneda, Kazuya Iwama, Yu Nakamura, Masaya Matsumoto, Morio
Published in
BMC Musculoskeletal Disorders
BackgroundObesity is an important factor affecting incidence and development of musculoskeletal degenerative changes. In addition, obese patients are considered less favorable surgical candidates for decompression surgery in degenerative lumbar spinal canal stenosis and lower limb arthroplasty. The purpose was to assess disease characteristics of l...
Wang, Kai Xing, Dan Dong, Shengjie Lin, Jianhao
Published in
BMC Musculoskeletal Disorders
BackgroundOsteoarthritis (OA) is the most common joint disorder among elderly individuals. Nonsurgical treatment plays an important role in treating knee OA. The aim of the present study was to investigate the trends and research status about nonsurgical treatment of knee OA.MethodsPublications about the nonsurgical treatment of knee OA from 1994 t...
Bihlet, Asger Reinstrup Byrjalsen, Inger Bay-Jensen, Anne-Christine Andersen, Jeppe Ragnar Christiansen, Claus Riis, Bente Juel Karsdal, Morten A.
Published in
Arthritis Research & Therapy
BackgroundExcessive cartilage degradation is a known characteristic of osteoarthritis (OA). Biochemical markers, such as uCTX-II, have been shown to be associated with disease severity, yet the tissue origin of CTX-II has been disputed. This analysis investigates the association between OA knee joints at different radiographic stages and pain categ...
Pelle, Tim Bevers, Karen van der Palen, Job van den Hoogen, Frank H. J. van den Ende, Cornelia H. M.
Published in
BMC Musculoskeletal Disorders
BackgroundThis paper describes (the development of) an eHealth tool (dr. Bart app) to enhance self-management and to optimize non-surgical health care utilization in patients with knee and/or hip osteoarthritis (OA) and presents a study aiming 1) to study the effectiveness of the dr. Bart app on health care use 2) to explore differences in use, usa...
de Salazar Alcalá, Andrea García Gioda, Lucile Dehman, Alia Beugnet, Frederic
Published in
BMC Veterinary Research
BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are an important tool in the management of canine osteoarthritis, with the most recent introduction into the category being grapiprant, a piprant that selectively targets the EP4 prostaglandin receptor. To date there have been no efficacy studies comparing grapiprant with other NSAIDs. A rand...
