Chapter 1 provides a perspective of synthetic organic chemistry as a discipline involved in the design, synthesis and evaluation of complex molecules. The reader is introduced with a brief history of synthetic organic chemistry, all the while dealing with different aspects of synthetic organic chemistry. These aspects include design, synthesis and ...
The ability to locally functionalize the surface of glass and polymers allows for myriad biomedical and chemical applications. When we started this research enclosed surfaces such as microfluidic channels were not easily amenable to localized functionalization. Furthermore, pre-functionalization of microfluidic devices was incompatible with the typ...
Continuous flow chemistry is an enabling technique in organic chemistry. Advantages include extremely fast mixing and heat transfer capabilities as well as rapid screening of reaction conditions. Combining continuous flow chemistry with solid-supported organocatalysis presents challenges that have been investigated in this thesis. We have developed...
The synthesis and liquid crystalline ordering properties of oligomeric discotic liquid crystals were investigated. The phase behaviour and surface ordering properties are dependent on among others core type, spacer length and fluorination.
The emission of greenhouse gases in the atmosphere, particularly carbon dioxide, caused by fossil fuel combustion, has been claimed to be responsible for global warming. Capturing of carbon dioxide from exhaust gases by using aqueous amine solutions is an important process for the reduction of the emission of these gases from power plants. Monoeth...
This thesis deals with the adhesion and friction properties of densely grafted and covalently bound fluoropolymer brushes on silicon surfaces with varying thickness and fluorine content. A novel surface-functionalizing method is described using the thiol-yne click (TYC) reaction. The TYC reaction is highly useful for the attachment of functional (...
Aminozuren (AZ) zijn interessante uitgangspunten voor stikstofhoudende (amine) chemicaliën. Zij kunnen gewonnen worden als mengsel uit de hydrolyse van potentieel goedkope eiwitten verkregen van de bijproducten van de biobrandstofproductie of agrarische en voedselafvalstromen. Echter, AZ verkregen van zulke bronnen bevinden zich in een mengsel. Hie...
The aim of this thesis is to explore orientation of detection elements on biosensor
surfaces. To this end, different strategies were combined such as surface chemistry and protein functionalization, with the aim to generate a platform for oriented immobilization of antibodies
in biosensors. Chapter 2 investigates the formation of organic monolay...
The formation of fluorinated monolayers with a minimized surface energy and an improved chemical stability on specific substrates will enable outstanding tribological properties and is the main goal of the research described in this thesis. Inorganic substrates, such as Si(111), silicon carbide (SiC), chromium nitride (CrN), and organic nano-micro...
