Cox, Kristin E Turner, Michael A Lwin, Thinzar M Amirfakhri, Siamak Kelly, Kaitlyn J Hosseini, Mojgan Ghosh, Pradipta Obonyo, Marygorret Hoffman, Robert M Yazaki, Paul J
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BackgroundGastric cancer poses a major diagnostic and therapeutic challenge as surgical resection provides the only opportunity for a cure. Specific labeling of gastric cancer could distinguish resectable and nonresectable disease and facilitate an R0 resection, which could improve survival.MethodsTwo patient-derived gastric cancer lines, KG8 and K...
Ediriwickrema, Lilangi Sung, Shijun Mattick, Kaylyn An, Miranda Malley, Claire Kirk, Stephanie Devineni, Divya Lee, Jaylen Kennedy, Gordon Choi, Bernard
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SIGNIFICANCE: Spatial frequency domain imaging (SFDI) applies patterned near-infrared illumination to quantify the optical properties of subsurface tissue. The periocular region is unique due to its complex ocular adnexal anatomy. Although SFDI has been successfully applied to relatively flat in vivo tissues, regions that have significant height va...
Lee, Chi-Hua Zaman, Shamima Kundra, Vikas Anvari, Bahman
SIGNIFICANCE: Fluorescent organic dyes provide imaging capabilities at cellular and sub-cellular levels. However, a common problem associated with some of the existing dyes such as the US FDA-approved indocyanine green (ICG) is their weak fluorescence emission. Alternative dyes with greater emission characteristics would be useful in various imagin...
Sharma, Nancy Mohammad, Walaa Le Guével, Xavier Shanavas, Asifkhan
In the realm of nanomaterials, atomically precise quasi-molecular gold nanoclusters (AuNCs) play a prime role due to their unique, stable, and highly tunable optical properties. They are extensively structure-engineered for modulation of surface electronic states toward long wavelength photoluminescence, particularly in the NIR-II (1000 to 1700 nm)...
Tao, Ran Gröhl, Janek Hacker, Lina Pifferi, Antonio Roblyer, Darren Bohndiek, Sarah E
SIGNIFICANCE: The estimation of tissue optical properties using diffuse optics has found a range of applications in disease detection, therapy monitoring, and general health care. Biomarkers derived from the estimated optical absorption and scattering coefficients can reflect the underlying progression of many biological processes in tissues. AIM: ...
Baker, Andrew G Hartono, Muhamad Ou, Hui-Ling Popov, Andrea Bistrović Brown, Emma L Joseph, James Golinska, Monika González-Gualda, Estela Macias, David Ge, Jianfeng
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Publication status: Published / There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemo- or radiotherapy can be used to predict the effectiveness of cancer treatment. However, a...
Wilson, Robert H Rowland, Rebecca Kennedy, Gordon T Campbell, Chris Joe, Victor C Chin, Theresa L Burmeister, David M Christy, Robert J Durkin, Anthony J
SignificanceOver the past decade, machine learning (ML) algorithms have rapidly become much more widespread for numerous biomedical applications, including the diagnosis and categorization of disease and injury.AimHere, we seek to characterize the recent growth of ML techniques that use imaging data to classify burn wound severity and report on the...
Fang, Yile
X-ray luminescence computed tomography (XLCT) is a hybrid molecular imaging modality with the merits of both x-ray imaging (high spatial resolution) and optical imaging (high sensitivity to trace nanophosphors). Narrow x-ray beam based XLCT imaging has shown promise for both the high spatial resolution of X-ray imaging and high molecular sensitivit...
Zhang, Kangning
Compressive sensing is a method for efficiently acquiring and reconstructing a signal, through solving underdetermined linear systems. In imaging, compressive sensing theory facilitates the stable reconstruction of an image from a number of measurements fewer than the number of pixels of the image, provided the scene in question is compressible by ...
Stern, Matthew A Cole, Eric R Gross, Robert E Berglund, Ken
Published in
bioRxiv : the preprint server for biology
Genetic cellular calcium imaging has emerged as a powerful tool to investigate how different types of neurons interact at the microcircuit level to produce seizure activity, with newfound potential to understand epilepsy. Although many methods exist to measure seizure-related activity in traditional electrophysiology, few yet exist for calcium imag...