Unar, Ahsanullah Sahito, Oan Muhammad Alsawalha, Laila Afridi, Hassan Imran Ataya, Farid Shokry Bashir, Muhammad Sohail Fouad, Dalia Talpur, Farah Naz Ali, Naveed
Published in
Biological trace element research
Drug addiction is associated with significant health risks, including cardiovascular complications, cancer, and mental disorders. Illicit drugs, such as cannabinoids and opioids, including prescription medications, are widely consumed and have profound health consequences. Understanding the health effects of the toxic elements in these substances i...
Levis, Sophia C Birnie, Matthew T Xie, Yiyan Kamei, Noriko Kulkarni, Puja V Montesinos, Johanna S Perrone, Christina R Cahill, Catherine M Baram, Tallie Z Mahler, Stephen V
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Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in females, but the mechanisms for this effect are unclear. Here, we show that ELA robustly alters cFos responses to...
Zhukovsky, Peter Ironside, Maria Duda, Jessica M Moser, Amelia D Null, Kaylee E Dhaynaut, Maeva Normandin, Marc Guehl, Nicolas J El Fakhri, Georges Alexander, Madeline
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Published in
Biological psychiatry
Understanding the neurobiological effects of stress is critical for addressing the etiology of major depressive disorder (MDD). Using a dimensional approach involving individuals with differing degree of MDD risk, we investigated 1) the effects of acute stress on cortico-cortical and subcortical-cortical functional connectivity (FC) and 2) how such...
van Schalkwyk, May Ci Hawkins, Benjamin Eisenkraft Klein, Daniel Koon, Adam D
Scholars have identified notable similarities between the political strategies employed by health-harming industries. This includes similarities in the narratives employed by industry actors seeking to oppose public health regulations that threaten their commercial interests. This study seeks to examine the use of a specific concept - the balance m...
Upton, Brian A Krolick, Kristen N Zhang, Xue Pilipenko, Valentina Martin, Lisa J Ji, Hong Glynn, Susan Barnett, Kristi Ganesh, Arjunan Monitto, Constance L
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Introduction: Mu opioid receptor gene (OPRM1) variant rs1799971 introduces a CpG site, which may influence DNA methylation (DNAm) and opioid/pain outcomes. Objectives: In this nested analysis, we investigated both OPRM1 A118G genotype and promoter/immediate downstream blood DNAm sequencing data for associations with opioid effects and chronic posts...
Heshmatipour, Matthew Ng, Ding Quan Truong, Emily Yi-Wen Zheng, Jianwei Chan, Alexandre Wang, Yun
Introduction: Coronavirus 2019 (COVID-19) has had a devastating impact on mental health and access to addiction treatment in the United States, including in California, which resulted in the highest rates of emergency department visits (ED) for opioid poisoning in 2020. As California slowly returns to pre-pandemic normalcy, it remains uncertain whe...
Dean, Jon G Reyes, Mikaila Oliva, Valeria Khatib, Lora Riegner, Gabriel Gonzalez, Nailea Posey, Grace Collier, Jason Birenbaum, Julia Chakravarthy, Krishnan
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Converging lines of preclinical and clinical research indicate that females, in stark contrast to males, display an increased prevalence of chronic pain. Females also demonstrate weaker analgesic efficacy in response to opioid therapies when compared with males. These sex-specific differences may be driven by dimorphic endogenous opioidergic respon...
Patton, Thomas Boehnke, Jan R Goyal, Ravi Manca, Andrea Marienfeld, Carla Martin, Natasha K Nosyk, Bohdan Borquez, Annick
PurposeWe aimed to estimate health state utility values (HSUVs) for the key health states found in opioid use disorder (OUD) cost-effectiveness models in the published literature.MethodsData obtained from six trials representing 1,777 individuals with OUD. We implemented mapping algorithms to harmonize data from different measures of quality of lif...
Nosyk, Bohdan Min, Jeong Eun Homayra, Fahmida Kurz, Megan Guerra-Alejos, Brenda Carolina Yan, Ruyu Piske, Micah Seaman, Shaun R Bach, Paxton Greenland, Sander
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IMPORTANCE: Previous studies on the comparative effectiveness between buprenorphine and methadone provided limited evidence on differences in treatment effects across key subgroups and were drawn from populations who use primarily heroin or prescription opioids, although fentanyl use is increasing across North America. OBJECTIVE: To assess the risk...
Dong, Chunyang Gowrishankar, Raajaram Jin, Yihan He, Xinyi Jenny Gupta, Achla Wang, Huikun Sayar-Atasoy, Nilüfer Flores, Rodolfo J Mahe, Karan Tjahjono, Nikki
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Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental tools that allow for the precise dissection of their complex and diverse dynamics in a circuit-specific manner. Opioid peptides modulate pain, reward and aversion and as such have high clinical relevance. To illuminate the spat...
