Daldegan-Bueno, Dimitri Favaro, Vanessa Manchim Morais, Paulo Rogério Sussulini, Alessandra Oliveira, Maria Gabriela Menezes
Published in
Behavioural brain research
Considering the long-lasting effects of ayahuasca on the brain and emotional processing, the objective of this study was to evaluate the behavioural and neurobiological effects of repeated ayahuasca administration in an animal model of exploratory behaviour related to novel-environment anxiety. Male Wistar rats received water, 120, 240, 480 or 3600...
Yang, Guangqian Li, Jianmin Lan, Tingting Dou, Li Zhang, Kankan
Published in
Food chemistry
Penthiopyrad is a broad-spectrum fungicide with wide application in agriculture with preferential degradation of the S (+)-stereoisomer in soil. An understanding of the stereoselective fate of penthiopyrad is crucial for accurate food safety risk assessment. In this study, the dissipation, distribution, and dietary intake risk of penthiopyrad and i...
Strekalova, Tatyana Liu, Yanzhi Kiselev, Daniel Khairuddin, Sharafuddin Chiu, Jennifer Lok Yu Lam, Justin Chan, Ying-Shing Pavlov, Dmitrii Proshin, Andrey Lesch, Klaus-Peter
...
Published in
Psychopharmacology
Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago and has become a widely used model in the search for antidepressant drugs for major depression disorder (MDD). It has resulted in the publication of almost 1700 studies in rats alone. Under the original CMS procedure, the expression of an anhedonic response, a ...
Powell, William H Annett, Lucy E Depoortere, Ronan Newman-Tancredi, Adrian Iravani, Mahmoud M
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Anxiety is amongst the commonest neuropsychiatric disorders, and there is a large body of evidence to suggest that abnormalities in serotonergic function are involved in its pathogenesis. Several studies have implicated 5-HT1A receptor activation in mitigating anxiety disorders, so this study investigated the acute effects of a highly selective, po...
Frew, Jonathan Nygaard, Haakon Berge
Published in
Acta Neuropathologica Communications
Frontotemporal lobar degeneration (FTLD) causes a spectrum of clinical presentations of frontotemporal dementia (FTD), including progressive changes in behavior, personality, executive function, and language. Up to 20% of familial FTLD cases are caused by progranulin (GRN) haploinsufficiency (FTD-GRN), with one of the most common causal variant bei...
Khuleshwari, Kurrey Vijay, Paramanik
Published in
IBRO Neuroscience Reports
• The present paper reports that GENISTEIN enhances learning and memory of mouse at behavioral level. • GENISTEIN enhances ERK1/2 expression which is manifested at behavioral level. • The present paper links between the GENISTEIN and ERK1/2 from molecular level to behavioral level in the context of learning and memory.
de Leão, Ellen Rose Leandro Ponce de Souza, Dilza Nazaré Colares de Moura, Larissa Victória Barra da Silveira Júnior, Antonio Morais Dos Santos, Alinne Lorrany Gomes Diniz, Daniel Guerreiro Diniz, Cristovam Wanderley Picanço Sosthenes, Marcia Consentino Kronka
Published in
Journal of chemical neuroanatomy
Most animal model studies of autism spectrum disorder (ASD) have been performed in males, which may be a reflex of the 3-times higher prevalence in boys than in girls. For this reason, little is known about the mechanisms underlying disease progression in females, and nothing is known about potential associations between microglial changes in the l...
Tran, Fionya H Spears, Stella L Ahn, Kyung J Eisch, Amelia J Yun, Sanghee
Published in
Neuroscience letters
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are chemogenetic tools commonly-used to manipulate brain activity. The most widely-used synthetic DREADD ligand, clozapine-N-oxide (CNO), is back-metabolized to clozapine which can itself activate endogenous receptors. Studies in non-DREADD-expressing rodents suggest CNO or a DREA...
Štolhoferová, Iveta Holubová, Kristína Vobrubová, Barbora Kaftanová, Barbora Frynta, Daniel
Published in
Behavioural processes
Human settlements represent a specific environment where commensal animals are exposed to different selective pressures than their wild-living conspecifics. Despite the importance of commensal rodents for human health and economy, little is known about how a transition to a commensal way of life changes the behaviour of the animals. We tested twelv...
Taylor, Rachel M Jeong, Isaac H May, Matthew D Bergman, Elizabeth M Capaldi, Vincent F Moore, Nicole L T Matson, Liana M Lowery-Gionta, Emily G
Published in
Psychopharmacology
Evaluation of pharmacotherapies for acute stress disorder (ASD) or post-traumatic stress disorder (PTSD) is challenging due to robust heterogeneity of trauma histories and limited efficacy of any single candidate to reduce all stress-induced effects. Pursuing novel mechanisms, such as the nociceptin/orphanin FQ (NOP) system, may be a viable path fo...
