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Kosti, Adam de Araujo, Patricia Rosa Li, Wei-Qing Guardia, Gabriela D. A. Chiou, Jennifer Yi, Caihong Ray, Debashish Meliso, Fabiana Li, Yi-Ming Delambre, Talia
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Published in
Genome Biology
BackgroundRNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification and characterization of oncogenic RBPs and their regulatory networks provide new opportunities for t...
Schiuma, N. Costantino, A. Bartolotti, T. Dattilo, M. Bini, V. Aglietti, M. C. Renga, M. Favilli, A. Falorni, A. Gerli, S.
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Published in
Journal of Endocrinological Investigation
Purpose Fasting blood homocysteine is increased in PCOS women and is involved in several of its co-morbidities including cardiovascular disease and infertility. Corrective interventions based on the administration of supra-physiologic doses of folic acid work to a low extent. We aimed to test an alternative approach. Methods This was a prospective,...
Nicken, Petra Empl, Michael T Gerhard, Daniel Hausmann, Julia Steinberg, Pablo
Published in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
High consumption of red meat entails a higher risk of developing colorectal cancer. Methionine, which is more frequently a component of animal proteins, and folic acid are members of the one carbon cycle and as such important players in DNA methylation and cancer development. Therefore, dietary modifications involving altered methionine and folic a...
Dattilo, Maurizio Cornet, Dominique Amar, Edouard Cohen, Marc Menezo, Yves
Published in
Reproductive Biology and Endocrinology
BackgroundSperm chromatin structure is often impaired; mainly due to oxidative damage. Antioxidant treatments do not consistently produce fertility improvements and, when given at high doses, they might block essential oxidative processes such as chromatin compaction. This study was intended to assess the effect on male sub-fertility of a pure one ...
Lin, Da-Wei Chung, Benjamin P Kaiser, Peter
Published in
Journal of cell science
The primary methyl group donor S-adenosylmethionine (SAM) is important for a plethora of cellular pathways including methylation of nucleic acids, proteins, and the 5' cap structure of mRNAs, as well as biosynthesis of phospholipids and polyamines. In addition, because it is the cofactor for chromatin methylation, SAM is an important metabolite for...