Liao, Yu-Mei Wang, Ya-Hui Hung, Jung-Tung Lin, Yu-Ju Huang, Yen-Lin Liao, Guo-Shiou Hsu, Ya-Ling Wu, Jen-Chien Yu, Alice L
BackgroundExistence of breast cancer stem cells (BCSCs) is implicated in disease relapse, metastasis, and resistance of treatment. β1,3-Galactosyltransferase 5 (B3GALT5) has been shown to be a pro-survival marker for BCSCs. However, little is known about the prognostic significance of B3GALT5 in breast cancer.MethodsPaired tissues (tumor part and a...
Sabeti, Sara Ball, Karen L Burkhart, Craig Eichenfield, Lawrence Fernandez Faith, Esteban Frieden, Ilona J Geronemus, Roy Gupta, Deepti Krakowski, Andrew C Levy, Moise L
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ImportanceSturge-Weber syndrome (SWS) is a neurocutaneous syndrome involving the skin, brain, and eyes. Consensus recommendations for management are lacking.ObjectiveTo consolidate the current literature with expert opinion to make recommendations that will guide treatment and referral for patients with port-wine birthmarks (PWBs).Evidence reviewIn...
Grasso, Catherine S Tsoi, Jennifer Onyshchenko, Mykola Abril-Rodriguez, Gabriel Ross-Macdonald, Petra Wind-Rotolo, Megan Champhekar, Ameya Medina, Egmidio Torrejon, Davis Y Shin, Daniel Sanghoon
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Wyrwich, KW Kitchen, H Knight, S Aldhouse, NVJ Macey, J Nunes, FP Dutronc, Y Mesinkovska, N Ko, JM King, BA
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BackgroundValid patient-reported outcome (PRO) measures are required to evaluate alopecia areata (AA) treatments.ObjectivesTo develop a content-valid and clinically meaningful PRO measure to assess AA scalp hair loss with scores comparable with the five-response-level Alopecia Areata Investigator Global Assessment (AA-IGA™).MethodsA draft PRO measu...
Li, Fangda Meyer, April N Peiris, Malalage N Nelson, Katelyn N Donoghue, Daniel J
Aim of studyChromosomal translocations such as t(10;12)(q26,q12) are associated with intrahepatic cholangiocarcinoma, a universally fatal category of liver cancer. This translocation creates the oncogenic fusion protein of Fibroblast Growth Factor Receptor 2 joined to Periphilin 1. The aims of this study were to identify significant features requir...
Lewis, Elizabeth C Kraveka, Jacqueline M Ferguson, William Eslin, Don Brown, Valerie I Bergendahl, Genevieve Roberts, William Wada, Randal K Oesterheld, Javier Mitchell, Deanna
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Neuroblastoma is a sympathetic nervous system tumor, primarily presenting in children under 6 years of age. The long-term prognosis for patients with high-risk neuroblastoma (HRNB) remains poor despite aggressive multimodal therapy. This report provides an update to a phase II trial evaluating DFMO as maintenance therapy in HRNB. Event-free surviva...
Gresham, Gillian Diniz, Márcio A Razaee, Zahra S Luu, Michael Kim, Sungjin Hays, Ron D Piantadosi, Steven Tighiouart, Mourad Yothers, Greg Ganz, Patricia A
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BackgroundThe National Cancer Institute Moonshot research initiative calls for improvements in the analysis and reporting of treatment toxicity to advise key stakeholders on treatment tolerability and inform regulatory and clinical decision making. This study illustrates alternative approaches to toxicity evaluation using the National Surgical Adju...
Rosenberg, Shai Okamura, Ryosuke Kato, Shumei Soussi, Thierry Kurzrock, Razelle
Interrogating the genomics of circulating tumor DNA (ctDNA; the liquid biopsy) has advantages in patients in whom tissue biopsy is difficult. However, the reported concordance between genomic analysis of tissue DNA and ctDNA is variable among studies. Herein, we characterized the clinical implications of the relationship between mutations in TP53 g...
Li, Weiyu Denton, Brian T Nieboer, Daan Carroll, Peter R Roobol, Monique J Morgan, Todd M foundation’s, movember
This study aimed to estimate the rates of biopsy undersampling and progression for four prostate cancer (PCa) active surveillance (AS) cohorts within the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) consortium. We used a hidden Markov model (HMM) to estimate factors that define PCa dynamics for men on AS inclu...
Hollandsworth, Hannah M Schmitt, Verena Amirfakhri, Siamak Filemoni, Filemoni Schmidt, Alexej Landström, Maréne Lyndin, Mykola Backert, Steffen Gerhard, Markus Wennemuth, Gunther
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HopQ is an outer-membrane protein of Helicobacter pylori that binds to human carcinoembryonic antigen-related cell-adhesion molecules (CEACAMs) with high specificity. We aimed to investigate fluorescence targeting of CEACAM-expressing colorectal tumors in patient-derived orthotopic xenograft (PDOX) models with fluorescently labeled recombinant HopQ...