Liao, Yu-Mei Wang, Ya-Hui Hung, Jung-Tung Lin, Yu-Ju Huang, Yen-Lin Liao, Guo-Shiou Hsu, Ya-Ling Wu, Jen-Chien Yu, Alice L
BackgroundExistence of breast cancer stem cells (BCSCs) is implicated in disease relapse, metastasis, and resistance of treatment. β1,3-Galactosyltransferase 5 (B3GALT5) has been shown to be a pro-survival marker for BCSCs. However, little is known about the prognostic significance of B3GALT5 in breast cancer.MethodsPaired tissues (tumor part and a...
Liu, Chuanxia Billet, Sandrine Choudhury, Diptiman Cheng, Ran Haldar, Subhash Fernandez, Ana Biondi, Shea Liu, Zhenqiu Zhou, Hongmei Bhowmick, Neil A
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Head and neck cancers are often diagnosed at later stages with poor outcomes. Mesenchymal stem cells (MSC) are recruited to primary tumor sites where they can have pro- and antitumorigenic influence. In trying to better understand the dynamics between MSC and cancer cells, we found that head and neck cancer-MSC exposure resulted in mesenchymal feat...
Grasso, Catherine S Tsoi, Jennifer Onyshchenko, Mykola Abril-Rodriguez, Gabriel Ross-Macdonald, Petra Wind-Rotolo, Megan Champhekar, Ameya Medina, Egmidio Torrejon, Davis Y Shin, Daniel Sanghoon
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Li, Fangda Meyer, April N Peiris, Malalage N Nelson, Katelyn N Donoghue, Daniel J
Aim of studyChromosomal translocations such as t(10;12)(q26,q12) are associated with intrahepatic cholangiocarcinoma, a universally fatal category of liver cancer. This translocation creates the oncogenic fusion protein of Fibroblast Growth Factor Receptor 2 joined to Periphilin 1. The aims of this study were to identify significant features requir...
Lewis, Elizabeth C Kraveka, Jacqueline M Ferguson, William Eslin, Don Brown, Valerie I Bergendahl, Genevieve Roberts, William Wada, Randal K Oesterheld, Javier Mitchell, Deanna
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Neuroblastoma is a sympathetic nervous system tumor, primarily presenting in children under 6 years of age. The long-term prognosis for patients with high-risk neuroblastoma (HRNB) remains poor despite aggressive multimodal therapy. This report provides an update to a phase II trial evaluating DFMO as maintenance therapy in HRNB. Event-free surviva...
Gresham, Gillian Diniz, Márcio A Razaee, Zahra S Luu, Michael Kim, Sungjin Hays, Ron D Piantadosi, Steven Tighiouart, Mourad Yothers, Greg Ganz, Patricia A
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BackgroundThe National Cancer Institute Moonshot research initiative calls for improvements in the analysis and reporting of treatment toxicity to advise key stakeholders on treatment tolerability and inform regulatory and clinical decision making. This study illustrates alternative approaches to toxicity evaluation using the National Surgical Adju...
Rosenberg, Shai Okamura, Ryosuke Kato, Shumei Soussi, Thierry Kurzrock, Razelle
Interrogating the genomics of circulating tumor DNA (ctDNA; the liquid biopsy) has advantages in patients in whom tissue biopsy is difficult. However, the reported concordance between genomic analysis of tissue DNA and ctDNA is variable among studies. Herein, we characterized the clinical implications of the relationship between mutations in TP53 g...
Hollandsworth, Hannah M Schmitt, Verena Amirfakhri, Siamak Filemoni, Filemoni Schmidt, Alexej Landström, Maréne Lyndin, Mykola Backert, Steffen Gerhard, Markus Wennemuth, Gunther
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HopQ is an outer-membrane protein of Helicobacter pylori that binds to human carcinoembryonic antigen-related cell-adhesion molecules (CEACAMs) with high specificity. We aimed to investigate fluorescence targeting of CEACAM-expressing colorectal tumors in patient-derived orthotopic xenograft (PDOX) models with fluorescently labeled recombinant HopQ...
Gu, Wanjun Shi, Junchao Liu, Hui Zhang, Xudong Zhou, Jin J Li, Musheng Zhou, Dandan Li, Rui Lv, Jingzhu Wen, Guoxia
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One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB). To identify reliable biomarkers for lung cancer screening, we leverage the recently discovered non-canonical small non-coding RNAs (i.e., tRNA...
Zagorac, S De Giorgio, A Dabrowska, A Kalisz, M Casas-Vila, N Cathcart, P Yiu, A Ottaviani, S Degani, N Lombardo, Y
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In many tumors, cells transition reversibly between slow-proliferating tumor-initiating cells (TIC) and their differentiated, faster-growing progeny. Yet how transcriptional regulation of cell cycle and self-renewal genes is orchestrated during these conversions remains unclear. In this study, we show that as breast TIC form, a decrease in cell-cyc...