Gilson, Pauline Levy, Julien Rouyer, Marie Demange, Jessica Husson, Marie Bonnet, Céline Salleron, Julia Leroux, Agnès Merlin, Jean-Louis Harlé, Alexandre
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Published in
Scientific Reports
Microsatellite instability (MSI) status is routinely assessed in patients with colorectal and endometrial cancers as it contributes to Lynch syndrome initial screening, tumour prognosis and selecting patients for immunotherapy. Currently, standard reference methods recommended for MSI/dMMR (deficient MisMatch Repair) testing consist of immunohistoc...
Ferrua, Marie Minvielle, Etienne Fourcade, Aude Lalloué, Benoît Sicotte, Claude Di Palma, Mario Mir, Olivier
Published in
BMC Health Services Research
BackgroundRemote Patient Monitoring Systems (RPMS) based on e-health, Nurse Navigators (NNs) and patient engagement can improve patient follow-up and have a positive impact on quality of care (by limiting adverse events) and costs (by reducing readmissions). However, the extent of this impact depends on effective implementation which is often restr...
Schneider, Justine Schlüter, Kathrin Sprave, Tanja Wiskemann, Joachim Rosenberger, Friederike
Published in
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Most studies with cancer survivors use percentages of peak oxygen uptake (VO2peak) for intensity prescription. Lactate or ventilatory thresholds might be useful submaximal alternatives, but this has never been investigated. Therefore, we aimed at comparing three training sessions prescribed using %VO2peak (reference), lactate thresholds, and ventil...
Kim, Soon Sun Eun, Jung Woo Choi, Ji-Hye Woo, Hyun Goo Cho, Hyo Jung Ahn, Hye Ri Suh, Chul Won Baek, Geum Ok Cho, Sung Won Cheong, Jae Youn
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Published in
Scientific Reports
Liquid biopsy can provide a strong basis for precision medicine. We aimed to identify novel single-nucleotide variants (SNVs) in circulating tumor DNA (ctDNA) in patients with hepatocellular carcinoma (HCC). Deep sequencing of plasma-derived ctDNA from 59 patients with HCC was performed using a panel of 2924 SNVs in 69 genes. In 55.9% of the patien...
Zhao, Jie Ma, Yong Tanimoto, Tetsuya Ozaki, Akihiko Chen, Wan-Li Wang, Jing-Ya Zhang, Yu-Xin Chen, Lin-Li Wang, Ji-Wei Yu, Jin-Ming
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Published in
Scientific Reports
This study aims to investigate the serial multiple mediation of physical activity and perceived stress in the relationship between individual social capital and quality of life (QOL) in breast cancer survivors (BCSs). This study was conducted among 520 BCSs between March and April 2017 in Shanghai, China. Data were collected using the Individual So...
Shin, Tae Young Lee, Yong Seong
Published in
Scientific Reports
Various neurovascular bundle-sparing techniques have been introduced to maximize recovery of erectile function after robot-assisted radical prostatectomy (RARP). The clipless intrafascial neurovascular bundle-sparing technique aims to preserve periprostatic structures and neurovascular bundles as much as possible by avoiding clipping of the vascula...
Sabdyusheva Litschauer, Inna Becker, Klaus Saghafi, Saiedeh Ballke, Simone Bollwein, Christine Foroughipour, Meraaj Gaugeler, Julia Foroughipour, Massih Schavelová, Viktória László, Viktória
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Published in
Scientific Reports
Here, we describe a novel approach that allows pathologists to three-dimensionally analyse malignant tissues, including the tumour-host tissue interface. Our visualization technique utilizes a combination of ultrafast chemical tissue clearing and light-sheet microscopy to obtain virtual slices and 3D reconstructions of up to multiple centimetre siz...
O’Leary, Brianne R. Alexander, Matthew S. Du, Juan Moose, Devon L. Henry, Michael D. Cullen, Joseph J.
Published in
Scientific Reports
Pharmacological ascorbate (P-AscH−, high-dose, intravenous vitamin C) is cytotoxic to tumor cells in doses achievable in humans. Phase I studies in pancreatic cancer (PDAC) utilizing P-AscH− have demonstrated increases in progression free survival, suggesting a reduction in metastatic disease burden. The purpose of this study was to determine the e...
Newton, Yulia Sedgewick, Andrew J. Cisneros, Luis Golovato, Justin Johnson, Mark Szeto, Christopher W. Rabizadeh, Shahrooz Sanborn, J. Zachary Benz, Stephen Charles Vaske, Charles
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Published in
Scientific Reports
Transcriptome profiling can provide information of great value in clinical decision-making, yet RNA from readily available formalin-fixed paraffin-embedded (FFPE) tissue is often too degraded for quality sequencing. To assess the clinical utility of FFPE-derived RNA, we performed ribo-deplete RNA extractions on > 3200 FFPE slide samples; 25 of thes...
Shenoy, Niraj
Published in
Scientific Reports
HIF1α has been termed a tumor-suppressor in clear cell renal cell carcinoma (ccRCC), primarily based on functional proliferation studies in cell lines (in vitro and in vivo) with genetic manipulation, and the adverse prognosis of 14q-deleted ccRCC patients. In other malignancies, however, HIF1α has an established tumor-promoting role. Therefore, th...
