Penco, Silvia Rotili, Anna Pesapane, Filippo Trentin, Chiara Dominelli, Valeria Faggian, Angela Farina, Mariagiorgia Marinucci, Irene Bozzini, Anna Pizzamiglio, Maria
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Published in
Medical Oncology
MRI-guided vacuum-assisted breast biopsy (VABB) is used for suspicious breast cancer (BC) lesions which are detectable only with MRI: because the high sensitivity but limited specificity of breast MRI it is a fundamental tool in breast imaging divisions. We analyse our experience of MRI-guided VABB and critically discuss the potentialities of diffu...
Devlin, Elise J Whitford, Hayley S Denson, Linley A Potter, Andrew E
Published in
Journal of psychosomatic research
Response expectancies of cancer treatment toxicities are often, but not always, associated with subsequent experiences. A recent meta-analysis indicated that response expectancies, measured using different assessment formats, reveal different effect sizes, potentially explaining mixed outcomes. Utilizing a clinical sample, we compared 5-point asses...
Gresham, Gillian Diniz, Márcio A Razaee, Zahra S Luu, Michael Kim, Sungjin Hays, Ron D Piantadosi, Steven Tighiouart, Mourad Yothers, Greg Ganz, Patricia A
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BACKGROUND:The National Cancer Institute Moonshot℠ research initiative calls for improvements in the analysis and reporting of treatment toxicity to advise key stakeholders on treatment tolerability and inform regulatory and clinical decision-making. This study illustrates alternative approaches to toxicity evaluation using the National Surgical Ad...
Dayoub, Adam S. Brekken, Rolf A.
Published in
Cell Communication and Signaling
Immunotherapy for cancer is making impressive strides at improving survival of a subset of cancer patients. To increase the breadth of patients that benefit from immunotherapy, new strategies that combat the immunosuppressive microenvironment of tumors are needed. Phosphatidylserine (PS) signaling is exploited by tumors to enhance tumor immune evas...
Ikeuchi, Kaori Ishiguro, Hiroshi Nakamura, Yasunori Izawa, Tomoko Shinkura, Nobuhiko Nin, Kazuko
Published in
BioPsychoSocial Medicine
BackgroundAlthough fatigue is a common and distressing symptom in cancer survivors, the mechanism of fatigue is not fully understood. Therefore, this study aims to investigate the relation between the fatigue and mindfulness of breast cancer survivors using anxiety, depression, pain, loneliness, and sleep disturbance as mediators.MethodsPath analys...
Nic Giolla Easpaig, Bróna Tran, Yvonne Bierbaum, Mia Arnolda, Gaston Delaney, Geoff P. Liauw, Winston Ward, Robyn L. Olver, Ian Currow, David Girgis, Afaf
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Published in
BMC Health Services Research
BackgroundThe adoption of Patient Reported Outcome Measures (PROMs) in cancer care has been widely advocated, but little is known about the evidence for the implementation of PROMs in practice. Qualitative research captures the perspectives of health professionals as end-users of PROMs and can be used to inform adoption efforts. This paper presents...
salvati, maurizio bruzzaniti, placido relucenti, michela nizzola, mariagrazia familiari, pietro giugliano, marco scafa, anthony kevin galletta, santi xiaobo, li chen, rui
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Glioblastoma is a solid, infiltrating, and the most frequent highly malignant primary brain tumor. Our aim was to find the correlation between sex, age, preoperative Karnofsky performance status (KPS), presenting with seizures, and extent of resection (EOR) with overall survival (OS), progression-free survival (PFS), and postoperative KPS, along wi...
Ashmore-Harris, Candice Fruhwirth, Gilbert O.
Published in
Clinical and Translational Medicine
The clinical application of ex vivo gene edited cell therapies first began a decade ago with zinc finger nuclease editing of autologous CD4+ T-cells. Editing aimed to disrupt expression of the human immunodeficiency virus co-receptor gene CCR5, with the goal of yielding cells resistant to viral entry, prior to re-infusion into the patient. Since th...
Lam, E Gong, C Fujino, K
Eukaryotic translation initiation factor 4E (eIF4E) selectively promotes translation of mRNAs with atypically long and structured 5′-UTRs and has been implicated in drug resistance. Through genome-wide transcriptome and translatome analysis we revealed eIF4E overexpression could promote cellular activities mediated by ERα and FOXM1 signalling pathw...
Bergqvist, Christina Servy, Amandine Valeyrie-Allanore, Laurence Ferkal, Salah Combemale, Patrick Wolkenstein, Pierre Adamski, Henri Baumann-Morel, Clarisse Bellanné, Christine Bieth, Eric
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Published in
Orphanet Journal of Rare Diseases
Neurofibromatosis type 1 is a relatively common genetic disease, with a prevalence ranging between 1/3000 and 1/6000 people worldwide. The disease affects multiple systems with cutaneous, neurologic, and orthopedic as major manifestations which lead to significant morbidity or mortality. Indeed, NF1 patients are at an increased risk of malignancy a...
