Malignant pleural mesothelioma (MPM) is a rare and highly aggressive cancer affecting the pleura and is mainly caused by asbestos exposure. Prognosis for MPM patients remains globally poor notably due to the advanced stage of the disease at presentation and because of its resistance to available treatments. Therapeutic approaches have been disappoi...
Published in Physiotherapy theory and practice
Cancer-related fatigue (CRF) is a common side effect and remains under-diagnosed. Screening of CRF by physical therapists (PTs) and patient perspectives of their experiences has not been comprehensively examined. To survey PTs to understand the frequency of CRF screening, and to assess the knowledge and experiences of survivors as it relates to CRF...
Published in North American Spine Society journal
Motor function in patients with spinal metastatic disease (SMD) directly impacts a patient's ability to receive systemic therapy and overall survival. Spine surgeons may be in the challenging position to advise a patient on expected motor function outcomes and determine a patient's suitability as a surgical candidate. We present this study to provi...
Published in Journal of cancer research and clinical oncology
Immune checkpoint inhibition therapy (ICIT) is an emerging field in oncology especially opening new horizons to chemotherapy refractory patients. However, immune-related adverse events (irAEs) and undesired response patterns such as progression after the initial good response in a subset of patients pose a major challenge and drawback to ICIT. This...
status: accepted
La recherche clinique dans le domaine de la cancérologie est essentielle afin d’améliorer la prise en charge des patients, tant en termes de survie globale que de qualité de vie. La mise en œuvre des essais cliniques de médicaments, relevant désormais du règlement UE 536/2014, est conditionnée à une autorisation scientifique préalable de l’Agence n...
peer reviewed / [en] BACKGROUND AND AIMS: Polycystic liver disease (PLD) can lead to extensive hepatomegaly. Symptom relief is the primary goal of the treatment. The role of the recently developed disease-specific questionnaires for identification of the thresholds and the assessment of therapy needs further investigation. METHODS: A five-year pros...
INTRODUCTION: As the population is ageing, the number of older patients with multimorbidity including cancer continues to increase. To improve care for these patients, the European Union-funded project "Streamlined Geriatric and Oncological evaluation based on IC Technology" (GERONTE) was initiated to develop a new, patient-centred, holistic care p...
The Society of Abdominal Radiologys Colorectal and Anal Cancer Disease-Focused Panel (DFP) first published a rectal cancer lexicon paper in 2019. Since that time, the DFP has published revised initial staging and restaging reporting templates, and a new SAR user guide to accompany the rectal MRI synoptic report (primary staging). This lexicon updat...
peer reviewed / [en] PURPOSE: Tissue factor is highly expressed in cervical carcinoma and can be targeted by tisotumab vedotin (TV), an antibody-drug conjugate. This phase Ib/II study evaluated TV in combination with bevacizumab, pembrolizumab, or carboplatin for recurrent or metastatic cervical cancer (r/mCC). METHODS: This open-label, multicenter...
