Zeng, Chengbing Zhai, Tiantian Chen, Jianzhou Guo, Longjia Huang, Baotian Guo, Hong Liu, Guozhi Zhuang, Tingting Liu, Weitong Luo, Ting
...
Published in
Radiation Oncology
BackgroundThis study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for the treatment outcomes of patients with oesophageal squamous cell carcinoma (OSCC) after definitive concurrent chemoradiotherapy (CCRT).MethodsAltogether, 154 patients with OSCC who underwent definitive C...
van Holstein, Yara van Deudekom, Floor J. Trompet, Stella Postmus, Iris Uit den Boogaard, Anna van der Elst, Marjan J. T. de Glas, Nienke A. van Heemst, Diana Labots, Geert Altena, Mariëtte
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Published in
BMC Geriatrics
BackgroundTreatment decisions concerning older patients can be very challenging and individualised treatment plans are often required in this very heterogeneous group. In 2015 we have implemented a routine clinical care pathway for older patients in need of intensive treatment, including a comprehensive geriatric assessment (CGA) that was used to s...
Koemans, Willem J Larue, Ruben T H M Kloft, Maximilian Ruisch, Jessica E Compter, Inge Riedl, Robert G Heij, Lara R van Elmpt, Wouter Berbée, Maaike Buijsen, Jeroen
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Published in
Esophagus : official journal of the Japan Esophageal Society
The presence of lymph node metastasis (LNmets) is a poor prognostic factor in oesophageal cancer (OeC) patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgery. Tumour regression grade (TRG) in LNmets has been suggested as a predictor for survival. The aim of this study was to investigate whether TRG in LNmets is related to th...
Attia, Hossameldin Smyth, Elizabeth
Published in
Expert review of anticancer therapy
Oesophago-gastric cancers remain a considerable health burden and among the top causes of global cancer-related deaths. Chemotherapy remains the cornerstone of treatment for patients with advanced disease. Doublet platinum/fluoropyrimidine therapy is established as first-line treatment with the option of adding a taxane in selected patients. Irinot...
Chen, Shao-bin Liu, Di-tian Huang, Shu-jie Weng, Hong-rui Wang, Geng Li, Hua Chen, Yu-ping
Published in
Scientific Reports
To investigate the prognostic value of occult lymph node metastases (OLNMs) in patients with pathologically lymph node negative (pN0) esophageal squamous cell carcinoma (ESCC). OLNMs were detected in 516 pN0 ESCC patients by immunohistochemical staining. The correlation between the clinicopathological features and OLNM, and the prognostic value of ...
Thomas, Melissa; Mortensen, Hanna R; Hoffmann, Lone; Møller, Ditte S; Troost, Esther GC; Muijs, Christina T; Berbee, Maaike; Bütof, Rebecca; Nicholas, Owen; Radhakrishna, Ganesh;
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PURPOSE: To define instructions for delineation of target volumes in the neoadjuvant setting in oesophageal cancer. MATERIALS AND METHODS: Radiation oncologists of five European centres participated in the following consensus process: [1] revision of published (MEDLINE) and national/institutional delineation guidelines; [2] first delineation round ...
Mallet, Romain Modzelewski, Romain Lequesne, Justine Mihailescu, Sorina Decazes, Pierre Auvray, Hugues Benyoucef, Ahmed Di Fiore, Fréderic Vera, Pierre Dubray, Bernard
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Published in
Radiation Oncology
BackgroundSarcopenia is defined by a loss of skeletal muscle mass with or without loss of fat mass. Sarcopenia has been associated to reduced tolerance to treatment and worse prognosis in cancer patients, including patients undergoing surgery for limited oesophageal cancer. Concomitant chemo-radiotherapy is the standard treatment for locally-advanc...
Lin, Yuan Luo, Yingying Sun, Yanxia Guo, Wenjia Zhao, Xuan Xi, Yiyi Ma, Yuling Shao, Mingming Tan, Wen Gao, Ge
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Published in
Nature Communications
Adenocarcinoma at the gastroesophageal junction has a dismal prognosis and few drug options. Here, the authors present genomic and transcriptomic features and potential therapeutic targets and prognostic biomarkers of Chinese and Caucasian tumours, and reveal the molecular similarities.
Baram, Aram Sherzad, Hiwa
Published in
The Cardiothoracic Surgeon
BackgroundOesophageal carcinoma (EC) is the eighth most common cancer. Surgery is the cornerstone of management for resectable EC. Trans-thoracic oesophagectomy (TTE) and trans-hiatal oesophagectomy (THE) are the two most widely practised procedures. Most of the related controversies are centred on both early and late post-operative complications a...
Lehman, Heather L. Kidacki, Michal Stairs, Douglas B.
Published in
Scientific Reports
Esophageal squamous cell carcinoma (ESCC) is among the most aggressive and fatal cancer types. ESCC classically progresses rapidly and frequently causes mortality in four out of five patients within two years of diagnosis. Yet, little is known about the mechanisms that make ESCC so aggressive. In a previous study we demonstrated that p120-catenin (...
