Wu, Wanhong Ke, Meng Ye, Lingling Lin, Cuihong
Published in
European journal of clinical pharmacology
U.S. Food and Drug Administration (FDA) recommended telavancin dosing is based on total body weight (TBW) but lacks adjusted regimens for obese subjects with varying renal function. Our aim was to develop a physiologically based pharmacokinetic (PBPK) model of telavancin to design optimized dosing regimens for obese patients with hospital-acquired ...
Ellulu, Mohammed S Naser, Ihab A Abuhajar, Sahar M Najim, Ahmed A
Published in
Current medical research and opinion
to determine the risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus. A total of 164 hypertensive patients with type 2 diabetes patients aged 38 to 60 years were selected from 7 primary healthcare centers in Gaza city, Palestine. Interview questionnaire were employed to collect data related to age, gende...
Kingston, Andrew Byles, Julie Kiely, Kim Anstey, Kaarin J Jagger, Carol
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Smoking and obesity are 2 modifiable risk factors for disability. We examine the impact of smoking and obesity on disability-free life expectancy (DFLE) at older ages, using 2 levels of disability. We used the DYNOPTA dataset, derived by harmonizing and pooling risk factors and disability outcomes from 5 Australian longitudinal aging studies. We de...
Esmail, Mohammed Anwar, Shehata Kandeil, Mohammed El-Zanaty, Ali Mahmoud Abdel-Gabbar, Mohammed
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Obesity is increasing rapidly across the globe. It is widely accepted that natural products with a long safety background may modulate obesity. The current work aimed to investigate the effect of Nigella sativa, atorvastatin, or L-Carnitine on high-fat diet-induced obesity in white male albino rats. A regular basal diet was fed to 7 rats, and a hig...
La Sala, Lucia Tagliabue, Elena Vieira, Elaine Pontiroli, Antonio E Folli, Franco
Published in
Cardiovascular Diabetology
BackgroundInformation about the renin–angiotensin–aldosterone system (RAAS) in obese individuals before and after bariatric surgery is scarce. Aim of this study was to analyze the RAAS in severely obese subjects, in relation to anthropometric and metabolic variables, with special reference to glucose tolerance.Methods239 subjects were evaluated at ...
Amininezhad, Farzaneh Payab, Moloud Sharifi, Farshad Ostovar, Afshin Mehrdad, Neda Heshmat, Ramin Hadizadeh, Alireza Bagherzadeh, Mohammad Shafiee, Gita Shadman, Zhaleh
...
Published in
Archives of Osteoporosis
IntroductionObesity and osteoporosis are health problems with high impact on the morbidity and mortality rate. While the association between BMI and bone density is known, the combined effects of obesity and metabolic components on bone health have not yet been revealed. The objectives of this study were to determine the association between bone he...
Sylwander, Charlotte Larsson, Ingrid Haglund, Emma Bergman, Stefan Andersson, Maria L.E.
Published in
BMC Musculoskeletal Disorders
BackgroundKnee osteoarthritis (KOA), chronic widespread pain (CWP) and overweight/obesity are public health problems that often coincide, and there is a multifactorial and unclear relationship between them. The study aimed to (1) investigate pain sensitivity, assessed by pressure pain thresholds (PPTs), among women and men with knee pain and (2) as...
Yazdanpanah, Mohammad Hosein Bahramali, Ehsan Naghizadeh, Mohammad Mehdi Farjam, Mojtaba Mobasheri, Maryam Dadvand, Shiva
Published in
BMC Cardiovascular Disorders
BackgroundPrevious studies suggested that obesity and fat mass are associated with QT interval prolongation, but the role of different body parts' fat mass is unclear. The associations between total and regional fat mass (FM) and corrected QT interval (QTc) were investigated for the first time in this study.MethodsIn this sub-analysis of Fasa PERSI...
Patte, Karen A. Livermore, Maram Qian, Wei Leatherdale, Scott T.
Published in
BMC Public Health
BackgroundThe purpose of this study was to explore whether the way youth perceive their weight and their experiences of bullying victimization account for the increased risk of depression and anxiety symptoms, and poor psychosocial well-being, associated with overweight/obesity in a large sample of Canadian secondary school students. We also explor...
Becker, Amanda Gaballa, Dianna Roslin, Mitchell Gianos, Eugenia Kane, Jamie
Published in
Current Cardiology Reports
Purpose of ReviewCardiovascular disease (CVD) is highly associated with obesity and cardiometabolic dysfunction. This review will focus on three novel therapies that have been identified for potential treatment of obesity and its associated CVD risk factors.Recent FindingsIntermittent fasting (IF) studies in animal models have shown improvements in...
