Zhang, Xiaoyu Xu, Hanfei Li, Gloria Hy Long, Michelle T Cheung, Ching-Lung Vasan, Ramachandran S Hsu, Yi-Hsiang Kiel, Douglas P Liu, Ching-Ti
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Osteoporosis, a disease characterized by low bone mineral density (BMD), increases the risk for fractures. Conventional risk factors alone do not completely explain measured BMD or osteoporotic fracture risk. Metabolomics may provide additional information. We aim to identify BMD-associated metabolomic markers that are predictive of fracture risk. ...
Robinson, Danielle E Ali, M Sanni Pallares, Natalia Tebé, Cristian Elhussein, Leena Abrahamsen, Bo Arden, Nigel K Ben-Shlomo, Yoav Caskey, Fergus J Cooper, Cyrus
...
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Bisphosphonates are the first-line treatment for preventing fractures in osteoporosis patients. However, their use is contraindicated or to be used with caution in chronic kidney disease (CKD) patients, primarily because of a lack of information about their safety and effectiveness. We aimed to investigate the safety of oral bisphosphonates in pati...
Miao, Dengshun Goltzman, David
Published in
JBMR Plus
Genetically modified mice have provided novel insights into the mechanisms of activation and inactivation of vitamin D, and in the process have provided phenocopies of acquired human disease such as rickets and osteomalacia and inherited diseases such as pseudovitamin D deficiency rickets, hereditary vitamin D resistant rickets, and idiopathic infa...
Wren, Tishya AL Mueske, Nicole M Rethlefsen, Susan A Kay, Robert M Van Speybroeck, Alexander Mack, Wendy J
Published in
JBMR Plus
Pathologic fractures of the femur and tibia are common in youth with spina bifida (SB). These fractures may be associated with deficient bone accrual due to decreased ambulation and skeletal loading. This prospective cohort study used quantitative computed tomography (QCT) to assess three‐dimensional (3D) bone properties in children and adolescents...
Yau, Michelle S Kuipers, Allison L Price, Ryan Nicolas, Aude Tajuddin, Salman M Handelman, Samuel K Arbeeva, Liubov Chesi, Alessandra Hsu, Yi-Hsiang Liu, Ching-Ti
...
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Genetic studies of bone mineral density (BMD) largely have been conducted in European populations. We therefore conducted a meta-analysis of six independent African ancestry cohorts to determine whether previously reported BMD loci identified in European populations were transferable to African ancestry populations. We included nearly 5000 individu...
Martínez‐Gil, Núria Roca‐Ayats, Neus Atalay, Nurgül Pineda‐Moncusí, Marta Garcia‐Giralt, Natàlia Van Hul, Wim Boudin, Eveline Ovejero, Diana Mellibovsky, Leonardo Nogués, Xavier
...
Published in
JBMR Plus
The DKK1 gene encodes an extracellular inhibitor of the Wnt pathway with an important role in bone tissue development, bone homeostasis, and different critical aspects of bone biology. Several BMD genome‐wide association studies (GWASs) have consistently found association with SNPs in the DKK1 genomic region. For these reasons, it is important to a...
D'Silva, Kristin M Cromer, Sara Jane Yu, Elaine W Fischer, Michael Kim, Seoyoung C
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Zoledronic acid (ZA) is an effective agent in osteoporosis and malignancy-related bone disease but may be associated with increased risk of atrial fibrillation (AF), although current studies disagree on this risk. To examine the risk of incident AF among patients receiving ZA compared with denosumab in the first year of treatment, we performed a ne...
Harrison, Kim D. Hiebert, Beverly D. Panahifar, Arash Andronowski, Janna M. Ashique, Amir M. King, Gavin A. Arnason, Terra Swekla, Kurtis J. Pivonka, Peter Cooper, David M.L.
...
Cortical bone porosity is intimately linked with remodeling, is of growing clinical interest, and is increasingly accessible by imaging. Thus, the potential of animal models of osteoporosis (OP) to provide a platform for studying how porosity develops and responds to interventions is tremendous. To date, rabbit models of OP have largely focused on ...
Møller, Anaïs M J Delaisse, Jean‐Marie Olesen, Jacob B Bechmann, Troels Madsen, Jonna S Søe, Kent
Published in
JBMR Plus
Zoledronic acid is a bisphosphonate commonly used to treat bone diseases such as osteoporosis and cancer‐induced bone disease. Patients exhibit a variable sensitivity to zoledronic acid; the underlying explanation for this remains unclear. The objective of this study was to obtain more knowledge in this regard. We hypothesized that osteoclasts gene...
Harrison, Kim D Hiebert, Beverly D Panahifar, Arash Andronowski, Janna M Ashique, Amir M King, Gavin A Arnason, Terra Swekla, Kurtis J Pivonka, Peter Cooper, David ML
...
Published in
Journal of Bone and Mineral Research
Cortical bone porosity is intimately linked with remodeling, is of growing clinical interest, and is increasingly accessible by imaging. Thus, the potential of animal models of osteoporosis (OP) to provide a platform for studying how porosity develops and responds to interventions is tremendous. To date, rabbit models of OP have largely focused on ...
