Published in Biomedical Optics Express
Second harmonic generation (SHG) imaging microscopy of thick biological tissues is affected by the presence of aberrations and scattering within the sample. Moreover, additional problems, such as uncontrolled movements, appear when imaging in-vivo . Deconvolution methods can be used to overcome these limitations under some conditions. In particular...
An unsupervised deconvolution method has been proposed to enhance the quality and resolution of second harmonic generation images of the living human cornea and sclera acquired with a compact custom multiphoton microscope.
Published in Progress in retinal and eye research
Adaptive optics (AO)-enhanced en face retinal imaging, termed here AO ophthalmoscopy (AOO) has reached a level of robustness which fuels its increasing use in research and clinical centers. Here we will review the contribution of clinical AOO to the understanding and monitoring of 1) age-related macular degeneration and 2) vascular diseases. The ma...
The design and performance of an adaptive optics flood illumination ophthalmoscope (AO-FIO) platform, based on eye motion and dynamic aberrations experimental analysis, are described. The system incorporates a custom-built real-time controller, enabling up to 70 Hz loop rate without jitter, and an AO-corrected illumination capable of projecting hig...
The work presented here is dedicated to high angular resolution techniques applied to astronomy and ophthalmology.The first part, corresponding to the PhD thesis and the immediate post-thesis, deals with data processing and design of interferometric systems.The second part of my work focuses on optimizing the various ingredients of an adaptive opti...
Les travaux exposés portent sur les techniques d'imagerie optique à haute résolution et plus particulièrement sur les méthodes, dites d'inversion, de traitement des données associées à ces techniques. Ils se situent donc à la croisée des chemins entre l'imagerie optique et le traitement du signal et des images. Ces travaux sont appliqués à l'astron...
PURPOSE: To characterize developmental defects and the time course of Norrie disease in retinal and hyaloid vasculature during retinal development and to identify underlying molecular angiogenic pathways that may be affected in Norrie disease, exudative vitreoretinopathy, retinopathy of prematurity, and Coats' disease. METHODS: Norrie disease pseud...
