Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight...
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status: published
Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study
PURPOSE: The impact of body mass index (BMI) on outcomes in respiratory failure necessitating extracorporeal membrane oxygenation (ECMO) has been poorly described. We aimed to assess: (i) whether adults with class II obesity or more (BMI ≥ 35 kg/m2) have worse outcomes than lean counterparts, (ii) the form of the relationship between BMI and outcom...
High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice
A high-fat diet can lead to gut microbiota dysbiosis, chronic intestinal inflammation, and metabolic syndrome. Notably, resulting phenotypes, such as glucose and insulin levels, colonic crypt cell proliferation, and macrophage infiltration, exhibit sex differences, and females are less affected. This is, in part, attributed to sex hormones. To inve...
PiT2 deficiency prevents increase of bone marrow adipose tissue during skeletal maturation but not in OVX-induced osteop...
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The common cellular origin between bone marrow adipocytes (BMAds) and osteoblasts contributes to the intimate link between bone marrow adipose tissue (BMAT) and skeletal health. An imbalance between the differentiation ability of BMSCs towards one of the two lineages occurs in conditions like aging or osteoporosis, where bone mass is decreased. Rec...
Validation of a multi-frequency bioelectrical impedance analysis device for the assessment of body composition in older ...
10.1038/s41387-022-00223-1 / NUTRITION & DIABETES / 12 / 1
Maternal acrylamide exposure during pregnancy and fetal growth: A systematic review and dose-response meta-analysis of e...
BACKGROUND: Acrylamide is a food contaminant linked to developmental toxicity in animals and possibly in humans. OBJECTIVES: We performed a systematic review and dose-response meta-analysis of epidemiological studies evaluating the relationship between maternal acrylamide exposure during pregnancy and the risk of being small for gestational age (SG...
Imaging-based body fat depots and new-onset atrial fibrillation in general population: a prospective cohort study
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BACKGROUND: Obesity is a well-established risk factor for atrial fibrillation (AF). Whether body fat depots differentially associate with AF development remains unknown. METHODS: In the prospective population-based Rotterdam Study, body composition was assessed using dual-energy X-ray absorptiometry (DXA) and liver and epicardial fat using computed...
Vitamin D3 Supplementation in Overweight/Obese Pregnant Women: No Effects on the Maternal or Fetal Lipid Profile and Bod...
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Vitamin D deficiency is a common finding in overweight/obese pregnant women and is associated with increased risk for adverse pregnancy outcome. Both maternal vitamin D deficiency and maternal obesity contribute to metabolic derangements in pregnancy. We aimed to assess the effects of vitamin D3 supplementation in pregnancy versus placebo on matern...
Newborn body composition and child cardiovascular risk markers: a prospective multi-ethnic Asian cohort study
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10.1093/ije/dyac154 / INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Investigation of metabolomic biomarkers for childhood executive function and the role of genetic and dietary factors: Th...
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10.1016/j.ebiom.2022.104111 / EBIOMEDICINE / 81
