Li, Mingwei Wei, Lifan Zhou, Wei He, Zhiyan Ran, Shujun Liang, Jingping
Published in
Stem Cell Research & Therapy
BackgroundUpon migrating to the injured sites, bone marrow mesenchymal stem cells (BMSCs) play critical roles in the repair of bone lesion caused by chronic apical periodontitis. Emerging evidences have shown that Enterococcus faecalis is always associated with apical periodontitis, especially refractory apical periodontitis. But the mechanism unde...
Han, Min Chen, Xiao-Cui Sun, Ming-Hui Gai, Min-Tao Yang, Yi-Ning Gao, Xiao-Ming Ma, Xiang Chen, Bang-Dang Ma, Yi-Tong
Published in
Lipids in Health and Disease
BackgroundInflammation and oxidative stress play predominant roles in the initiation and progression of ischaemia/reperfusion (I/R) injury, with nuclear factor kappa B (NF-κB) serving as a crucial mediator. Overexpression of the inhibitor of κB alpha (IκBα) gene is hypothesized to have protective effects against apoptosis and autophagy in cardiomyo...
Tang, Biao Liu, Dan Chen, Lingyu Liu, Yu
Published in
Journal of Inflammation
BackgroundPrimary dysmenorrhea (PD) constitutes a common gynecological disease among young women. The NLRP3 inflammasome may be activated and expressed in PD, but the mechanistic link between NLRP3 inflammasome activation and PD is still unclear.MethodsTo investigate the potential role of NLRP3 inflammasome activation in the pathogenesis of PD, 30 ...
Girouard, Julie Belgorosky, Denise Hamelin-Morrissette, Jovane Boulanger, Valerie D'Orio, Ernesto Ramla, Djamel Perron, Robert Charpentier, Lucie Van Themsche, Céline Eiján, Ana Maria
...
Published in
Biochemical pharmacology
Muscle-invasive bladder cancer (MIBC) is an aggressive form of urothelial bladder carcinoma (UBC) with poorer outcomes compared to the non-muscle invasive form (NMIBC). Higher recurrent rates and rapid progression after relapse in UBC is known to be linked with chronic inflammation. Here, the preclinical murine models of NMIBC (MB49) and MIBC (MB49...
Eo, Hyun Ji Kwon, Hae Yun Da Kim, Som Kang, Yeongyeong Park, Youngki Park, Gwang Hun
Published in
Plant Biotechnology Reports
Hibiscus syriacus (H. syriacus), which belongs to Malvaceae, is a perennial herb widely distributed in East Asia. In this study, we investigated the anti-inflammatory effects and its potential molecular mechanisms of leaves extracted with 70% ethanol of H. syriacus (HS-L) at the mRNA and protein level when RAW264.7 macrophages were stimulated by LP...
Ajayi, Abayomi M Badaki, Victoria B Ariyo, Oluwakemi O Ben-Azu, Benneth Asejeje, Folake O Adedapo, Aduragbenro D A
Published in
Nutrition research (New York, N.Y.)
Chrysophyllum abidum fruit is a seasonal fruit commonly eaten as snacks with abundant health promoting phytochemicals in the fruit peels. The fruit peels have been reported to be rich in anti-inflammatory eleagnine, myricetin rhamnoside, quercetin, linoleic acid and oleic acid. We hypothesized that the anti-inflammatory effect of the peel extract i...
Mahdavi Sharif, Pouya Jabbari, Parnian Razi, Sepideh Keshavarz-Fathi, Mahsa Rezaei, Nima
Published in
Cytokine
TNF-alpha is involved in many physiologic and pathologic cellular pathways, including cellular proliferation, differentiation, and death, regulation of immunologic reactions to different cells and molecules, local and vascular invasion of neoplasms, and destruction of tumor vasculature. It is obvious that because of integrated functions of TNF-alph...
Attia, Hala Fadda, Laila Al-Rasheed, Nouf Al-Rasheed, Nawal Maysarah, Nadia
Published in
Naunyn-Schmiedeberg's archives of pharmacology
The purpose of the present study was to investigate the preventive effect of L-arginine (ARG) and carnosine (CAR) on hypoxia-induced neurotoxicity in rats. The impact on neuro-inflammation, apoptosis, angiogenesis, and the brain levels of monoamines and GABA were investigated. Rats were divided into the following: normal control, hypoxia model indu...
Bhardwaj, Rabia Singh, Brij Pal Sandhu, Nitika Singh, Niharika Kaur, Ravinder Rokana, Namita Singh, Kumar Siddharth Chaudhary, Vishu Panwar, Harsh
Published in
Molecular biology reports
Diabetes and other lifestyle disorders have been recognized as the leading cause of morbidity and mortality globally. Nuclear factor kappa B (NF-κB) is a major factor involved in the early pathobiology of diabetes and studies reveal that hyperglycemic conditions in body leads to NF-κB mediated activation of several cytokines, chemokines and inflamm...
shin, n r a lee, y song, j h yang, s park, i o lim, j jung, t y kim, j c lim, kyungseob lee, y
...
BACKGROUND: Scrophularia buergeriana Miq. (Scrophulariaceae) (SB) has been used as an oriental medicine for the treatment of inflammatory diseases, such as neuritis and pharyngolaryngitis. PURPOSE: We explored the therapeutic effects of S. buergeriana ethanol extract (SBE) on airway inflammation in ovalbumin (OVA)-induced asthmatic mice and lipopol...
