Sun, Yiting Duan, Jianchun Fang, Wenfeng Wang, Zhijie Du, Xinyang Wang, Xin Li, Chengcheng Cai, Shangli Zhao, Jie Li, Sini
...
Published in
BMC Medicine
Background With the revolutionary progress of immune checkpoint inhibitors (ICIs) achieved in non-small cell lung cancers (NSCLC), identifying patients benefiting from ICIs becomes critical and urgent. The associations of genomic alterations in protein tyrosine phosphatase receptor-type (PTPRs) and ICIs responses are unknown. Methods Whole-exome se...
Ma, Cong Wang, Xiaoyan Guo, Jingjing Liu, Ping
Published in
Lipids in Health and Disease
Background Abnormalities in serum lipids and lipoproteins have been documented to link to the risk of cancers in recent years, but its prognostic value for cancer is not known. This study retrospectively evaluated the significance of preoperative serum lipids and lipoproteins for NSCLC’s prognosis. Methods A retrospective review was implemented of ...
Vilinovszki, Oliver Andratschke, Nicolaus Huellner, Martin Curioni-Fontecedro, Alessandra Kroeze, Stephanie G. C.
Published in
Radiation Oncology (London, England)
Background Systemic response to local anticancer treatment is a phenomenon called ‘abscopal effect’. The immune system is thought to play a pivotal role in its occurrence. To date, several cases have been reported, particularly in patients receiving combined local treatment and immune checkpoint inhibitors. In such cases, it is impossible to discri...
Zhao, Shen Zhang, Zhonghan Zhan, Jianhua Zhao, Xin Chen, Xinru Xiao, Liyun Wu, Kui Ma, Yuxiang Li, Mengzhen Yang, Yunpeng
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Published in
BMC Medicine
Background With the identification of new targetable drivers and the recent emergence of novel targeted drugs, using comprehensive genomic profiling in lieu of the routine testing for classic drivers in the clinical care for advanced NSCLC has been increasingly advocated. However, the key assumption justifying this practice, that comprehensive geno...
Celik, Emir Samanci, Nilay Sengul Karadag, Mehmet Demirci, Nebi Serkan Cikman, Duygu Ilke Derin, Sumeyra Bedir, Sahin Degerli, Ezgi Oruc, Kerem Oztas, Nihan Senturk
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Published in
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Erlotinib is an effective treatment option for EGFR-mutant non-small cell lung cancer. It is important to predict patients who will respond better to erlotinib. We designed this study to investigate the effect of renal insufficiency (RI) on erlotinib treatment outcomes. All patients receiving erlotinib were stratified into 3 groups. Group 1 consist...
Wang, Zhiyu Liu, Liang Du, Yuankun Mi, Yuan Wang, Lei
Published in
Cell biology and toxicology
It has been widely reported that long non-coding RNAs (lncRNAs) could affect the varieties of tumor response to radiotherapy. LncRNA HNF1A-AS1 is transcribed from HNF1A gene cluster's antisense strand. This work focused on the mechanism of how HNF1A-AS1 participated in the radiosensitivity of non-small cell lung cancer (NSCLC). The mRNA or protein ...
Zhang, Yao Shen, Ji-Qiao Shao, Lin Chen, Yan Lei, Lei Wang, Jia-Lei
Published in
World Journal of Clinical Cases
BACKGROUND Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been adopted as the standard of care for non-small cell lung cancer (NSCLC) patients harboring EGFR sensitizing mutations. Besides the two common mutations exon 19 deletion and L858R, which together comprise approximately 85% of EGFR mutations in NSCLC, rare E...
Hoppstädter, Jessica Dembek, Anna Höring, Marcus Schymik, Hanna S. Dahlem, Charlotte Sultan, Afnan Wirth, Natalie Al-Fityan, Salma Diesel, Britta Gasparoni, Gilles
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Published in
EBioMedicine
Background Based on reports on elevated cholesterol levels in cancer cells, strategies to lower cholesterol synthesis have been suggested as an antitumour strategy. However, cholesterol depletion has also been shown to induce tumour-promoting actions in tumour-associated macrophages (TAMs). Methods We performed lipidomic and transcriptomic analyses...
Ma, Xiaofen Lee, Chaebin Zhang, Tao Cai, Jinghua Wang, Hui Jiang, Fangchao Wu, Zhanhong Xie, Jin Jiang, Guihua Li, Zibo
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Published in
Journal of Nanobiotechnology
Background Recently, gadolinium-intercalated carbon dots ([email protected]) have demonstrated potential advantages over traditional high-Z nanoparticles (HZNPs) as radiosensitizers due to their high stability, minimal metal leakage, and remarkable efficacy. Results In this work, two [email protected] formulations were fabricated which bore carboxylic acid ([email protected]
Morianos, Ioannis Tsitsopoulou, Aikaterini Potaris, Konstantinos Valakos, Dimitrios Fari, Ourania Vatsellas, Giannis Bostantzoglou, Clementine Photiades, Andreas Gaga, Mina Xanthou, Georgina
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Published in
Journal of Experimental & Clinical Cancer Research : CR
Background Although tumor-infiltrating T cells represent a favorable prognostic marker for cancer patients, the majority of these cells are rendered with an exhausted phenotype. Hence, there is an unmet need to identify factors which can reverse this dysfunctional profile and restore their anti-tumorigenic potential. Activin-A is a pleiotropic cyto...
