NITEGE-Expression in Meniscal Matrix. A New, Immunohistochemical Marker of Meniscal-Tissue Degeneration
Published in Journal of Orthopaedics and Trauma
Background. No marker reflecting the patho-biology of meniscal degeneration (MD) is established so far. NITEGE is a hexapeptide fragments produced when aggrecan is cleaved. Methods. In vitro IL-1 exposition of bovine menisci (n = 4) caused extracellular NITEGE deposits detected by immunofluorescence. A retrospective immunohistochemical analysis of ...
