branda, francesco ceccarelli, giancarlo giovanetti, marta albanese, mattia binetti, erica ciccozzi, massimo scarpa, fabio
The re-emergence of the Nipah virus (NiV) in Kerala, India, following the tragic death of a 14-year-old boy, underscores the persistent threat posed by zoonotic pathogens and highlights the growing global public health challenge. With no vaccine or curative treatment available, and fatality rates as high as 94% in past outbreaks, the Nipah virus is...
Komal, Diksha, Patil, Niraj S Singh, Amandeep
Published in
Infectious disorders drug targets
Mohandas, Sreelekshmy Patil, Dilip Mathapati, Basavaraj Rai, Vishal Shete, Anita Belani, Sujeet Kumar, Abhinendra Sahay, Rima Patil, Deepak Yadav, Pragya D.
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Published in
Frontiers in Microbiology
Introduction India has experienced seven outbreaks of the Nipah virus (NiV) since 2001, primarily occurring in the southern and eastern regions of the country. The southern region has been the main site for these outbreaks. In contrast, the eastern region, which borders Bangladesh, has not reported any outbreaks since 2007. However, Bangladesh cont...
Wang, Limei Lu, Denghui Yang, Maosen Chai, Shiqi Du, Hong Jiang, Hong
Published in
Frontiers of medicine
Nipah virus (NiV) is a zoonotic paramyxovirus that has recently emerged as a crucial public health issue. It can elicit severe encephalitis and respiratory diseases in animals and humans, leading to fatal outcomes, exhibiting a wide range of host species tropism, and directly transmitting from animals to humans or through an intermediate host. Huma...
Dsouza, Norine C, Selvaa Kumar
Published in
Journal of biomolecular structure & dynamics
The infectious Nipah virus (NiV) is categorized into NiV-M (Malaysia) and NiV-B (Bangladesh) groups based on its genome comparison, pathogenicity, and mortality rate. The development of therapeutic molecules has used NiV-M-derived data in multiple studies than NiV-B. In continuation with this, the protein level investigation is also less explored t...
Haas, Griffin D. Kowdle, Shreyas Schmitz, Katharina S. Azarm, Kristopher D. Johnson, Kendra N. Klain, William R. Freiberg, Alexander N. Cox, Robert M. Plemper, Richard K. Lee, Benhur
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Published in
Journal of Virology
Henipaviruses are recognized as significant global health threats due to their high mortality rates and lack of effective vaccines or therapeutics. Due to the requirement for high biocontainment facilities, the scope of research which may be conducted on henipaviruses is limited. To address this challenge, we developed innovative tetracistronic, tr...
Avanzato, Victoria A. Bushmaker, Trenton Oguntuyo, Kasopefoluwa Y. Yinda, Claude Kwe Duyvesteyn, Helen M. E. Stass, Robert Meade-White, Kimberly Rosenke, Rebecca Thomas, Tina van Doremalen, Neeltje
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Published in
Journal of Virology
Nipah virus (NiV) is a highly lethal henipavirus (HNV) that causes severe respiratory and neurologic disease in humans. Currently, there are no licensed vaccines or therapeutics against NiV, highlighting a need to develop countermeasures. The NiV surface displays the receptor binding protein (NiV-G, or RBP) and the fusion protein (NiV-F), which all...
Wolf, Josef D. Plemper, Richard K.
Published in
Journal of Virology
Mononegaviruses comprise major human pathogens such as the Ebola virus, rabies virus, respiratory syncytial virus, measles virus, and Nipah virus (NiV). For replication and transcription, their polymerase complexes must negotiate a protein-encapsidated RNA genome, which requires the highly coordinated continuous formation and resolution of protein-...
moon, seo young flores, rochelle a. yim, min lim, heeji kim, seungyeon lee, seung yun lee, yoo-kyoung kim, jae-ouk park, hyejin bae, seong eun
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Nipah virus (NiV), of the Paramyxoviridae family, causes highly fatal infections in humans and is associated with severe neurological and respiratory diseases. Currently, no commercial vaccine is available for human use. Here, eight structure-based mammalian-expressed recombinant proteins harboring the NiV surface proteins, fusion glycoprotein (F),...
sari, indah permata d. ortiz, christopher llynard yang, lee-wei chen, ming-hsiang perng, ming-der tzong-yuan, wu
Nipah virus (NiV) is known to be a highly pathogenic zoonotic virus, which is included in the World Health Organization Research & Development Blueprint list of priority diseases with up to 70% mortality rate. Due to its high pathogenicity and outbreak potency, a therapeutic countermeasure against NiV is urgently needed. As NiV needs to be handled ...
