McDougall, Annie R. A. Hastie, Roxanne Goldstein, Maya Tuttle, Andrew Ammerdorffer, Anne Gülmezoglu, A. Metin Vogel, Joshua P.
Published in
BMC Pregnancy and Childbirth
Background There are few medicines in clinical use for managing preterm labor or preventing spontaneous preterm birth from occurring. We previously developed two target product profiles (TPPs) for medicines to prevent spontaneous preterm birth and manage preterm labor. The objectives of this study were to 1) analyse the research and development pip...
Seifi, Ali Azari Jafari, Amirhossein Mirmoeeni, Seyyedmohammadsadeq Shah, Muffaqam Azari Jafari, Mohammadjavad Nazari, Shahrzad Asgarzadeh, Shafagh Godoy, Daniel Agustin
Published in
Clinical neurology and neurosurgery
The term "cerebrovascular diseases (CVDs)" refers to a broad category of diseases that affect the brain's blood vessels and cerebral circulation. Controlling acute hypertension (HTN) by antihypertensive drugs such as clevidipine and nicardipine can be a highly efficient method of lowering the incidence of CVDs. This is a systematic review and meta-...
Kerschbaumer, Johannes Freyschlag, Christian Franz Petr, Ondra Adage, Tiziana Breitenbach J, Joerg Wessels, Lars Wolf, Stefan Hecht, Nils Gempt, Jens Wostrack, Maria
...
Published in
Brain & spine
Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality. Post-hemorrhagic vasospasm with neurological deterioration is a major concern in this context. NicaPlant®, a modified release formulation of the calcium channel blocker nicardipine, has shown vasodilator efficacy preclinically and a similar formulation known ...
Saldana, Sara Breslin, James 2nd Hanify, Jennifer Heierman, Theodore Larizadeh, Kristina Sanchez, Michael Phipps, William
Published in
Neurocritical care
Intracranial hemorrhage is associated with high mortality and morbidity. Lowering systolic blood pressure (SBP) with an intravenous antihypertensive, such as nicardipine or clevidipine, may reduce the risk of hematoma expansion and rebleeding. Previous studies comparing nicardipine and clevidipine in patients with stroke found no significant differ...
Toyoda, Kazunori Koga, Masatoshi
Published in
Hypertension research : official journal of the Japanese Society of Hypertension
The impact of acute therapy for intracerebral hemorrhage (ICH) lags far behind that for acute ischemic stroke. Intensive blood pressure lowering is a promising therapeutic strategy for acute ICH, especially for East Asian patients whose etiological mechanism is more commonly hypertension than that of patients in the Western population. A multicente...
Horikoshi, Yuko Katsuda, Shin-Ichiro Fujikura, Yuko Hazama, Akihiro Shimura, Hiroki Shimizu, Tsuyoshi Shirai, Kohji
Published in
Journal of atherosclerosis and thrombosis
The cardio-ankle vascular index (CAVI) consists of intrinsic and functional arterial stiffness mainly regulated by vasoactive compounds. A new stiffness index of the aorta (aBeta) and iliac-femoral arteries (ifBeta) was determined by applying the CAVI theory to the whole aorta and iliac-femoral arteries. We investigated the changes in aBeta and ifB...
Akbik, Feras Waddel, Hannah Jaja, Blessing N R Macdonald, R Loch Moore, Renee Samuels, Owen B Sadan, Ofer
Published in
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
A paucity of treatments to prevent delayed cerebral ischemia (DCI) has stymied recovery after aneurysmal subarachnoid hemorrhage (aSAH). Nicardipine has long been recognized as a potent cerebrovascular vasodilator with a history off-label use to prevent vasospasm and DCI. Multiple centers have developed nicardipine prolonged release implants (NPRI)...
Lee, Yong Ho Hong, Ji Hee Shin, Hye Kyung
Published in
Anesthesia and Pain Medicine
Background Gasserian ganglion radiofrequency thermoablation is a good treatment option for the management of pain in trigeminal neuralgia. We report a case in which the patient of trigeminal neuralgia combined with anterior cerebral artery aneurysm was treated successfully by gasserian ganglion thermoablation without any complication. Case An 85-ye...
Yokoya, Shigeomi Hino, Akihiko Goto, Yukihiro Oka, Hideki
Published in
Surgical Neurology International
Background: Some patients come to the hospital presenting with ischemic neurological deficits due to postsubarachnoid hemorrhage (SAH) cerebral vasospasm. In such a situation, neurosurgeons tend to avoid direct clipping, since mechanical irritation to the vessels could worsen the vasospasm and exacerbate ischemic symptoms. The optimal timing of dir...
Qi, Haifeng Qin, Jiali Ren, Li Li, Lan Lan, Lan Yan, Yunsheng Gan, Shengwen Zhang, Yaozong
Published in
Pregnancy hypertension
To investigate the efficacy of low-dose intravenous nicardipine for emergent management of severe postpartum hypertension in maternal intensive care units (ICUs). The initial dosage of nicardipine was dependent upon patient systolic blood pressure (SBP). Patients with an SBP of 160-179 mmHg received an initial dosage of 2 mg/h, and 4 mg/h was admin...
