Abraham, Peter Neel, Ian Bishay, Steven Sewell, Daniel D
IntroductionNeuropsychiatric symptoms occur in 30% to 40% of patients living with systemic lupus erythematosus (SLE). Brain imaging may play a pivotal role in determining the etiology as it did for the case presented here.MethodsA new case of central nervous system (CNS) SLE is presented along with an analysis of 33 comparable cases from the scient...
Dong, Jie Li, Aqian Chen, Chuansheng Qu, Jing Jiang, Nan Sun, Yue Hu, Liyuan Mei, Leilei
How native and non-native languages are represented in the brain is one of the most important questions in neurolinguistics. Much research has found that the similarity in neural activity of native and non-native languages are influenced by factors such as age of acquisition, language proficiency, and language exposure in the non-native language. N...
Fleming, Neal W Singh, Amrik Lee, Leonard Applegate, Richard L
BackgroundPerioperative pulse oximetry hemoglobin saturation (Spo2) measurement is associated with fewer desaturation and hypoxia episodes. However, the sigmoidal nature of oxygen-hemoglobin dissociation limits the accuracy of estimation of the partial pressure of oxygen (Pao2) >80 mm Hg and correspondingly limits the ability to identify when Pao2 ...
Escartin, Carole Galea, Elena Lakatos, András O'Callaghan, James P Petzold, Gabor C Serrano-Pozo, Alberto Steinhäuser, Christian Volterra, Andrea Carmignoto, Giorgio Agarwal, Amit
...
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is...
Aladesuyi Arogundade, Olubankole Nguyen, Sandra Leung, Ringo Wainio, Danielle Rodriguez, Maria Ravits, John
Nucleolar stress has been implicated in the pathology and disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) from repeat expansions of GGGGCC in C9orf72 (C9-ALS/FTLD) but not in sporadic ALS (SALS). Previously we reported that antisense RNA transcripts are unique in C9-ALS because of their nucle...
Copping, NA Silverman, JL
BackgroundAngelman Syndrome (AS) is a rare genetic disorder characterized by impaired communication, motor and balance deficits, intellectual disabilities, recurring seizures and abnormal sleep patterns. The genetic cause of AS is neuronal-specific loss of expression of UBE3A (ubiquitin-protein ligase E6-AP), an imprinted gene. Seizure and sleep di...
Hellmuth, Joanna Barnett, T Allen Asken, Breton M Kelly, J Daniel Torres, Leonel Stephens, Melanie L Greenhouse, Bryan Martin, Jeffrey N Chow, Felicia C Deeks, Steven G
...
As cases of coronavirus disease 2019 (COVID-19) mount worldwide, attention is needed on potential long-term neurologic impacts for the majority of patients who experience mild to moderate illness managed as outpatients. To date, there has not been discussion of persistent neurocognitive deficits in patients with milder COVID-19. We present two case...
Lesman-Segev, Orit H La Joie, Renaud Iaccarino, Leonardo Lobach, Iryna Rosen, Howard J Seo, Sang Won Janabi, Mustafa Baker, Suzanne L Edwards, Lauren Pham, Julie
...
ObjectiveThe purpose of this study was to compare the diagnostic accuracy of antemortem 11 C-Pittsburgh compound B (PIB) and 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) versus autopsy diagnosis in a heterogenous sample of patients.MethodsOne hundred one participants underwent PIB and FDG PET during life and neuropathological as...
Mooney, Lindsey N Johnson, Elliott G Prabhakar, Janani Ghetti, Simona
Nonhuman research has implicated developmental processes within the hippocampus in the emergence and early development of episodic memory, but research in humans has been constrained by the difficulty of examining hippocampal function during early development. In the present study, we assessed 48 2-year-olds with a novel paradigm in which participa...
Mariano, ER El-Boghdadly, K Ilfeld, BM