Cisler, Josh M Herringa, Ryan J
Published in
Biological psychiatry
Posttraumatic stress disorder (PTSD) in adolescents is common and debilitating. In contrast to adult PTSD, relatively little is known about the neurobiology of adolescent PTSD, nor about how current treatments may alter adolescent neurodevelopment to allow recovery from PTSD. Improving our understanding of biological mechanisms of adolescent PTSD, ...
Shafik, Andrew M. Zhang, Feiran Guo, Zhenxing Dai, Qing Pajdzik, Kinga Li, Yangping Kang, Yunhee Yao, Bing Wu, Hao He, Chuan
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Published in
Genome Biology
BackgroundN6-methyladenosine (m6A) modification is known to impact many aspects of RNA metabolism, including mRNA stability and translation, and is highly prevalent in the brain.ResultsWe show that m6A modification displays temporal and spatial dynamics during neurodevelopment and aging. Genes that are temporally differentially methylated are more ...
Barnes, Fiona Graham, Lynda Loganathan, Prakash Nair, Vrinda
Published in
Indian journal of pediatrics
To assess the value of general movements (GMs) in predicting the neurodevelopmental outcome using Bayley Scale of Infant Development III (BSID-III) at two years of age in very low birth weight (VLBW) infants. This is a five-year observational study (January 2012-June 2017). Two hundred twenty-seven VLBW infants were assessed in the neurodevelopment...
Chen, Zhong Maqbool, Javeria Sajid, Faiqa Hussain, Ghulam Sun, Tao
Published in
Microbial pathogenesis
Human gut microbiota consists of various microorganisms whose numbers are similar to those of human cells. Human gut microbes and the brain form bidirectional communications through the brain-gut-axis, and play a central role in normal physiological processes and in pathogenesis of many human diseases. Accumulating evidence has demonstrated the cru...
Yiu, Glenn Thomasy, Sara M Casanova, M Isabel Rusakevich, Alexander Keesler, Rebekah I Watanabe, Jennifer Usachenko, Jodie Singapuri, Anil Ball, Erin E Bliss-Moreau, Eliza
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Published in
JCI insight
Congenital Zika syndrome (CZS) is associated with microcephaly and various neurological, musculoskeletal, and ocular abnormalities, but the long-term pathogenesis and postnatal progression of ocular defects in infants are not well characterized. Rhesus macaques are superior to rodents as models of CZS because they are natural hosts of the virus and...
Berg, Elizabeth L. Ching, Tianna M. Bruun, Donald A. Rivera, Josef K. Careaga, Milo Ellegood, Jacob Lerch, Jason P. Wöhr, Markus Lein, Pamela J. Silverman, Jill L.
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Published in
Journal of Neurodevelopmental Disorders
BackgroundNeurodevelopmental disorders (NDDs), including intellectual disability, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), are pervasive, lifelong disorders for which pharmacological interventions are not readily available. Substantial increases in the prevalence of NDDs over a relatively short period may...
White, Marina Feucht, Ute D. Duffley, Eleanor Molokoane, Felicia Durandt, Chrisna Cassol, Edana Rossouw, Theresa Connor, Kristin L.
Published in
Pilot and Feasibility Studies
BackgroundAs mother-to-child transmission of HIV decreases, and the population of infants who are born HIV-exposed, but uninfected (HEU) continues to rise, there is a growing need to understand the development and health outcomes of infants who are HEU to ensure that they have the healthiest start to life.MethodsIn a prospective cohort pilot study ...
Levitan, Robert D. Zhang, Cindy X. W. Knight, Julia A. Hung, Rayjean Lye, Jennifer Murphy, Kellie Atkinson, Leslie Bocking, Alan Lye, Stephen Matthews, Stephen G.
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Published in
Current Psychiatry Reports
Purpose of ReviewTo consider various precision medicine approaches to further elucidate the relationship between inflammation and depression and to illustrate how a neurodevelopmental perspective can help in this regard.Recent FindingsInflammation associates most strongly with phenotypes of depression that reflect illness behavior and/or metabolic ...
Szumlinski, Karen K Thompson, Daria L Renton, Rachel M Ary, Alexis W Lominac, Kevin D
Published in
Brain research
For over 50 years, the sympathomimetic phenylpropanolamine (PPA; ±-norephedrine) was a primary active ingredient in over-the-counter nasal decongestants for both children and adults and continues to be prevalent in the vast majority of countries today. Previously, we reported that juvenile PPA exposure alters the developmental trajectory of catecho...
Schmitt, Cassandra Peterson, Eric Willis, Audrey Kumar, Naveen McManus, Michelle Subbiah, Seenivasan Crago, Jordan
Published in
Toxicology and applied pharmacology
The organophosphate chlorpyrifos, and its active metabolite chlorpyrifos-oxon (CPO), have been attributed to a number of neurodevelopmental disorders. It is unclear if the adverse effects associated with developmental exposure to the active CPO persist into adulthood and future generations. The goal of this study was to investigate whether CPO-asso...