Vetel, Steven Vercouillie, Johnny Buron, Frédéric Vergote, Jackie Tauber, Clovis Busson, Julie Chicheri, Gabrielle Routier, Sylvain Sérrière, Sophie Chalon, Sylvie
...
Published in
Molecular imaging and biology
The nicotinic acetylcholine alpha-7 receptors (α7R) are involved in a number of neuropsychiatric and neurodegenerative brain disorders such as Parkinson's disease (PD). However, their specific pathophysiologic roles are still unclear. In this context, we studied the evolution of these receptors in vivo by positron emission tomography (PET) imaging ...
Quitterer, Ursula AbdAlla, Said
Published in
Pharmacological research
With ageing of the global society, the frequency of ageing-related neurodegenerative diseases such as Alzheimer`s disease (AD) is on the rise worldwide. Currently, there is no cure for AD, and the four drugs approved for AD only have very small effects on AD symptoms. Consequently, there are enormous efforts worldwide to identify new targets for tr...
Zhang, Xinwen Hu, Di Shang, Yutong Qi, Xin
Published in
Biochimica et biophysica acta. Molecular basis of disease
Current application of human induced pluripotent stem cells (hiPSCs) technology in patient-specific models of neurodegenerative disorders recapitulate some of key phenotypes of diseases, representing disease-specific cellular modeling and providing a unique platform for therapeutics development. We review recent efforts toward advancing hiPSCs-deri...
Sahab-Negah, Sajad Hajali, Vahid Moradi, Hamid Reza Gorji, Ali
Published in
Cellular and molecular neurobiology
Alzheimer's disease (AD) is described as cognitive and memory impairments with a sex-related epidemiological profile, affecting two times more women than men. There is emerging evidence that alternations in the hippocampal neurogenesis occur at the early stage of AD. Therapies that may effectively slow, stop, or regenerate the dying neurons in AD a...
Hijaz, Baraa A. Volpicelli-Daley, Laura A.
Published in
Molecular Neurodegeneration
The two main pathological hallmarks of Parkinson’s disease are loss of dopamine neurons in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of α-synuclein, called Lewy pathology. Levodopa to enhance dopaminergic transmission remains one of the most effective treatment for alleviating the motor symptoms of Parkins...
Varga, Júlia Dér, Nikolett Petra Zsindely, Nóra Bodai, László
Published in
Nutritional neuroscience
Objectives: Green tea infusion contains a complex mixture of polyphenolic compounds that were shown to provide health benefits. It was previously demonstrated that (-)-epigallocatechin-3-gallate, one of the major polyphenols present in green tea, has a suppressing effect on various aspects of pathogenesis in models of Huntington's disease (HD), an ...
Yan, Xu Uronen, Riikka-Liisa Huttunen, Henri J
Published in
Seminars in cell & developmental biology
α-synuclein and Tau are proteins prone to pathological misfolding and aggregation that are normally found in the presynaptic and axonal compartments of neurons. Misfolding initiates a homo-oligomerization and aggregation cascade culminating in cerebral accumulation of aggregated α-synuclein and Tau in insoluble protein inclusions in multiple neurod...
Obrocki, Pawel Khatun, Ayesha Ness, Deborah Senkevich, Konstantin Hanrieder, Jörg Capraro, Federica Mattsson, Niklas Andreasson, Ulf Portelius, Erik Ashton, Nicholas J.
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Published in
Alzheimer's Research & Therapy
Until relatively recently, a diagnosis of probable Alzheimer’s disease (AD) and other neurodegenerative disorders was principally based on clinical presentation, with post-mortem examination remaining a gold standard for disease confirmation. This is in sharp contrast to other areas of medicine, where fluid biomarkers, such as troponin levels in my...
Konen, Lyndsey M. Wright, Amanda L. Royle, Gordon A. Morris, Gary P. Lau, Benjamin K. Seow, Patrick W. Zinn, Raphael Milham, Luke T. Vaughan, Christopher W. Vissel, Bryce
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Published in
Molecular Brain
Calcium (Ca2+)-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca2+-permeable if they lack the GluA2 subunit or if GluA2 is unedited at a single nucleic acid, known as the Q/R site. In this study, we examined mice engineered with a point mutation in the int...
Pearce, Alan J. Sy, Joanne Lee, Maggie Harding, Antony Mobbs, Rowena Batchelor, Jennifer Suter, Catherine M. Buckland, Michael E.
Published in
Acta Neuropathologica Communications
