Thakur, Nanamika Pandey, Rajeev Kumar Mannan, Rashim Pruthi, Archna Mehrotra, Sanjana
Published in
BMC Ophthalmology
PurposeTransforming growth factor beta (TGFB) is an important candidate gene implicated in glaucoma pathogenesis because it affects retinal ganglionic cell survival. The present study assessed the genetic association of -509C > T variant in the TGFB promoter region with primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) in...
Caglar, Ozgur Arslan, Remzi Firinci, Binali Aydin, Muhammed Enes Karadeniz, Erdem Nalci, Kemal Alp Salman, Ahmet Bedii Aydin, Mehmet Dumlu
Published in
Annals of Pediatric Surgery
BackgroundCircumcision is a surgical removal process of the preputium. Surgical excision and electric current cause neurodegeneration in the excised tissue-related neural network. This study investigates if circumcision and current surgical methods would cause histopathological changes in the penile tissue innervating pudendal nerve dorsal root gan...
Kwon, Diana
Published in
Nature
A class of drugs that silence the effects of faulty genes could help tackle brain diseases — but a halted clinical trial has brought the field up short.
Ayubcha, Cyrus Moghbel, Mateen Borja, Austin J Newberg, Andrew Werner, Thomas J Alavi, Abass Revheim, Mona-Elisabeth
Published in
PET clinics
Tau proteins play a significant role in a variety of degenerative neurologic conditions. Postmortem neuropathology studies of victims of repeat and severe head trauma have defined a unique spatial expression of neurologic tauopathies in these individuals, known as chronic traumatic encephalopathy. Established and newly developed radiotracers are no...
Allegri, R F Chrem Mendez, P Russo, M J Cohen, G Calandri, I Campos, J Nahas, F Surace, E Vazquez, S Sevlever, G
...
Published in
Neurologia (Barcelona, Spain)
This study aimed to investigate the role and prognosis of Alzheimer disease biomarkers in patients with mild cognitive impairment (MCI) at a memory clinic in Latin America. We studied 89 patients with MCI, 43 with Alzheimer-type dementia, and 18 healthy controls (matched for age, sex, and educational level) at our memory clinic (Instituto FLENI) in...
Frew, Jonathan Nygaard, Haakon Berge
Published in
Acta Neuropathologica Communications
Frontotemporal lobar degeneration (FTLD) causes a spectrum of clinical presentations of frontotemporal dementia (FTD), including progressive changes in behavior, personality, executive function, and language. Up to 20% of familial FTLD cases are caused by progranulin (GRN) haploinsufficiency (FTD-GRN), with one of the most common causal variant bei...
Ng, Kok Pin Chiew, Hui Rosa-Neto, Pedro Kandiah, Nagaendran Ismail, Zahinoor Gauthier, Serge
Published in
Translational Neurodegeneration
The development of in vivo biomarkers of Alzheimer’s disease (AD) has advanced the diagnosis of AD from a clinical syndrome to a biological construct. The preclinical stage of AD continuum is defined by the identification of AD biomarkers crossing the pathological threshold in cognitively unimpaired individuals. While neuropsychiatric symptoms (NPS...
Tissot, Cécile L. Benedet, Andréa Therriault, Joseph Pascoal, Tharick A. Lussier, Firoza Z. Saha-Chaudhuri, Paramita Chamoun, Mira Savard, Melissa Mathotaarachchi, Sulantha S. Bezgin, Gleb
...
Published in
Alzheimer's Research & Therapy
BackgroundTo investigate the association of plasma pTau181, assessed with a new immunoassay, with neurodegeneration of white matter and gray matter cross-sectionally and longitudinally, in aging and Alzheimer’s disease.MethodsObservational data was obtained from the Alzheimer’s Disease Neuroimaging Initiative, in which participants underwent plasma...
Xia, Fan Ha, Yonju Shi, Shuizhen Li, Yi Li, Shengguo Luisi, Jonathan Kayed, Rakez Motamedi, Massoud Liu, Hua Zhang, Wenbo
...
Published in
Acta Neuropathologica Communications
The retina, as the only visually accessible tissue in the central nervous system, has attracted significant attention for evaluating it as a biomarker for neurodegenerative diseases. Yet, most of studies focus on characterizing the loss of retinal ganglion cells (RGCs) and degeneration of their axons. There is no integrated analysis addressing temp...
Kubota, Shun Doi, Hiroshi Koyano, Shigeru Tanaka, Kenichi Komiya, Hiroyasu Katsumoto, Atsuko Ikeda, Shingo Hashiguchi, Shunta Nakamura, Haruko Fukai, Ryoko
...
Published in
Molecular Brain
Intracellular aggregates are a common pathological hallmark of neurodegenerative diseases such as polyglutamine (polyQ) diseases, amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and multiple system atrophy (MSA). Aggregates are mainly formed by aberrant disease-specific proteins and are accompanied by accumulation of other aggregate-...
