Galli, Nicole Pettine, Loredana Panigada, Mauro Daprai, Laura Suriano, Grazia Grancini, Anna Barcellini, Wilma Fattizzo, Bruno
Published in
Frontiers in Immunology
Paroxysmal nocturnal haemoglobinuria (PNH) is a rare acquired haematopoietic stem cell disease characterized by complement-mediated intravascular hemolysis, thrombosis, and bone marrow failure. Eculizumab and ravulizumab are anti-C5 monoclonal antibodies that reduce hemolysis, anaemia and thrombotic risk, but are associated with increased risk of i...
Rafi, Md Oliullah Al-Khafaji, Khattab Tok, Tugba Taskin Rahman, Md Shahedur
Published in
Journal of biomolecular structure & dynamics
In silico studies are attracting considerable interest due to their ability to understand protein-ligand interactions at the atomic level. The main principal tools of this in silico analyses are molecular docking and molecular dynamic (MD) simulation. This paper examines how can natural compounds that are derived from Salviae miltiorrhizae to block...
rivero-calle;, irene
We conducted an age-based risk analysis of meningococcal disease in Spain to provide prospects on a rational vaccine schedule in pediatrics. We used the National Hospital Registry to estimate meningococcal hospitalization rate. Population census for each year was used as the denominator in computing the hospitalization rate. We computed the odds ra...
Arunachalam, Arun B. Vile, Stacey Rosas, Angel
Published in
Frontiers in Immunology
The identification of an appropriate animal model for use in the development of meningococcal vaccines has been a challenge as humans are the only natural host for Neisseria meningitidis. Small animal models have been developed and are widely used to study the efficacy or immunogenicity of vaccine formulations generated against various diseases. He...
Fahimzad, A. Khatmi, M. Shiva, F. Mortazavi, S.E. Shirvani, F. Gorji, F.A.
Published in
New Microbes and New Infections
Meningitis and meningococcal septicemia are potentially life-threatening illnesses; young people in educational institutions have been repeatedly exposed to outbreaks of meningococcal infections. Since invasive meningococcal disease is preceded by pharyngeal carriage of Neisseria meningitidis , ascertaining the prevalence of meningococcal carriage ...
Potts, Caelin C Retchless, Adam C McNamara, Lucy A Marasini, Daya Reese, Natashia Swint, Stephanie Hu, Fang Sharma, Shalabh Blain, Amy E Lonsway, David
...
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Penicillin and ciprofloxacin are important for invasive meningococcal disease (IMD) management and prevention. IMD cases caused by penicillin- and ciprofloxacin-resistant Neisseria meningitidis containing a ROB-1 β-lactamase gene (blaROB-1) and a mutated DNA gyrase gene (gyrA) have been recently reported in the United States. We examined 2097 menin...
Cohen, Robert Ashman, Marion Taha, Muhamed-Kheir Varon, Emmanuelle Angoulvant, François Levy, Corinne Rybak, Alexis Ouldali, Naim Guiso, Nicole Grimprel, Emmanuel
...
Published in
Infectious diseases now
Since the beginning of the COVID-19 pandemic, reduced incidence of many viral and bacterial infections has been reported in children: bronchiolitis, varicella, measles, pertussis, pneumococcal and meningococcal invasive diseases. The purpose of this opinion paper is to discuss various situations that could lead to larger epidemics when the non-phar...
Alasmari, Abrar Houghton, Joanna Greenwood, Brian Heymann, David Edwards, Phil Larson, Heidi Assiri, Abdullah Ben-Rached, Fathia Pain, Arnab Behrens, Ron
...
Published in
Tropical medicine & international health : TM & IH
The Saudi government requires that all pilgrims receive a quadrivalent meningococcal vaccine at least 10 days before the Hajj. We conducted a study to determine the uptake of meningococcal vaccine and antibiotic use. We also investigated risk factors of meningococcal carriage and carriage of Neisseria meningitidis pathogenic serogroups A, C, W and ...
Fazio, Cecilia Biolchi, Alessia Neri, Arianna Tomei, Sara Vacca, Paola Ambrosio, Luigina Palmieri, Annapina Mori, Elena La Gaetana, Rita Pizza, Mariagrazia
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Published in
Human Vaccines & Immunotherapeutics
The four-component meningococcal serogroup B vaccine (4CMenB) contains antigens present in the majority of meningococci causing invasive meningococcal disease (IMD) and may potentially offer protection against strains belonging to non-B serogroups. This study aimed to evaluate the ability of 4CMenB-induced antibodies to kill, in a human serum bacte...
Hegde, Shruti Nikolaeva, Mariia Johnstone, Michael
Published in
IDCases
Infective endocarditis caused by Neisseria meningitidis (NM) is a very rare manifestation of invasive meningococcal disease with only a few cases described in the literature. We report a case of a native mitral valve endocarditis caused by NM in a 61-year-old female without meningitis. Our case highlights the importance of considering NM as one of ...