Phillips, Laura T Witney, Adam A Furegato, Martina Laing, Ken G Zhou, Liqing Sadiq, S Tariq
Published in
The Journal of infectious diseases
Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a global health challenge. Limitations to AMR surveillance reporting, alongside reduction in culture-based susceptibility testing, has resulted in a need for rapid diagnostics and strain detection. We investigated Nanopore sequencing time, and depth, to accurately identify closely related N...
Ma, Angela Ferrato, Christina Martin, Irene Smyczek, Petra Gratrix, Jennifer Dingle, Tanis C.
Published in
Journal of Clinical Microbiology
Agar dilution is the gold standard method for phenotypic antimicrobial susceptibility testing (AST) for Neisseria gonorrhoeae. However, this method is laborious and requires expertise, so laboratories that perform N. gonorrhoeae AST may choose alternative methods such as disk diffusion and gradient diffusion. In this study, we retrospectively compa...
Mensah, Eric Fourie, P. Bernard Peters, Remco P. H.
Published in
Antimicrobial Agents and Chemotherapy
Therapeutic options for Neisseria gonorrhoeae are limited due to emerging global resistance. New agents and treatment options to treat patients with susceptible and multi-extensively drug-resistant N. gonorrhoeae is a high priority. This study used an in vitro approach to explore the antimicrobial potential, as well as synergistic effects of Medici...
Abu-Hilal, Lila H Njoum, Yumna Jabbarin, Farah M Barghouthi, Duha I Hamamdah, Abdullah Bourini, Mohammad Mtour, Sameer
Published in
Annals of medicine and surgery (2012)
Disseminated gonococcal infection (DGI) is an infrequent but serious complication of gonorrhea that can exhibit atypical symptoms. While rare, it can lead to infective endocarditis (IE), a condition that affects the heart valves and can result in severe and potentially life-threatening outcomes. We present a case of Neisseria gonorrhoeae-caused IE ...
John, Constance M. Phillips, Nancy J. Cardenas, Amaris J. Criss, Alison K. Jarvis, Gary A.
Published in
Frontiers in Microbiology
The alarming rise of antibiotic resistance and the emergence of new vaccine technologies have increased the focus on vaccination to control gonorrhea. Neisseria gonorrhoeae strains FA1090 and MS11 have been used in challenge studies in human males. We used negative-ion MALDI-TOF MS to profile intact lipooligosaccharide (LOS) from strains MS11mkA, M...
Dijokaite-Guraliuc, Aiste Humbert, Maria Victoria Skipp, Paul Cleary, David W. Heckels, John E. Christodoulides, Myron
Published in
Frontiers in Bacteriology
Background Neisseria gonorrhoeae (gonococcus) is the causative agent of the sexually transmitted disease gonorrhea, for which no vaccines exist. Efforts are being made to identify potential vaccine protein antigens, and in this study, an immunoproteomics approach was used to identify protein signatures in gonococci that were recognized by sera from...
Perry, Caroline R Scangarella-Oman, Nicole E Millns, Helen Flight, William Gatsi, Sally Jakielaszek, Charles Janmohamed, Salim Lewis, David A
Published in
Infectious diseases and therapy
Gonorrhea, caused by Neisseria gonorrhoeae (NG), is the second most common bacterial sexually transmitted infection (STI). Rates of antimicrobial resistance to standard care are increasing worldwide, with many antibiotic classes now ineffective against NG. Gepotidacin is a first-in-class, bactericidal, triazaacenaphthylene antibiotic that inhibits ...
Kenyon, Chris Gestels, Zina Vanbaelen, Thibaut Abdellati, Said Van Den Bossche, Dorien De Baetselier, Irith Xavier, Basil Britto Manoharan-Basil, Sheeba Santhini
Published in
Frontiers in Microbiology
Background Four randomized controlled trials have now established that doxycycline post exposure (sex) prophylaxis (PEP) can reduce the incidence of chlamydia and syphilis in men who have sex with men. These studies have concluded that the risk of selecting for antimicrobial resistance is low. We evaluated this risk in vitro and in vivo using a Gal...
Dewan, Harisha
Published in
Biomimetics (Basel, Switzerland)
Additive manufacturing (three-dimensional (3D) printing) has become a leading manufacturing technique in dentistry due to its various advantages. However, its potential applications for dental ceramics are still being explored. Zirconia, among ceramics, has increasing popularity and applications in dentistry mostly due to its excellent properties. ...
Stazzoni, Samuele Troisi, Marco Abbiento, Valentina Sala, Claudia Andreano, Emanuele Rappuoli, Rino
Published in
Frontiers in Microbiology
Neisseria gonorrhoeae (gonococcus) is an obligate human pathogen and the etiological agent of the sexually transmitted disease gonorrhea. The rapid rise in gonococcal resistance to all currently available antimicrobials has become a significant public health burden and the need to develop novel therapeutic and prophylactic tools is now a global pri...
